ALEXIS Biochemicals: Monoclonal Antibody to MRP3 (human) (M3II-21)

ALX-801-020

Revised 02-Nov-07

Monoclonal Antibody to MRP3 (human) (M3II-21)
SYNONYMS	anti-Multidrug Resistance-associated Protein 3 (human) MAb (M₃II-21) anti-ABCC3 (human) MAb (M₃II-21)
PRODUCT LINE	Cancer
PRODUCT CATEGORY	MDR-associated Proteins [MRPs] / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-801-020-C250		250 µg	630.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	M₃II-21
ISOTYPE:	Mouse IgG1
CONCENTRATION:	~250µg/ml
FORMULATION:	Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide.
IMMUNOGEN:	Recombinant human MRP3 (multidrug resistance-associated protein 3) (aa 830-949).
SPECIFICITY:	Recognizes an internal epitope of human MRP3. Does not cross-react with human P-glycoprotein, MDR3 P-glycoprotein, MRP1, MRP2 (cMOAT) or MRP5. Does not cross-react with mouse, rat or guinea pig MRP2 (cMOAT).
APPLICATION:	Immunocytochemistry: Use 1:20-50 dilution on acetone or formaldehyde fixed cytospin preparations. Immunohistochemistry: Use 1:20 dilution on acetone fixed frozen sections followed by incubation with rabbit anti-mouse IgG and a monoclonal mouse APAAP complex. Alternatively, after incubation with primary antibody (use 1:20) and washing, slides can be incubated with biotinylated rabbit anti-mouse IgG and streptavidin conjugated to horseradish peroxidase. Western Blot: Use 1:20-50 dilution and anti-mouse-HRP.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C

Product Specific Literature References

MRP3, an organic anion transporter able to transport anti-cancer drugs: M. Kool, et al.; PNAS 96, 6914 (1999) Abstract; Full Text
Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies: G.L. Scheffer, et al.; Cancer Res. 60, 5269 (2000) Abstract; Full Text
Tissue distribution and induction of human multidrug resistant protein 3: G.L. Scheffer, et al.; Lab. Invest. 82, 193 (2002) Abstract

General Literature References

Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines: M. Kool, et al.; Cancer Res. 57, 3537 (1997) Abstract

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Monoclonal Antibodies

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