ALEXIS Biochemicals: Monoclonal Antibody to pan-CEACAM (1,5,6,8) (human) (TET2)

ALX-805-081

Revised 18-Aug-06

Monoclonal Antibody to pan-CEACAM (1,5,6,8) (human) (TET2)
SYNONYMS	anti-CD66a/CD66b/CD66c/CD66e (human) MAb (TET2) anti-BGP/CEA/NCA/CGM5 (human) MAb (TET2)
PRODUCT LINE	Cytoskeleton
PRODUCT CATEGORY	CEACAM [CD66]/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-805-081-C100		100 µg	290.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	TET2
ISOTYPE:	Mouse IgG2b
CONCENTRATION:	1mg/ml
PURITY DETAIL:	Protein G-affinity purified.
FORMULATION:	Liquid. In PBS, pH 7.2, containing 0.01% sodium azide.
IMMUNOGEN:	CEACAM5 (CEA) partially purified from a perchloric acid extract from liver metastases of colonic tumors.
SPECIFICITY:	Recognizes human CEACAM1, 5, 6 and 8.
APPLICATION:	ELISA Flow Cytometry Immunohistochemistry (frozen sections) Western Blot. Optimal conditions must be determined individually for each application.
QUALITY CONTROL:	Routinely tested by flow cytometry on BOSC23 cells transiently transfected with a CEACAM5 expression vector.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.

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Product Specific Literature References

Two CEA and three NCA species, although distinguishable by monoclonal antibodies, have nearly identical peptide patterns: F. Grunert, et al.; Int. J. Cancer 36, 357 (1985) Abstract
CD66 family Workshop: Binding of myeloid blind panel antibodies and CD66 Subsection antibodies to HeLa transfectants expressing individual CD66 molecules: F. Grunert, et al.; Leukocyte Typing VI: White cell Differentiation Antigens (T. Kishimoto, et al., eds.), Garland Publishing Inc., New York 1012 (1996)
Homophilic adhesion of human CEACAM1 involves N-terminal domain interactions: structural analysis of the binding site: S.M. Watt, et al.; Blood 98, 1469 (2001) Abstract; Full Text

General Information

CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family. It consists of seven CEACAM (CEACAM1, CEACAM3-CEACAM8) and 11 pregnancy-specific glycoprotein (PSG1-PSG11) members. The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leukocytes. Overexpression of CEA/CEACAM5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. The function of CEACAM family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocytes and dendritic cell activation, receptors of Neisseria species and other bacteria.

MANUFACTURER

Manufactured by GENOVAC GmbH.

General Literature References

Carcinoembryonic antigen gene family: molecular biology and clinical perspectives: J.A. Thompson, et al.; J. Clin. Lab. Anal. 5, 344 (1991), (Review) Abstract
The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues: S. Hammarström; Semin. Cancer Biol. 9, 67 (1999), (Review) Abstract
Carcinoembryonic antigen: W. Zimmermann; Wiley Encylopedia of Molecular Medicine (T. Creighton, ed.), John Wiley & Sons Inc., New York 459 (2002)

Further Categories Containing This Product:

CD Antibodies • Monoclonal Antibodies

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