ALEXIS Biochemicals: Monoclonal Antibody to D4-GDI (cleavage-specific) (97A1015)

ALX-804-264

Revised 19-Sep-05

Monoclonal Antibody to D4-GDI (cleavage-specific) (97A1015)
SYNONYMS	anti-Rho-GDI2 MAb (cleavage-specific) (97A1015)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Caspases Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-264-C100		100 µg	319.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse
CLONE:	97A1015
ISOTYPE:	Mouse IgG2b
CONCENTRATION:	0.5mg/ml
PURITY DETAIL:	Protein G-affinity purified.
FORMULATION:	Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:	Synthetic peptide corresponding to the region of Fas-induced cleavage site of human D4-GDI (Rho-GDI2).
SPECIFICITY:	Recognizes human and mouse D4-GDI. Detects a band of ~23kDa by Western blot.
APPLICATION:	Flow Cytometry (0.5-1µg/10⁶ cells; intracellular staining) Immunohistochemistry (2µg/ml) Immunoprecipitation (1-2µg/ml) Western Blot (2µg/ml)
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for 6 months when stored at +4°C.

Product Specific Literature References

The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change: H. Yamaguchi & H.G. Wang; Oncogene 20, 7779 (2001) Abstract
Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine): S. Sato, et al.; Oncogene 21, 1727 (2002) Abstract
RhoGDI2 is an invasion and metastasis suppressor gene in human cancer: J.J. Gildea, et al.; Cancer Res. 62, 6418 (2002) Abstract
Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax: S.M. Cuddeback, et al.; J. Biol. Chem. 276, 20559 (2001) Abstract; Full Text

General Literature References

Cleavage and nuclear translocation of the caspase 3 substrate Rho GDP-dissociation inhibitor, D4-GDI, during apoptosis: R.J. Krieser & A. Eastman; Cell Death Differ. 6, 412 (1999) Abstract
Rho guanine dissociation inhibitors: pivotal molecules in cellular signalling: B. Olofsson; Cell. Signal. 11, 545 (1999), (Review) Abstract
GDP dissociation inhibitor D4-GDI (Rho-GDI 2), but not the homologous rho-GDI 1, is cleaved by caspase-3 during drug-induced apoptosis: F. Essmann, et al.; Biochem. J. 346 Pt 3, 777 (2000) Abstract; Full Text

Further Categories Containing This Product:

Monoclonal Antibodies

another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.