ALEXIS Biochemicals: Monoclonal Antibody to FasL (mouse) (A11)

ALX-804-009

Revised 27-Apr-06

Monoclonal Antibody to FasL (mouse) (A11)
SYNONYMS	anti-CD95L (mouse) MAb (A11) anti-APO-1L (mouse) MAb (A11) anti-CD178 (mouse) MAb (A11) anti-TNFSF 6 (mouse) MAb (A11)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	FasL Antibodies

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-009-C100		100 µg	300.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Mouse
CLONE:	A11
ISOTYPE:	Rat IgM
CONCENTRATION:	1mg/ml
PURITY:	≥95% (by SDS-PAGE).
FORMULATION:	Liquid. Purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN:	Synthetic peptide corresponding to aa 196-220 of mouse FasL (CD95L; APO-1L; CD178).
SPECIFICITY:	Recognizes mouse FasL.
APPLICATION:	Flow Cytometry Immunohistochemistry (frozen sections, paraffin sections) For Western blot, we recommend MAb to FasL (mouse) (H11) (Prod. No. ALX-804-010), MAb to FasL (human) (Mike-1) (Prod. No. ALX-804-124) and MAb to FasL (human) (Mike-2) (Prod. No. ALX-804-125).
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	+4°C
USE/STABILITY:	Stable for at least 6 months after receipt when stored at +4°C undiluted.
HANDLING:	Do not freeze/thaw.

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Product Specific Literature References

Characterization of the non-functional Fas ligand of gld mice: M. Hahne, et al.; Int. Immunol. 7, 1381 (1995) Abstract
Peripheral T cells undergoing superantigen-induced apoptosis in vivo express B220 and upregulate Fas and Fas ligand: T. Renno, et al.; J. Exp. Med. 183, 431 (1996) Abstract
Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover: L.E. French, et al.; J. Cell. Biol. 133, 335 (1996) Abstract
Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape: M. Hahne, et al.; Science 274, 1363 (1996) Abstract
Fas ligand expression by astrocytoma in vivo: maintaining immune privilege in the brain?: P. Saas, et al.; J. Clin. Invest. 99, 1173 (1997) Abstract; Full Text
Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis: Y. Refaeli, et al.; Immunity 8, 615 (1998) Abstract
The regulation of CD95 ligand expression and function in CTL: J.H. Li, et al.; J. Immunol. 161, 3943 (1998) Abstract
Vascular endothelial cells and smooth muscle cells differ in expression of Fas and Fas ligand and in sensitivity to Fas ligand-induced cell death: implications for vascular disease and therapy: M. Sata, et al.; Arterioscler. Thromb. Vasc. Biol. 20, 309 (2000) Abstract
Fas ligand overexpression on allograft endothelium inhibits inflammatory cell infiltration and transplant-associated intimal hyperplasia: M. Sata, et al.; J. Immunol. 166, 6964 (2001) Abstract
Intracellular localization of keratinocyte Fas ligand explains lack of cytolytic activity under physiological conditions: I. Viard-Leveugle, et al.; J. Biol. Chem. 278, 16183 (2003) Abstract; Full Text

General Information

MANUFACTURER

Manufactured by Apotech Corporation.