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ALX-804-636 Revised 31-Oct-06
Monoclonal Antibody to PP2A (Subunit A) (PR65) (α Isoform) (4C10)
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SYNONYMS anti-Protein Phosphatase 2A (Subunit A) (PR65) (α Isoform) MAb (4C10)
anti-PP2A A/PR65α MAb (4C10)
anti-Medium Tumor Antigen-associated 61kDa Protein MAb (4C10)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PP2A / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-636-C050   50 µg 290.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: 4C10
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human PP2A (subunit A) (PR65) (α isoform) (aa 1-168).
SPECIFICITY: Recognizes human and mouse PP2A (subunit A) (PR65) (α isoform). Recognizes mouse PP2A (subunit A) (PR65) (β isoform) (weak).
CROSSREACTIVITY PROTEINS: PP2A (subunit A) (PR65) (β isoform) (weak)
APPLICATION: Western Blot (1:5’000)
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles.
General Information
The regulatory A subunit (PR65) is tightly associated with catalytic subunit (PP2Ac), forming a scaffold to which the appropriate B subunit can bind. Different B subunits interact via the same or overlapping sites within the A subunit of the core dimer, which explains why binding of the B subunits is mutually exclusive. Two distinct PR65 isoforms (α and β) which share 86% sequence identity are ubiquitiously expressed. Recent studies reported that the genes encoding both the α and β isoforms of PR65/A were altered at low frequency in a variety of primary human tumors, identifying these subunits as tumorsuppressors. Partial or total loss (by cleavage through caspase-3) of the PR65/A subunit resulted in an increase in PP2A activity towards specific pro-apoptotic substrates involved in the cellular apoptotic response.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
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