ALEXIS Biochemicals: Monoclonal Antibody to Toll-like Receptor 4/MD-2 (mouse) (MTS510)

ALX-804-430

Revised 24-Apr-07

Monoclonal Antibody to Toll-like Receptor 4/MD-2 (mouse) (MTS510)
SYNONYMS	anti-TLR4/MD-2 (mouse) MAb (MTS510)
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	TLR Antibodies

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-430PF-C100	Preservative Free	100 µg	270.00 USD
ALX-804-430-C100	Purified	100 µg	270.00 USD
ALX-804-430F-T100	FITC	100 tests	300.00 USD
ALX-804-430TD-T100	ATTO 488	100 tests	340.00 USD
ALX-804-430TS-T100	ATTO 647N	100 tests	340.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Mouse
CLONE:	MTS510
ISOTYPE:	Rat IgG2a
CONCENTRATION:	1mg/ml
PURITY:	≥95% (SDS-PAGE)
FORMULATION:	Liquid. In PBS containing 0.02% sodium azide. MTS510 (Preservative Free): Liquid. In PBS.
IMMUNOGEN:	Ba/F3 cells expressing mouse TLR4 and MD-2 complex.
SPECIFICITY:	Recognizes the mouse TLR4/MD-2 complex.
APPLICATION:	MTS510 & MTS510 (Preservative Free): Flow Cytometry Immunoprecipitation Functional Application (inhibition of LPS-induced cytokine production; use preservative free formulation). MTS510-ATTO 488: Flow Cytometry MTS510-ATTO 647N: Flow Cytometry MTS510-FITC: Flow Cytometry
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored as recommended.
HANDLING:	For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep ATTO, Biotin- and FITC-conjugated formats at +4°C. Do not freeze. Protect from light.

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Product Specific Literature References

Cutting edge: cell surface expression and lipopolysaccharide signaling via the toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages: S. Akashi, et al.; J. Immunol. 164, 3471 (2000) Abstract; Full Text
Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression: F. Nomura, et al.; J. Immunol. 164, 3476 (2000) Abstract; Full Text
Synergy and cross-tolerance between toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways: S. Sato, et al.; J. Immunol. 165, 7096 (2000) Abstract; Full Text
The role of TLR2 in the inflammatory activation of mouse fibroblasts by human antiphospholipid antibodies: N. Satta, et al.; Blood 109, 1507 (2007) Abstract

General Information

BACKGROUND/TECHNICAL INFORMATION	MTS510-FITC: 1 test means: 1µl of a 0.1mg/ml stock solution were used to stain 200’000 cells in a sample volume of 50µl.
MANUFACTURER	Manufactured by Apotech Corporation.

Further Categories Containing This Product:

TLR Co-Receptors Other Products • CD Antibodies • Monoclonal Antibodies

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