ALEXIS Biochemicals: Monoclonal Antibody to Vitamin D3 Receptor (9A7)

ALX-804-021

Revised 21-Jul-08

Monoclonal Antibody to Vitamin D3 Receptor (9A7)
SYNONYMS	anti-VDR MAb (9A7)
PRODUCT LINE	Bone Metabolism
PRODUCT CATEGORY	Vitamin D3 & Vitamin D3 Receptor/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-021-C100		100 µg	379.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse Rat Others
CLONE:	9A7
ISOTYPE:	Rat IgG2b
CONCENTRATION:	1mg/ml
FORMULATION:	Liquid. Purified antibody containing 0.05% sodium azide.
IMMUNOGEN:	Partially purified chicken intestinal cytoplasmic VDR (vitamin D₃ receptor).
SPECIFICITY:	Recognizes the occupied and unoccupied forms of VDR in human, mouse, rat, hamster, chicken, amphibian and fish. Recognizes an epitope between aa 89 and 105 of human VDR. In avians detects bands of ~58kDa and ~60kDa by Western blot, while in mammalian species the VDRs appear as a single band within the ~52-55kDa range. Does not cross-react with ER (estrogen receptor) or GR (glucocorticoid receptor).
APPLICATION:	Gel Supershift Assays Immunocytochemistry Immunohistochemistry (paraffin and frozen sections (5µg/ml)) Immunoprecipitation, Chromatin Immunoprecipitation Western Blot (1µg/ml)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

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Product Specific Literature References

Development of hybridomas secreting monoclonal antibodies to the chicken intestinal 1 alpha,25-dihydroxyvitamin D3 receptor: J.W. Pike, et al.; PNAS 79, 7719 (1982) Abstract
Serum and monoclonal antibodies against the chick intestinal receptor for 1,25-dihydroxyvitamin D3. Generation by a preparation enriched in a 64,000-dalton protein: J.W. Pike, et al.; J. Biol. Chem. 258, 1289 (1983) Abstract; Full Text
Immunocytochemical localization of the 1,25-dihydroxyvitamin D3 receptor in target cells: T.L. Clemens, et al.; Endocrinology 122, 1224 (1988) Abstract
Molecular biology of the vitamin D hormone: M.R. Haussler, et al.; Recent Progr. Horm. Res. 44, 263 (1988) Abstract
Immunohistochemical detection of 1,25-dihydroxyvitamin D3 receptors and estrogen receptors by monoclonal antibodies: comparison of four immunoperoxidase methods: P. Milde, et al.; J. Histochem. Cytochem. 37, 1609 (1989) Abstract
Baculovirus-mediated expression of the human vitamin D receptor. Functional characterization, vitamin D response element interactions, and evidence for a receptor auxiliary factor: P.N. MacDonald, et al.; J. Biol. Chem. 266, 18808 (1991) Abstract; Full Text

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