ALEXIS Biochemicals: Monoclonal Antibody to MVP/LRP (human) (LRP-56)

ALX-801-005

Revised 31-Oct-06

Monoclonal Antibody to MVP/LRP (human) (LRP-56)
SYNONYMS	anti-Major Vault Protein/Lung Resistance Protein (human) MAb (LRP-56)
PRODUCT LINE	Cancer
PRODUCT CATEGORY	Major Vault Protein [MVP] / Lung Resistance Protein [LRP] / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-801-005-C050		50 µg	350.00 USD
ALX-801-005-C100		100 µg	630.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	LRP-56
ISOTYPE:	Mouse IgG2b
CONCENTRATION:	~250µg/ml
FORMULATION:	Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide.
IMMUNOGEN:	Human MVP/LRP (major vault protein/lung resistance protein).
SPECIFICITY:	Recognizes an internal epitope (P110) of human MVP/LRP, which is overexpressed in various human non-P-glycoprotein MDR tumor cell lines.
APPLICATION:	Flow Cytometry (cell permeabilization required) Immunocytochemistry (cytospin preparations) Immunohistochemistry (frozen sections, paraffin sections). Recommended starting dilution is 1:20. Optimal conditions should be determined individually for each application.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
POSITIVE CONTROL:	Cell lines: Appropriate drug-sensitive parental cell lines and their multdrug resistant derivatives prepared by the same methods as the test specimens should be used as control materials. Tissue: Human colon, kidney, bronchus or adrenal are recommended.

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Product Specific Literature References

Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance: R.J. Scheper, et al.; Cancer Res. 53, 1475 (1993) Abstract
Membrane transport proteins associated with drug resistance expressed in human melanoma: D. Schadendorf, et al.; Am. J. Pathol. 147, 1545 (1995) Abstract
Identification of novel drug resistance-associated proteins by a panel of rat monoclonal antibodies: M.J. Flens, et al.; Int. J. Cancer 73, 249 (1997) Abstract
Immunohistochemical detection of the human major vault protein LRP with two monoclonal antibodies in formalin-fixed, paraffin-embedded tissues: A.B. Schroeijers, et al.; Am. J. Pathol. 152, 373 (1998) Abstract
Immunohistochemical analysis of drug resistance-associated proteins in ovarian carcinomas: D. Mayr, et al.; Pathol. Res. Pract. 196, 469 (2000) Abstract
The Mr 193,000 vault protein is up-regulated in multidrug-resistant cancer cell lines: A.B. Schroeijers, et al.; Cancer Res. 60, 1104 (2000) Abstract; Full Text
Detection of the Mr 110,000 lung resistance-related protein LRP/MVP with monoclonal antibodies: A.B. Schroeijers, et al.; J. Histochem. Cytochem. 49, 1379 (2001) Abstract
The formation of vault-tubes: a dynamic interaction between vaults and vault PARP: A. Van Zon, et al.; J. Cell Sci. 116, 4391 (2003) Abstract

Further Categories Containing This Product:

Tumor Markers • Monoclonal Antibodies

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