ALEXIS Biochemicals: Monoclonal Antibody to MRP1 (human) (QCRL-3)

ALX-801-011

Revised 10-Jan-08

Monoclonal Antibody to MRP1 (human) (QCRL-3)
SYNONYMS	anti-Multidrug Resistance-associated Protein 1 (human) MAb (QCRL-3) anti-ABCC1 (human) MAb (QCRL-3)
PRODUCT LINE	Cancer
PRODUCT CATEGORY	MDR-associated Proteins [MRPs]/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-801-011-L001		1 ml	390.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	QCRL-3
ISOTYPE:	Mouse IgG2a
CONCENTRATION:	40µg/ml
FORMULATION:	Liquid. 0.22µm-filtered antibody in PBS containing 0.7% BSA and 0.1% sodium azide.
IMMUNOGEN:	Membranes prepared from the human small cell lung cancer cell line H69AR.
SPECIFICITY:	Recognizes a conformation-dependent internal epitope (aa 617-932) of human MRP1 (multidrug resistance-associated protein 1), overexpressed in various human non-P-glycoprotein MDR tumor cell lines. Does not cross-react with human P-glycoprotein, MDR3 P-glycoprotein, or mouse MRP gene products.
APPLICATION:	Flow Cytometry (cell permeabilization required) Immunocytochemistry (cytospin preparations) Immunohistochemistry (paraffin sections) Immunoprecipitation (see [1,6]) Functional Application (inhibits LTC4 transport (see [4,6])) Note: Not recommended for Western blot.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.

Product Specific Literature References

[1] Detection of the M(r) 190,000 multidrug resistance protein, MRP, with monoclonal antibodies: D.R. Hipfner, et al.; Cancer Res. 54, 5788 (1994) Abstract
[2] Characterization of the M(r) 190,000 multidrug resistance protein (MRP) in drug-selected and transfected human tumor cell: K.C. Almquist, et al.; Cancer Res. 55, 102 (1995) Abstract
[3] MRP and MDR1 gene expression in primary breast carcinomas: M. Filipits, et al.; Clin. Cancer Res. 2, 1231 (1996) Abstract
[4] Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport: D.W. Loe, et al.; J. Biol. Chem. 271, 9675 (1996) Abstract; Full Text
[5] MRP expression in acute myeloid leukemia. An update: M. Filipits, et al.; Adv. Exp. Med. Biol. 457, 141 (1999) Abstract
[6] Monoclonal antibodies that inhibit the transport function of the 190-kDa multidrug resistance protein, MRP. Localization of their epitopes to the nucleotide-binding domains of the protein: D.R. Hipfner, et al.; J. Biol. Chem. 274, 15420 (1999) Abstract; Full Text
[7] Structural, mechanistic and clinical aspects of MRP1: D.R. Hipfner, et al.; Biochim. Biophys. Acta 1461, 359 (1999) Abstract
[8] ATP- and glutathione-dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1: J. Renes, et al.; Br. J. Pharmacol. 126, 681 (1999) Abstract

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Monoclonal Antibodies

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