ALEXIS Biochemicals: Monoclonal Antibody to SARM (human) (Sarmy-1)

ALX-804-831

Revised 22-Sep-05

Monoclonal Antibody to SARM (human) (Sarmy-1)
SYNONYMS	anti-TIR-1 (human) MAb (Sarmy-1) anti-Sterile α and TIR Motif-containing Protein 1 (human) MAb (Sarmy-1) anti-SAM and ARM-containing Protein (human) MAb (Sarmy-1) anti-Sterile α Motif and Armadillo Repeat-containing Protein (human) MAb (Sarmy-1)
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	Toll-IL-1 Receptor Adaptors / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-831-C100		100 µg	320.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	Sarmy-1
ISOTYPE:	Mouse IgG2b
SOURCE/HOST:	Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION:	1mg/ml
PURITY:	≥95% (SDS-PAGE)
FORMULATION:	Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
IMMUNOGEN:	Recombinant human SARM (aa 93-292).
SPECIFICITY:	Recognizes human SARM.
APPLICATION:	Immunoprecipitation (1:200) Note: Does not work for Western Blot.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:	Avoid freeze/thaw cycles.

General Information

In mammals, TIR domain adapters, including Myd88, TIRAP, TICAM-1 (also called TRIF), and TRAM, act in Toll-like receptor (TLR) signaling pathway. The last member of this family called SARM (sterile and armadillo motifs) is highly conserved but has no known function in any organism. SARM is the only mammalian TIR-domain adapter proteins conserved in C. elegans, suggesting that SARM is the most ancient member of this class of signaling proteins. Overexpression of SARM fails to activate either NF-kB- or IRF-3-dependent reporter gene expression, two transcription factors that are sensitive to TLR signaling, suggesting that SARM is functionally distinct from other mammalian TIR domain-containing proteins.

MANUFACTURER

Manufactured by Apotech Corporation.

General Literature References

Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response: N.T. Liberati, et al.; PNAS 101, 6593 (2004) Abstract
TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM: C. Couillault, et al.; Nat. Immunol. 5, 488 (2004) Abstract

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Monoclonal Antibodies

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