ALEXIS Biochemicals: Monoclonal Antibody to IKKα (14A231)

ALX-804-236

Revised 27-Feb-07

Monoclonal Antibody to IKKα (14A231)
SYNONYMS	anti-Inhibitor of Nuclear Factor κ-B Kinase α MAb (14A231) anti-IKK1 MAb (14A231)
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	IkB Kinases [IKKs] / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-236-C100		100 µg	293.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse Monkey
CLONE:	14A231
ISOTYPE:	Mouse IgG1
CONCENTRATION:	0.5mg/ml
PURITY DETAIL:	Protein G affinity-purified.
FORMULATION:	Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN:	Recombinant human IKKα (inhibitor of NF-κB kinase α; IKK1).
SPECIFICITY:	Recognizes human, mouse and monkey IKKα. Detects a band of ~85kDa by Western blot.
APPLICATION:	Immunoprecipitation (1-2µg/ml) Western Blot (1µg/ml)
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for 6 months when stored at +4°C.

Product Specific Literature References

IFN-alpha suppresses activation of nuclear transcription factors NF-kappa B and activator protein 1 and potentiates TNF-induced apoptosis: S.K. Manna, et al.; J. Immunol. 165, 4927 (2000) Abstract; Full Text
KKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development: Y. Cao, et al.; Cell 107, 763 (2001) Abstract
Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFkappaB activation without interfering with the IkappaB degradation pathway: D. Koul, et al.; J. Biol. Chem. 276, 11402 (2001) Abstract; Full Text
Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation: S. Majumdar & B.B. Aggarwal; J. Immunol. 167, 2911 (2001) Abstract; Full Text
Complete reconstitution of human IkappaB kinase (IKK) complex in yeast. Assessment of its stoichiometry and the role of IKKgamma on the complex activity in the absence of stimulation: B.S. Miller & E. Zandi; J. Biol. Chem. 276, 36320 (2001) Abstract; Full Text
NEMO trimerizes through its coiled-coil C-terminal domain: F. Agou, et al.; J. Biol. Chem. 277, 17464 (2002) Abstract; Full Text
The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways: E. Dejardin, et al.; Immunity 17, 525 (2002) Abstract
Thalidomide suppresses NF-kappa B activation induced by TNF and H2O2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester: S. Majumdar, et al.; J. Immunol. 168, 2644 (2002) Abstract; Full Text
The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation: C. Makris, et al.; Mol. Cell. Biol. 22, 6573 (2002) Abstract; Full Text

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