ALEXIS Biochemicals: Monoclonal Antibody to Procathepsin L (human) (CPLH 2D4)

ALX-804-289

Revised 07-Feb-06

Monoclonal Antibody to Procathepsin L (human) (CPLH 2D4)
SYNONYMS	anti-Cathepsin L Precursor (human) MAb (CPLH 2D4)
PRODUCT LINE	Cancer
PRODUCT CATEGORY	Cathepsin Antibodies

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-289-C200		200 µg	460.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	CPLH 2D4
ISOTYPE:	Mouse IgG1
CONCENTRATION:	1mg/ml
FORMULATION:	Liquid. Protein G purified antibody in PBS containing 0.01% thimerosal.
IMMUNOGEN:	Purified human procathepsin L (from culture supernatant of non-small cell lung cancer cell line EPLC 32 M1).
SPECIFICITY:	Recognizes the epitope T⁶⁷SEEFRQVMNGFQ⁷⁹ of the propeptide of human procathepsin L. Does not cross-react with mature single or two chain cathepsin L or with mature cathepsins B, D, H, K, S and procathepsins B, D, F, S, W.
APPLICATION:	ELISA (capture antibody) Immunohistochemistry (paraffin sections after microwave treatment)Western Blot Optimal conditions must be determined individually for each application. Dilutions given in the figures below may be used as guidelines.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	+4°C
HANDLING:	Do not freeze.

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Product Specific Literature References

Hybridoma cells producing antibodies to cathepsin L have greatly reduced potential for tumour growth: E. Weber, et al.; J. Cancer. Res. Clin. Oncol. 120, 564 (1994) Abstract
Monoclonal antibodies against cathepsin L and procathepsin L of different species: E. Weber, et al.; Hybridoma 16, 159 (1997) Abstract
Immunohistochemical and clinical evaluation of cathepsin expression in soft tissue sarcomas: P. Wurl, et al.; Virchows Arch. 430, 221 (1997) Abstract

General Information

Cathepsin L [EC 3.4.22.15] is a lysosomal endopeptidase belonging to the papain family of the closely related cysteine proteases superfamily. The enzyme is ubiquitously distributed in the lysosomes of all cells and seems to be involved in a variety of disorders in which the pathological destruction of the extracellular matrix is one of the main characteristics.

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Monoclonal Antibodies

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