ALEXIS Biochemicals: Monoclonal Antibody to TRAIL-R1 (human) (HS101)

ALX-804-297

Revised 24-Jun-08

Monoclonal Antibody to TRAIL-R1 (human) (HS101)
SYNONYMS	anti-DR4 (human) MAb (HS101) anti-TNFRSF 10A (human) MAb (HS101) anti-CD261 (human) MAb (HS101)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	TRAIL-R1

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-297-C100	Preservative Free	100 µg	330.00 USD
ALX-804-297A-C100	Purified	100 µg	330.00 USD
ALX-804-297F-T100	FITC	100 tests	380.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	HS101
ISOTYPE:	Mouse IgG1
CONCENTRATION:	HS101 & HS101 (preservative free): 1mg/ml HS101-FITC: 0.5mg/ml
PURITY:	≥95%
FORMULATION:	HS101: Liquid. In PBS containing 0.02% sodium azide. HS101 (preservative free): Liquid. In PBS. HS101-FITC: Liquid. 50µg in PBS containing 0.09% sodium azide.
IMMUNOGEN:	Recombinant human TRAIL-R1 (DR4).
SPECIFICITY:	Recognizes human TRAIL-R1. Does not cross-react with human TRAIL-R2, -R3 or -R4.
APPLICATION:	Flow Cytometry Immunocytochemistry Immunoprecipitation Functional Application: Inhibition (blocks TRAIL-R1 mediated killing if applied in solution). For Western blot of whole cell lysate use PAb to TRAIL-R1 (CT) (Prod. No. PSC-1139).
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

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Product Specific Literature References

Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8: M.R. Sprick, et al.; EMBO J. 21, 4520 (2002) Abstract
Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling in Activated T Cells Abrogates TRAIL-Induced Apoptosis Upstream of the Mitochondrial Amplification Loop and Caspase-8: T.S. Soderstrom, et al.; J. Immunol. 169, 2851 (2002) Abstract
Proteasome inhibition results in TRAIL sensitization of primary keratinocytes by removing the resistance-mediating block of effector caspase maturation: M. Leverkus, et al.; Mol. Cell. Biol. 23, 777 (2003) Abstract; Full Text
TNF-Related Apoptosis-Inducing Ligand Mediates Tumoricidal Activity of Human Monocytes Stimulated by Newcastle Disease Virus: B. Washburn, et al.; J. Immunol. 170, 1814 (2003) Abstract
TRAIL regulates normal erythroid maturation through an ERK-dependent pathway: P. Secchiero, et al.; Blood 103, 517 (2004) Abstract
IFN{alpha}-stimulated neutrophils and monocytes release a soluble form of TNF-related apoptosis-inducing ligand (TRAIL/Apo-2 ligand) displaying apoptotic activity on leukemic cells: C. Tecchio, et al.; Blood 103, 3837 (2004) Abstract
Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs: T.M. Ganten, et al.; Cell Death Differ. 11 Suppl 1, S86 (2004) Abstract
Casein kinase I attenuates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by regulating the recruitment of fas-associated death domain and procaspase-8 to the death-inducing signaling complex: K. Izeradjene, et al.; Cancer Res. 64, 8036 (2004) Abstract; Full Text
cFLIPL inhibits tumor necrosis factor-related apoptosis-inducing ligand-mediated NF-kappaB activation at the death-inducing signaling complex in human keratinocytes: T. Wachter, et al.; J. Biol. Chem. 279, 52824 (2004) Abstract; Full Text
Resistance to FasL and tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in Sezary syndrome T-cells associated with impaired death receptor and FLICE-inhibitory protein expression: E. Contassot, et al.; Blood 111, 4780 (2008) Abstract

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