ALEXIS Biochemicals: Monoclonal Antibody to MRP2 (human) (M2I-4)

ALX-801-015

Revised 24-Feb-06

Monoclonal Antibody to MRP2 (human) (M2I-4)
SYNONYMS	anti-Multidrug Resistance-associated Protein 2 (human) MAb (M₂I-4) anti-cMOAT (human) MAb (M₂I-4) anti-ABCC2 (human) MAb (M₂I-4)
PRODUCT LINE	Cancer
PRODUCT CATEGORY	MDR-associated Proteins [MRPs] / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-801-015-C250		250 µg	630.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	M₂I-4
ISOTYPE:	Mouse IgG1
CONCENTRATION:	~250µg/ml.
FORMULATION:	Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide.
IMMUNOGEN:	Recombinant human MRP2 (multidrug resistance-associated protein 2; cMOAT) (aa 215-310).
SPECIFICITY:	Recognizes an internal epitope of human MRP2. Does not cross-react with human P-glycoprotein, MDR3 P-glycoprotein, MRP1, MRP3 or MRP5. Does not cross-react with mouse, rat or guinea pig MRP2.
APPLICATION:	Immunocytochemistry: Use 1:20-1:50 dilution on acetone fixed cytospin preparations. Immunohistochemistry: Frozen sections: Use 1:20 dilution on acetone fixed frozen sections followed by incubation with rabbit anti-mouse IgG and a monoclonal mouse APAAP complex. Or, after incubation with the primary antibody and washing, slides can be incubated with biotinylated rabbit anti-mouse IgG and streptavidin conjugated to horseradish peroxidase. Paraffin sections: Weak reactivity. Western Blot: Use 1:20-1:50 dilution and anti-mouse-HRP.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C

Product Specific Literature References

Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies: G.L. Scheffer, et al.; Cancer Res. 60, 5269 (2000) Abstract; Full Text

General Literature References

Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene: C.C. Paulusma, et al.; Science 271, 1126 (1996) Abstract
Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines: M. Kool, et al.; Cancer Res. 57, 3537 (1997) Abstract

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Monoclonal Antibodies

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