ALEXIS Biochemicals: Monoclonal Antibody to pan-CEACAM (1,3,4,5,6) (human) (D14HD11)

ALX-805-080

Revised 14-Sep-07

Monoclonal Antibody to pan-CEACAM (1,3,4,5,6) (human) (D14HD11)
PRODUCT LINE	Cytoskeleton
PRODUCT CATEGORY	CEACAM [CD66]/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-805-080-C100		100 µg	290.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	D14HD11
ISOTYPE:	Mouse IgG1
CONCENTRATION:	1mg/ml
PURITY DETAIL:	Protein G-affinity purified.
FORMULATION:	Liquid. In PBS, pH 7.2, containing 0.01% sodium azide.
IMMUNOGEN:	CEACAM5 partially purified from a perchloric acid extract from liver metastases of colonic tumors.
SPECIFICITY:	Recognizes human CEACAM1, 3, 4, 5 and 6.
APPLICATION:	ELISA Flow Cytometry Immunohistochemistry (frozen sections) Western Blot Optimal conditions must be determined individually for each application.
QUALITY CONTROL:	Routinely tested by flow cytometry on BOSC23 cells transiently transfected with a CEACAM5 expression vector.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.

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Product Specific Literature References

Production and characterization of monoclonal antibodies against carcinoembryonic antigen (CEA): P. Jantscheff, et al.; Biomed. Biochim. Acta 50, 1261 (1991) Abstract
CD66 family Workshop: binding of myeloid blind panel antibodies and CD66 Subsection antibodies to HeLa transfectants expressing individual CD66 molecules: F. Grunert, et al.; Leukocyte Typing VI: White cell Differentiation Antigens (T. Kishimoto, et al., eds.), Garland Publishing Inc., New York 1012 (1996)
CD66 carcinoembryonic antigens mediate interactions between Opa-expressing Neisseria gonorrhoeae and human polymorphonuclear phagocytes: S.D. Gray-Owen, et al.; EMBO J. 16, 3435 (1997) Abstract; Full Text
CEA-related proteins on human urothelial cell lines of different transformation grades: A. Krop-Watorek, et al.; Cancer Lett. 139, 15 (1999) Abstract
Molecular analysis of neisserial Opa protein interactions with the CEA family of receptors: identification of determinants contributing to the differential specificities of binding: A. Popp, et al.; Cell. Microbiol. 1, 169 (1999) Abstract; Full Text
Recruitment of CD55 and CD66e brush border-associated glycosylphosphatidylinositol-anchored proteins by members of the Afa/Dr diffusely adhering family of Escherichia coli that infect the human polarized intestinal Caco-2/TC7 cells J. Guignot, et al.; Infect. Immun. 68, 3554 (2000) Abstract; Full Text
Carcinoembryonic antigen family receptor specificity of Neisseria meningitidis Opa variants influences adherence to and invasion of proinflammatory cytokine-activated endothelial cells: P. Muenzner, et al.; Infect. Immun. 68, 3601 (2000) Abstract; Full Text
Pathogenic Neisseria trigger expression of their carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1; previously CD66a) receptor on primary endothelial cells [...]: P. Muenzner, et al.; J. Biol. Chem. 276, 24331 (2001) Abstract; Full Text
Homophilic adhesion of human CEACAM1 involves N-terminal domain interactions: structural analysis of the binding site: S.M. Watt, et al.; Blood 98, 1469 (2001) Abstract; Full Text
Distinct mechanisms of internalization of Neisseria gonorrhoeae by members of the CEACAM receptor family involving Rac1- and Cdc42-dependent and -independent pathways: O. Billker, et al.; EMBO J. 21, 560 (2002) Abstract; Full Text
Neisserial binding to CEACAM1 arrests the activation and proliferation of CD4+ T lymphocytes: I.C. Boulton & S.D. Gray-Owen; Nat. Immunol. 3, 229 (2002) Abstract
The tumorigenic potential of human CX-1 colon adenocarcinoma cells depends on carcinoembryonic antigen (CEACAM5) expression: D. Baczynska, et al.; Cell. Mol. Biol. Lett. 8, 471 (2003) Abstract; Full Text

General Information

CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family. It consists of seven CEACAM (CEACAM1, CEACAM3-CEACAM8) and 11 pregnancy-specific glycoprotein (PSG1-PSG11) members. The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leukocytes. Overexpression of CEA/CEACAM5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. The function of CEACAM family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocytes and dendritic cell activation, receptors of Neisseria species and other bacteria.

MANUFACTURER

Manufactured by GENOVAC GmbH.

General Literature References

Carcinoembryonic antigen gene family: molecular biology and clinical perspectives: J.A. Thompson, et al.; J. Clin. Lab. Anal. 5, 344 (1991), (Review) Abstract
The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues: S. Hammarström; Semin. Cancer Biol. 9, 67 (1999), (Review) Abstract
Carcionembryonic antigen: W. Zimmermann; Wiley Encyclopedia of Molecular Medicine (T. Creighton, ed.), John Wiley & Sons Inc. New York 459 (2002)

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CD Antibodies • Monoclonal Antibodies

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