ALEXIS Biochemicals: Monoclonal Antibody to Prolactin Receptor (U5)

ALX-803-005

Revised 23-Jan-06

Monoclonal Antibody to Prolactin Receptor (U5)
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Prolactin & Prolactin Receptors / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-803-005-C100		100 µg	379.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Rat Pig Others
CLONE:	U5
ISOTYPE:	Mouse IgG1
FORMULATION:	Lyophilized. Contains 0.05% sodium azide.
RECONSTITUTION:	Reconstitute with 100µl PBS.
IMMUNOGEN:	Purified rat liver prolactin receptor.
SPECIFICITY:	Recognizes the extracellular domain of human, rat, rabbit and pig prolactin receptor. Does not inhibit the interaction of prolactin with the receptor.
APPLICATION:	Flow Cytometry Immunocytochemistry (5µg/ml) Immunohistochemistry Immunoprecipitation Western Blot (1µg/ml)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

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Product Specific Literature References

Characterization and applications of monoclonal antibodies to the prolactin receptor: H. Okamura, et al.; Endocrinology 124, 2499 (1989) Abstract
The prolactin receptor in the fetal rat: cellular localization of messenger ribonucleic acid, immunoreactive protein, and ligand-binding activity and induction of expression in late gestation: M. Royster, et al.; Endocrinology 136, 3892 (1995) Abstract
Internalization of prolactin receptor and prolactin in transfected cells does not involve nuclear translocation: M. Perrot-Applanat, et al.; J. Cell Sci. 110, 1123 (1997) Abstract; Full Text
The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation: L. De Petrocellis, et al.; PNAS 95, 8375 (1998) Abstract; Full Text

General Information

Prolactin (PRL) is a hormone involved in a variety of important functions including ion transport and osmoregulation, stimulation of milk, protein synthesis as well as the regulation of numerous reproductive functions. PRL exerts its influence on different cell types through a signal transduction pathway which begins with the binding of the hormone to a transmembrane PRL receptor. Immunoreactive PRL receptor, a member of the cytokine receptor family, varies in size (short and long forms) with tissue source and species, from ~40 kDa to 100 kDa. The PRL receptor consists of at least three separate domains: an extracellular region with 5 cysteines which contains the prolactin binding site, a single transmembrane domain and a cytoplasmic region, the length of which appears to influence ligand binding and regulate cellular function.

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