ALEXIS Biochemicals: Monoclonal Antibody to FasL (mouse) (H11)

ALX-804-010

Revised 10-May-06

Monoclonal Antibody to FasL (mouse) (H11)
SYNONYMS	anti-CD95L (mouse) MAb (H11) anti-APO-1L (mouse) MAb (H11) anti-CD178 (mouse) MAb (H11) anti-TNFSF 6 (mouse) MAb (H11)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	FasL Antibodies

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-010-C100	Purified	100 µg	300.00 USD
ALX-804-010B-T100	Biotin	100 tests	360.00 USD
ALX-804-010F-T100	FITC	100 tests	360.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Mouse
CLONE:	H11
ISOTYPE:	Rat IgG2a
CONCENTRATION:	1mg/ml
PURITY:	≥95% (by SDS-PAGE).
FORMULATION:	Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:	Synthetic peptide corresponding to aa 196-220 of mouse FasL (CD95L; APO-1L; CD178).
SPECIFICITY:	Recognizes mouse FasL.
APPLICATION:	H11 & H11-Biotin: Flow Cytometry Immunocytochemistry Western Blot H11-FITC: Flow Cytometry Immunocytochemistry For immunohistochemistry, we recommend MAb to FasL (A11) (Prod. No. ALX-804-009). For the detection of human FasL by flow cytometry or Western blot, we recommmend MAb to FasL (human) (Mike-1) (Prod. No. ALX-804-124) and MAb to FasL (human) (Mike-2) (Prod. No. ALX-804-125).
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	+4°C
USE/STABILITY:	Stable for at least 6 months after receipt when stored at +4°C undiluted.
HANDLING:	Do not freeze/thaw.

Product Images

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Product Specific Literature References

Characterization of the non-functional Fas ligand of gld mice: M. Hahne, et al.; Int. Immunol. 7, 1381 (1995) Abstract
CD4+ T cells reactivated with superantigen are both more sensitive to FasL-mediated killing and express a higher level of FasL: J.K. Wang, et al.; Cell. Immunol. 179, 153 (1997) Abstract
Transgenic expression of CD95 ligand on thyroid follicular cells confers immune privilege upon thyroid allografts: L. Tourneur, et al.; J. Immunol. 167, 1338 (2001) Abstract

General Information

BACKGROUND/TECHNICAL INFORMATION	FITC-conjugated antibody: 1 test means: 1µl of a 0.1mg/ml stock solution were used to stain 200'000 cells in a sample volume of 50µl.
MANUFACTURER	Manufactured by Apotech Corporation.

General Literature References

Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide: H. Russell, et al.; PNAS 90, 4409 (1993) Abstract; Full Text
Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways: B. Lowin, et al.; Nature 370, 650 (1994) Abstract
A role for CD95 ligand in preventing graft rejection: D. Bellgrau, et al.; Nature 377, 630 (1995) Abstract
Fas ligand-induced apoptosis as a mechanism of immune privilege: T.S. Griffith, et al.; Science 270, 1189 (1995) Abstract
Apoptosis by death factor: S. Nagata; Cell 88, 355 (1997) Abstract

ALX-211-053	Polyclonal Antibody to Rat IgG (Mouse Ig adsorbed) (R-PE)
ALX-211-051	Polyclonal Antibody to Rat IgG (Mouse Ig adsorbed) (FITC)