ALEXIS Biochemicals: Monoclonal Antibody to PSD-95 (7E3-1B8)

ALX-804-066

Revised 21-Jul-08

Monoclonal Antibody to PSD-95 (7E3-1B8)
SYNONYMS	anti-Post-synaptic Density 95kDa Protein MAb (7E3-1B8)
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	NMDA Receptors / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-066-R100		100 µl	379.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Mouse Rat
CLONE:	7E3-1B8
ISOTYPE:	Mouse IgG2a
CONCENTRATION:	1mg/ml
FORMULATION:	Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:	Purified recombinant rat PSD-95 (post-synaptic density 95kDa protein).
SPECIFICITY:	Recognizes mouse, rat and Xenopus PSD-95. Detects a band of ~95kDa by Western blot.
APPLICATION:	Immunocytochemistry (1:500; fixation with cold methanol is recommended) Immunohistochemistry (frozen sections (1:200)) (see [9]) Immunoprecipitation Western Blot (1:2’000)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

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Product Specific Literature References

[1] Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95: H.-C. Kornau, et al.; Science 269, 1737 (1995) Abstract
[2] Citron, a Rho-target, interacts with PSD-95/SAP-90 at glutamatergic synapses in the thalamus: T. Furuyashiki, et al.; J. Neurosci. 19, 109 (1999) Abstract; Full Text
[3] Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes: M. Russwurm, et al.; J. Biol. Chem. 276, 44647 (2001) Abstract; Full Text
[4] Inactivation of the murine X-linked juvenile retinoschisis gene, Rs1h, suggests a role of retinoschisin in retinal cell layer organization and synaptic structure: B.H. Weber, et al.; PNAS 99, 6222 (2002) Abstract; Full Text
[5] Ligand binding of the second PDZ domain regulates clustering of PSD-95 with the Kv1.4 potassium channel: F. Imamura, et al.; J. Biol. Chem. 277, 3640 (2002) Abstract; Full Text
[6] Cellular localization of the MPP4 protein in the mammalian retina: H. Stohr, et al.; IOVS 44, 5067 (2003) Abstract; Full Text
[7] Unique domain anchoring of Src to synaptic NMDA receptors via the mitochondrial protein NADH dehydrogenase subunit 2: J.R. Gingrich, et al.; PNAS 101, 6237 (2004) Abstract; Full Text
[8] Mass of the postsynaptic density and enumeration of three key molecules: X. Chen, et al.; PNAS 102, 11551 (2005) Abstract; Full Text
[9] Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression: M. Colledge, et al.; Neuron 40, 595 (2003) Abstract

Further Categories Containing This Product:

Synaptic Proteins / Related Products • Monoclonal Antibodies

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