ALEXIS Biochemicals: Monoclonal Antibody to HIF-1α (mgc3)

ALX-804-216

Revised 31-May-07

Monoclonal Antibody to HIF-1α (mgc3)
SYNONYMS	anti-Hypoxia-inducible Factor 1α MAb (mgc3) anti-ARNT-interacting Protein MAb (mgc3)
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Hypoxia-inducible Factor [HIF]/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-216-R100		100 µl	379.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse
CLONE:	mgc3
ISOTYPE:	Mouse IgG1
CONCENTRATION:	1mg/ml
FORMULATION:	Liquid. Contains 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:	Human HIF-1α (hypoxia-inducible factor 1α) (aa 530-826).
SPECIFICITY:	Recognizes human and mouse (only in Gel-Supershift Assays) HIF-1α. Detects a band of ~116kDa by Western blot after hypoxic induction. Does not cross-react with HIF-1β or HIF-2α.
APPLICATION:	Gel Supershift Assay Immunocytochemistry (1:200) Immunoprecipitation Western Blot (1:2’000)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

Product Images

Please click on thumbnails to enlarge.

Product Specific Literature References

[1] General applicability of chicken egg yolk antibodies: the performance of IgY immunoglobuilins raised against thy hypoxia-inducible factor 1alpha: G. Camenisch, et al.; FASEB J. 13, 81 (1999) Abstract; Full Text
[2] Induction and nuclear translocation of hypoxia-inducible factor-1 (HIF-1): heterodimerization with ARNT is not necessary for nuclear accumulation of HIF-1alpha: D. Chilov, et al.; J. Cell. Sci. 112, 1203 (1999) Abstract; Full Text

General Information

Oxygen availability plays a major role in the regulation of expression of many different genes including erythropoietin, nitric oxide synthase (NOS), heme oxygenase 1 (HO-1), glucose transporters and vascular growth factors necessary for the maintenance of homeostasis in hypoxic conditions. Hypoxia-inducible factor 1α (HIF-1α) has been identified as a bHLH-PAS family member which is instrumental in the oxygen-dependent regulation of these genes. HIF-1α rapidly accumulates in the nucleus upon exposure to hypoxic conditions where it heterodimerizes with the aryl hydrocarbon nuclear receptor translocator, ARNT, also referred to as HIF-1β.

Further Categories Containing This Product:

Aryl Hydrocarbon Receptor/Related Products • Monoclonal Antibodies

another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.