ALEXIS Biochemicals: Monoclonal Antibody to Toll-like Receptor 3 (human) (40C1285.6)

ALX-804-362

Revised 13-May-08

Monoclonal Antibody to Toll-like Receptor 3 (human) (40C1285.6)
SYNONYMS	anti-TLR3 MAb (40C1285.6) anti-CD283 (human) MAb (40C1285.6)
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	TLR Antibodies

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-362-C100		100 µg	293.00 USD
ALX-804-362B-C100	Biotin	100 µg	319.00 USD
ALX-804-362F-C100	FITC	100 µg	358.00 USD
ALX-804-362R-C100	R-PE	100 µg	397.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	40C1285.6
ISOTYPE:	Mouse IgG1
CONCENTRATION:	0.5mg/ml
PURITY DETAIL:	Protein G-affinity purified.
FORMULATION:	40C1285.6: Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide. 40C1285.6-Biotin: Liquid. In PBS containing 0.02% sodium azide. 40C1285.6-FITC: Liquid. In 10mM TRIS containing 150mM sodium chloride and 0.02% sodium azide. 40C1285.6-R-PE: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:	Synthetic peptides corresponding to human TLR3 (Toll-like receptor 3) cytoplasmic portion.
SPECIFICITY:	Recognizes human TLR3.
APPLICATION:	Flow Cytometry (2-5µg/10⁶ cells for intracellular staining, for cell surface see [7]) Immunocytochemistry (see [3],[8] and [9]) Immunohistochemistry (paraffin sections) (see [4]) Immunoprecipitation (2µg/10⁶ transfected cells) Western Blot (1-3µg/ml)
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
HANDLING:	For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep Biotin-, FITC- and R-PE-conjugated formats at +4°C. Do not freeze. Protect from light.

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Product Specific Literature References

[1] Subcellular localization of Toll-like receptor 3 in human dendritic cells: M. Matsumoto, et al.; J. Immunol. 171, 3154 (2003) Abstract
[2] The effect of innate immunity on autoimmune diabetes and the expression of Toll-like receptors on pancreatic islets: L. Wen, et al.; J. Immunol. 172, 3173 (2004) Abstract
[3] Regulation of the polymeric Ig receptor by signaling through TLRs 3 and 4: linking innate and adaptive immune responses: T.A. Schneeman, et al.; J. Immunol. 175, 376 (2005) Abstract
[4] Toll-like receptors-2, -3 and -4 expression patterns on human colon and their regulation by mucosal-associated bacteria: E. Furrie, et al.; Immunology 115, 565 (2005) Abstract
[5] Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-beta production in hepatocytes: K. Li, et al.; J. Biol. Chem. 280, 16739 (2005 280, 16739 (2005) Abstract; Full Text
[6] Thyrocytes express a functional toll-like receptor 3: overexpression can be induced by viral infection and reversed by phenylmethimazole and is associated with Hashimoto’s autoimmune thyroiditis: N. Harii, et al.; Mol. Endocrinol. 19, 1231 (2005) Abstract
[7] Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils: C.K. Wong, et al.; Am. J. Respir. Cell Mol. Biol. 37, 85 (2007) Abstract
[8] Biochemical and functional analyses of the human Toll-like receptor 3 ectodomain: C.T. Ranjith-Kumar, et al.; J. Biol. Chem. 282, 7668 (2007) Abstract; Full Text
[9] Effects of single nucleotide polymorphisms on Toll-like receptor 3 activity and expression in cultured cells: C.T. Ranjith-Kumar, et al.; J. Biol. Chem. 282, 17696 (2007) Abstract; Full Text

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Antiviral Signalling/Related Products • CD Antibodies • Monoclonal Antibodies

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