ALEXIS Biochemicals: Monoclonal Antibody to Prion Protein (F89/160.1.5)

ALX-803-042

Revised 05-Jan-06

Monoclonal Antibody to Prion Protein (F89/160.1.5)
SYNONYMS	anti-PrP MAb (F89/160.1.5)
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	Prion Protein / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-803-042-C200		200 µg	379.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Sheep Others
CLONE:	F89/160.1.5
ISOTYPE:	Mouse IgG1
CONCENTRATION:	1mg/ml
FORMULATION:	Liquid. Contains 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:	Synthetic peptide corresponding to aa 146-159 (S¹⁴⁶RPLIHFGSDYEDR¹⁵⁹) of bovine PrP (prion protein).
SPECIFICITY:	Recognizes a conserved epitope (IHFG) of human, bovine, sheep, deer and elk PrP. Detects bands of ~33-35kDa (normal samples) and ~27-30kDa (protease treated infected samples) by Western blot.
APPLICATION:	ELISA Immunohistochemistry (paraffin sections (3-5µg/ml)) Western Blot (3-5µg/ml)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:	For Blocking Peptide see Prod. No. ALX-165-046.

Product Specific Literature References

Monoclonal antibody F89/160.1.5 defines a conserved epitope on the ruminant prion protein: K.I. O’Rourke, et al.; J. Clin. Microbiol. 36, 1750 (1998) Abstract; Full Text
Immunoreactivity of the monoclonal antibody F89/160.1.5 for the human prion protein: B. Van Everbroeck, et al.; Eur. J. Histochem. 43, 335 (1999) Abstract

General Information

BACKGROUND/TECHNICAL INFORMATION

Immunohistochemical staining of PrP(Sc) in infected sheep brain results in intense staining of the spongiform lesions. In immunohistochemical procedures this antibody detects only the PrP(Sc) and not PrP(C).

Further Categories Containing This Product:

CD Antibodies • Monoclonal Antibodies

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