ALEXIS Biochemicals: Monoclonal Antibody to FLIP (human) (NF6)

ALX-804-428

Revised 21-Aug-08

Monoclonal Antibody to FLIP (human) (NF6)
SYNONYMS	anti-CASPER (human) MAb (NF6) anti-CLARP (human) MAb (NF6) anti-I-FLICE (human) MAb (NF6) anti-Usurpin (human) MAb (NF6)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	FLIP

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-428-C050		50 µg	255.00 USD
ALX-804-428-C100		100 µg	367.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	NF6
ISOTYPE:	Mouse IgG1
CONCENTRATION:	0.5mg/ml
PURITY:	≥95% (SDS-PAGE)
FORMULATION:	Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:	Recombinant human FLIP (aa 1-194).
SPECIFICITY:	Recognizes short (FLIP_S) and long (FLIP_L) splice variants of human FLIP.
APPLICATION:	Western Blot: For superior sensitivity and minimal background we recommend using the secondary PAb to Mouse IgG1 (HRP) (Prod. No. ALX-211-203).
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.
POSITIVE CONTROL:	For Positive Control in Western blot see Prod. No. ALX-840-601.

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Product Specific Literature References

The role of c-FLIP in modulation of CD95-induced apoptosis: S. Scaffidi, et al.; J. Biol. Chem. 274, 1541 (1999) Abstract; Full Text
Enhancement of Apo2L/TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-induced apoptosis in non-small cell lung cancer cell lines by chemotherapeutic agents without correlation to the expression level of cellular protease : S. Frese, et al.; J. Thorac. Cardiovasc. Surg. 123, 168 (2002) Abstract
An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis: Y. Kim, et al.; J. Biol. Chem. 277, 22320 (2002) Abstract; Full Text
Proteasome inhibition results in TRAIL sensitization of primary keratinocytes by removing the resistance-mediating block of effector caspase maturation: M. Leverkus, et al.; Mol. Cell. Biol. 23, 777 (2003) Abstract; Full Text
Suramin inhibits death receptor-induced apoptosis in vitro and fulminant apoptotic liver damage in mice: S.T. Eichhorst, et al.; Nature Med. 10, 602 (2004) Abstract
T.M. Ganten, et al.; Cell Death Differ. 11 Suppl 1, S86 (2004) Abstract
Cellular FLIP (long isoform) overexpression in T cells drives Th2 effector responses and promotes immunoregulation in experimental autoimmune encephalomyelitis: V. Tseveleki, et al.; J. Immunol. 173, 6619 (2004) Abstract; Full Text
cFLIPL inhibits tumor necrosis factor-related apoptosis-inducing ligand-mediated NF-kappaB activation at the death-inducing signaling complex in human keratinocytes: T. Wachter, et al.; J. Biol. Chem. 279, 52824 (2004) Abstract; Full Text
Elevated NF-kappaB responses and FLIP levels in leukemic but not normal lymphocytes: reduction by salicylate allows TNF-induced apoptosis: C. Rae, et al.; PNAS 104, 12790 (2007) Abstract
A Protective Role for the Human SMG-1 Kinase against Tumor Necrosis Factor-α-induced Apoptosis: V. Oliveira, et al.; J. Biol. Chem. 283, 13174 (2008) Abstract
Stx2 Causes Apoptosis In Human Brain Microvascular Endothelial Cells Via CHOP: J. Fujii, et al.; Infect. Immun. Epub ahead of print, (2008) Abstract