ALEXIS Biochemicals: Monoclonal Antibody to Na+/K+ ATPase-α1 (9-A5)

ALX-804-080

Revised 04-Mar-05

Monoclonal Antibody to Na+/K+ ATPase-α1 (9-A5)
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Na+ / K+-ATPase / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-080-R100		100 µl	379.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Rat Dog Others
CLONE:	9-A5
ISOTYPE:	Mouse IgG1
FORMULATION:	Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN:	Purified rat kidney Na⁺/K⁺ ATPase.
SPECIFICITY:	Recognizes an intracellular region near Asp³⁶⁹ of the α1 subunit of human, rat, dog and chicken Na⁺/K⁺ ATPase-α.
APPLICATION:	ELISA Immunohistochemistry (1:1'000) Immunoprecipitation (can be used for affinity purification of the α subunit of Na⁺/K⁺ ATPase from dog kidney extracts)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

General Information

The Na⁺/K⁺ ATPase is an integral membrane enzyme found in all cells of higher organisms and is responsible for the ATP-dependent transport of sodium and potassium across the cell membrane. This membrane-bound enzyme is related to a number of other ATPases including sarcoplasmic and endoplasmic reticulum calcium ATPase (SERCA) and plasma membrane calcium ATPase (PMCA). The Na⁺/ K⁺ ATPase consists of a large, multipass, transmembrane catalytic subunit, termed the a subunit, and an associated smaller glycoprotein, termed the b subunit. Studies indicate that there are three isoforms of the α subunit (α1, α2, α3) and two isoforms of the β subunit (β1 and β2) encoded by two multigene families.The different isoforms of the Na⁺/K⁺ ATPase exhibit tissue-specific and developmental patterns of expression. The α1 and β mRNAs are present in all cell types examined, whereas the α2 and α3 mRNAs exhibit a more restricted pattern of cell-specific expression. The α subunit has been found in kidney, brain, heart, and to a lesser extent liver, skeletal and smooth muscle.

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Monoclonal Antibodies

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