ALEXIS Biochemicals: Monoclonal Antibody to c-erbB-2 (human) (MGR2)

ALX-804-573

Revised 23-Apr-08

Monoclonal Antibody to c-erbB-2 (human) (MGR2)
SYNONYMS	anti-ErbB2 (human) MAb (MGR2) anti-HER-2 (human) MAb (MGR2) anti-neu (human) MAb (MGR2)
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	erbB-2/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-573-C100		100 µg	320.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	MGR2
ISOTYPE:	Mouse IgG1
CONCENTRATION:	1mg/ml
FORMULATION:	Liquid. In 150mM sodium chloride, pH 7.4, containing 0.02% sodium azide.
IMMUNOGEN:	CaLu 3 lung carcinoma cell line.
SPECIFICITY:	Recognizes an epitope present in the extracellular domain of human c-erbB-2 (HER-2; neu).
APPLICATION:	Flow Cytometry Immunohistochemistry (frozen sections) Immunoprecipitation: Detects a band of ~185kDa. Optimal conditions must be determined individually for each application.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	+4°C
HANDLING:	Do not freeze.

Product Specific Literature References

Selection of monoclonal antibodies which induce internalization and phosphorylation of p185HER2 and growth inhibition of cells with HER2/NEU gene amplification: E. Tagliabue, et al.; Int. J. Cancer 47, 933 (1991) Abstract
p185 HER2/neu epitope mapping with murine monoclonal antibodies: F. Centis, et al.; Hybridoma 11, 267 (1992) Abstract
Antigenic and immunogenic mimicry of the HER2/neu oncoprotein by phage-displayed peptides: R. Orlandi, et al.; Eur. J. Immunol. 24, 2868 (1994) Abstract

General Information

The epidermal growth factor type II receptor, c-erbB2 (HER-2; neu), is a transmembrane tyrosine kinase receptor known to play an important role in coordinating the complex ErbB signalling network and to be involved in the development of breast cancer. When c-erbB-2 is overexpressed at high levels, ligand-independent activation of the c-erbB-2 receptor results in an increased mitogen-activated protein kinase and PI(3)K cell signalling, leading to increased cell proliferation. Overexpression of c-erbB-2 has been associated with resistance to chemotherapy and poor survival in several human tumors.

Further Categories Containing This Product:

Monoclonal Antibodies • Tumor Markers

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