• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Toolbar - View Selection
 
Items 1 of 1
ALX-350-288 Revised 21-May-08
Mycalolide B
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cytoskeletal Research
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-288-C100   100 µg 590.00 USD Add To Cart
Product Specification
FORMULA: C52H74N4O17
MW: 1027.2
CAS NUMBER: 122752-21-0
SOURCE/HOST: Isolated from the marine sponge Mycale sp.
PURITY: ≥98%
APPEARANCE: Clear to white solid.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Keep under inert gas.
HAZARD: TOXIC.

Product Description
Inhibits actin polymerization (IC50=10-50nM) with a different mechanism of action from cytochalasin D (Prod. No. ALX-380-031). Suppresses actin-activated myosin Mg2+-ATPase activity. Depolymerizes F-actin by nibbling and forms a 1:1 complex with G-actin.
Product Specific Literature References
Mycalolide-B, a novel and specific inhibitor of actomyosin ATPase isolated from marine sponge: M. Hori, et al.; FEBS Lett. 322, 151 (1993) Abstract
Mycalolide B, a novel actin depolymerizing agent: S. Saito, et al.; J. Biol. Chem. 269, 29710 (1994) Abstract; Full Text
Cellular changes of rat embryonic fibroblasts by an actin-polymerization inhibitor, bistheonellide A, from a marine sponge: S. Watabe, et al.; Cell Struct. Funct. 21, 199 (1996) Abstract
Inhibition of rat platelet aggregation by mycalolide-B, a novel inhibitor of actin polymerization with a different mechanism of action from cytochalasin-D: A. Sugidachi, et al.; Thromb. Haemost. 79, 614 (1998) Abstract
Actin-binding specificity of marine macrolide toxins, mycalolide B and kabiramide D: S. Wada, et al.; J. Biochem. (Tokyo) 123, 946 (1998) Abstract; Full Text
Uncoupling of gate and fence functions of MDCK cells by the actin-depolymerizing reagent mycalolide B: R. Takakuwa, et al.; Exp. Cell Res. 257, 238 (2000) Abstract
Actin filaments play an essential role for transport of nascent HIV-1 proteins in host cells: H. Sasaki, et al.; BBRC 316, 588 (2004) Abstract
Further Categories Containing This Product:
Natural Products - ATPase Inhibitors • Actin/Related Products
 
 
© 2008 ALEXIS Corporation, Privacy Policy, Disclaimer, Feedbackanother CS2 website

Catalogs / Brochures

E-Newsletter

 

Shopping Cart [0]

 

Distributors

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.