ALEXIS Biochemicals: Monoclonal Antibody to Nod2 (human) (2D9)

ALX-803-307

Revised 28-Jul-08

Monoclonal Antibody to Nod2 (human) (2D9)
SYNONYMS	anti-CARD15 (human) MAb (2D9) anti-Caspase Recruitment Domain-containing Protein 15 (human) MAb (2D9) anti-Ibd1 (human) MAb (2D9) anti-Inflammatory Bowel Disease Protein 1 (human) PAb (2D9)
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	Nod-complex / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-803-307-1		1 Vial	390.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	2D9
ISOTYPE:	Mouse IgG1κ
CONCENTRATION:	1mg/ml
PURITY DETAIL:	Affinity-purified.
FORMULATION:	Liquid. In 200μl PBS, pH 7.2, containing 0.02% sodium azide.
IMMUNOGEN:	Recombinant human Nod2 (CARD15) (aa 28-301).
SPECIFICITY:	Recognizes human Nod2.
APPLICATION:	Immunohistochemistry (2µg/ml) Immunoprecipitation Western Blot (transfected cells: 1:100 - 1:250) Optimal conditions must be determined individually for each application.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	+4°C
USE/STABILITY:	Stable for at least one year after receipt when stored at +4°C.
HANDLING:	After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

General Literature References

Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB: J. Bertin, et al.; J. Biol. Chem. 274, 12955 (1999) Abstract
Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB: N. Inohara, et al. ; J. Biol. Chem. 274, 14560 (1999) Abstract
An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways : N. Inohara, et al. ; J. Biol. Chem. 275, 27823 (2000) Abstract
Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB: Y. Ogura, et al.; J. Biol. Chem. 276, 4812 (2001) Abstract
Induction of Nod2 in myelomonocytic and intestinal epithelial cells via nuclear factor-kappa B activation: O. Gutierrez, et al. ; J. Biol. Chem. 277, 41701 (2001) Abstract
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease: Y. Ogura, et al. ; Nature 411, 603 (2001) Abstract
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease: J.P. Hugot, et al. ; Nature 411, 599 (2001) Abstract
Human Nod1 confers responsiveness to bacterial lipopolysaccharides : N. Inohara, et al. ; J. Biol. Chem. 276, 2551 (2001) Abstract
Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis: Y. Ogura, et al. ; Gut 52, 1591 (2003) Abstract

Further Categories Containing This Product:

Caspase Recruitment Domain [CARD] Proteins / Related Products • Monoclonal Antibodies

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