ALEXIS Biochemicals: Monoclonal Antibody to Glucocorticoid Receptor (BuGR2)

ALX-803-006

Revised 11-Jun-07

Monoclonal Antibody to Glucocorticoid Receptor (BuGR2)
SYNONYMS	anti-GR MAb (BuGR2)
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	Glucocorticoids & Glucocorticoid Receptors / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-803-006-C100		100 µg	379.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Mouse Rat Sheep Others
CLONE:	BuGR2
ISOTYPE:	Mouse IgG2
FORMULATION:	Lyophilized from PBS, pH 7.2, containing 0.05% sodium azide.
RECONSTITUTION:	Reconstitute with distilled water.
IMMUNOGEN:	Partially purified rat GR (glucocorticoid receptor).
SPECIFICITY:	Recognizes mouse, rat, sheep, guinea pig and rabbit GR. Recognizes full-lengh GR, the 17kDa DNA binding trypsin fragment and the 45kDa steroid- and DNA-binding chymotrypsin fragment. Detects a band of ~97kDa by Western blot. Does not cross-react with primate, avian or amphibian GR.
APPLICATION:	Flow Cytometry Gel Shift Assay Immunocytochemistry Immunohistochemistry (paraffin sections (5µg/ml)) Immunoprecipitation Western Blot (5µg/ml)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

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Product Specific Literature References

Analysis of the disruptive action of an epididymal protease and the stabilizing influence of molybdate on nondenatured and denatured glucocorticoid receptor: W.J. Hendry, 3rd, et al.; Endocrinology 120, 629 (1987) Abstract
Phosphorylated sites within the functional domains of the approximately 100-kDa steroid-binding subunit of glucocorticoid receptors: L.I. Smith, et al.; Biochemistry 28, 4490 (1989) Abstract
Disruption of the glucocorticoid receptor assembly with heat shock protein 90 by a peptidic antiglucocorticoid: H.P. Dao-Phan, et al.; Mol. Endocrinol. 11, 962 (1997) Abstract; Full Text
Analysis of FKBP51/FKBP52 chimeras and mutants for Hsp90 binding and association with progesterone receptor complexes: R.L. Barent, et al.; Mol. Endocrinol. 12, 342 (1998) Abstract; Full Text
Glucocorticoid receptor/signal transducer and activator of transcription 5 (STAT5) interactions enhance STAT5 activation by prolonging STAT5 DNA binding and tyrosine phosphorylation: S.L. Wyszomierski, et al.; Mol. Endocrinol. 13, 330 (1999) Abstract; Full Text

General Information

BACKGROUND/TECHNICAL INFORMATION

Immunocytochemical staining of GR in L929 cells with Prod. No. ALX-803-006 results in staining of both the cytoplasm and nucleus, even in the presence of hormone.

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Monoclonal Antibodies

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