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ALX-801-021 Revised 24-Feb-06
Monoclonal Antibody to MRP5 (human) (M5I-1)
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SYNONYMS anti-Multidrug Resistance-associated Protein 5 (human) MAb (M5I-1)
anti-ABCC5 (human) MAb (M5I-1)
PRODUCT LINE Cancer
PRODUCT CATEGORY MDR-associated Proteins [MRPs] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-801-021-C250   250 µg 630.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: M5I-1
ISOTYPE: Rat IgG2a
CONCENTRATION: ~250µg/ml
FORMULATION: Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide.
IMMUNOGEN: Recombinant human MRP5 (multidrug resistance-associated protein 5) (aa 82-168).
SPECIFICITY: Recognizes an internal epitope of human MRP5. Does not cross-react with human P-glycoprotein, MDR3 P-glycoprotein, MRP1, MRP2 (cMOAT) or MRP3.
APPLICATION: Flow Cytometry (weak, cell permeabilization required)
Immunocytochemistry: Use 1:20-1:50 dilution on acetone fixed cytospin preparations.
Immunohistochemistry (frozen sections, weak): Use 1:20 dilution on acetone fixed frozen sections followed by incubation with rabbit anti-rat Ig and a monoclonal rat APAAP complex. Alternatively, after incubation with the primary antibody and washing, slides can be incubated with biotinylated rabbit anti-rat Ig and streptavidin conjugated to horseradish peroxidase.
Western Blot: Use 1:20-1:50 dilution and anti-rat-HRP.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
Product Specific Literature References
Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies: G.L. Scheffer, et al.; Cancer Res. 60, 5269 (2000) Abstract; Full Text
General Literature References
Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines: M. Kool, et al.; Cancer Res. 57, 3537 (1997) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
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