ALEXIS Biochemicals: Monoclonal Antibody to HSP90α/β (H90-10)

ALX-804-808

Revised 13-Aug-07

Monoclonal Antibody to HSP90α/β (H90-10)
SYNONYMS	anti-Heat Shock Protein 90α/β MAb (H90-10) anti-HSP84 MAb (H90-10) anti-Heat Shock Protein 84 MAb (H90-10)
PRODUCT LINE	Stress & Heat Shock Proteins
PRODUCT CATEGORY	HSP90 / HtpG / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-808-C100		100 µg	320.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse Others
CLONE:	H90-10
ISOTYPE:	Mouse IgG2a
SOURCE/HOST:	From mouse.
CONCENTRATION:	1mg/ml
PURITY:	>95% (SDS-PAGE)
PURITY DETAIL:	Purified from concentrated hybridoma tissue culture supernatant.
FORMULATION:	Liquid. Purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN:	Purified human HSP90β (heat shock protein 90β).
SPECIFICITY:	Recognizes human, mouse and rabbit HSP90α and HSP90β.
APPLICATION:	Immunocytochemistry (works on endogenous) Immunoprecipitation (works on endogenous) Western Blot (works on endogenous)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least one year after receipt when stored as recommended.
HANDLING:	Avoid freeze/thaw cycles.

Product Specific Literature References

Analysis of FKBP51/FKBP52 chimeras and mutants for Hsp90 binding and association with progesterone receptor complexes: R.L. Barent, et al.; Mol. Endocrinol. 12, 342 (1998) Abstract; Full Text
Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome: M.A. Loo, et al.; EMBO J. 17, 6879 (1998) Abstract
The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties: S.J. Felts, et al.; J. Biol. Chem. 275, 3305 (2000) Abstract; Full Text
The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKR: O. Donze, et al.; EMBO J. 20, 3771 (2001) Abstract
Hsp90 inhibition depletes Chk1 and sensitizes tumor cells to replication stress: S.J. Arlander, et al.; J. Biol. Chem. 278, 52572 (2003) Abstract; Full Text
GCUNC-45 Is a Novel Regulator for the Progesterone Receptor/hsp90 Chaperoning Pathway: A. Chadli, et al.; Mol. Cell. Biol. 26, 1722 (2006) Abstract

General Information

MANUFACTURER

Manufactured by Apotech Corporation.

General Literature References

Heat shock protein 90 as a molecular target for cancer therapeutics: J.S. Isaacs, et al.; Cancer Cell 3, 213 (2003), Review Abstract
Cancer: the rules of attraction: L. Neckers and Y.S. Lee; Nature 425, 357 (2003), Review Abstract
More than folding: localized functions of cytosolic chaperones: J.C. Young, et al.; TIBS 28, 541 (2003), Review Abstract

Further Categories Containing This Product:

Endoplasmatic Reticulum Stress • Chaperone-mediated Autophagy [CMA] • Monoclonal Antibodies

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