ALEXIS Biochemicals: Monoclonal Antibody to MRP2 (M2III-6)

ALX-801-016

Revised 24-Feb-06

Monoclonal Antibody to MRP2 (M2III-6)
SYNONYMS	anti-Multidrug Resistance-associated Protein 2 MAb (M₂III-6) anti-cMOAT MAb (M₂III-6) anti-ABCC2 MAb (M₂III-6)
PRODUCT LINE	Cancer
PRODUCT CATEGORY	MDR-associated Proteins [MRPs] / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-801-016-C250		250 µg	630.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Rat
CLONE:	M₂III-6
ISOTYPE:	Mouse IgG2a
CONCENTRATION:	~250µg/ml
FORMULATION:	Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide.
IMMUNOGEN:	Recombinant C-terminal rat MRP2 (multidrug resistance-associated protein-2; cMOAT) (aa 1339-1541).
SPECIFICITY:	Recognizes an internal epitope of human and rat MRP2. Does not cross-react with human P-glycoprotein, MDR3 P-glycoprotein, MRP1, MRP3 or MRP5.
APPLICATION:	Immunocytochemistry: Use 1:20-1:50 dilution on acetone fixed cytospin preparations. Immunohistochemistry Frozen sections: Use (1:20) on acetone fixed frozen sections can be followed by incubation with rabbit anti-mouse antibody and a monoclonal mouse APAAP complex. Paraffin sections (weak): Can also be used on formaldehyde-fixed paraffin-embedded tissues and tumors, after pretreatment with 0.01M citric acid (pH 6.0) in distilled water at 100°C for 5 min 3 times. After incubation of the primary antibody and washing, slides can be incubated with biotinylated rabbit anti-mouse antibody and streptavidin conjugated to horseradish peroxidase. Western Blot: Use 1:20-1:50 and anti-mouse HRP.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

Product Specific Literature References

Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene: C.C. Paulusma, et al.; Science 271, 1126 (1996) Abstract
Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA: R. Evers, et al.; J. Clin. Invest. 101, 1310 (1998) Abstract; Full Text
Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2: J.H. Hooijberg, et al.; Cancer Res. 59, 2532 (1999) Abstract; Full Text
Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies: G.L. Scheffer, et al.; Cancer Res. 60, 5269 (2000) Abstract; Full Text
Multiple pathways for fluoroquinolone secretion by human intestinal epithelial (Caco-2) cells: S Lowes, et al.; Br. J. Pharm. 135, 1263 (2002) Abstract; Full Text

General Literature References

Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines : M. Kool, et al.; Cancer Res. 57, 3537 (1997) Abstract

Further Categories Containing This Product:

Monoclonal Antibodies

another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.