ALEXIS Biochemicals: Monoclonal Antibody to RELM-β (human) (HRB 46D)

ALX-804-522

Revised 18-Oct-06

Monoclonal Antibody to RELM-β (human) (HRB 46D)
SYNONYMS	anti-Resistin-like Molecule-β (human) MAb (HRB 46D) anti-FIZZ2 (human) MAb (HRB 46D) anti-HXCP2 (human) MAb (HRB 46D)
PRODUCT LINE	Obesity & Adipokines
PRODUCT CATEGORY	Resistin & Resistin-like Molecules [RELMs] / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-522-C050		50 µg	195.00 USD
ALX-804-522-C100		100 µg	270.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	HRB 46D.
ISOTYPE:	Mouse IgG2b.
CONCENTRATION:	1mg/ml.
FORMULATION:	Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:	Recombinant human RELM-β (resistin-like molecule-β).
SPECIFICITY:	Recognizes human RELM-β. Does not cross-react with mouse RELM-β.
APPLICATION:	ELISA (direct and indirect: 1:5'000-1:10'000) Western Blot (1:2'000-1:10'000 using ECL. Suggested blocking and dilution buffer is TBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature). Optimal conditions must be determined individually for each application.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.

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General Information

RELM-β (resistin-like molecule-β; FIZZ2) is a 19 kDa disulfide-linked homodimeric protein expressed in the epithelium of the colon and small bowel. The biological functions of RELM-β, and its molecular targets, are not fully known, but it has been suggested that it plays a regulatory role during inflammation and may also act to establish links among adipose tissue, the intestine and the liver [1]. Interestingly, the molecular structure of RELM-β is highly homologous to that of the adipose-derived cytokine resistin.

MANUFACTURER

Manufactured by AdipoGen, Inc.

General Literature References

[1] Adipose-derived resistin and gut-derived resistin-like molecule-beta selectively impair insulin action on glucose production : M.W. Rajala, et al. ; J. Clin. Invest. 111, 225 (2003) Abstract; Full Text

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Monoclonal Antibodies

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