ALEXIS Biochemicals: Myelin Basic Protein (human) (high purity)

ALX-200-606

Revised 08-May-08

Myelin Basic Protein (human) (high purity)
SYNONYMS	MBP (human) (high purity)
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	Myelin Basic Protein / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-200-606-M001		1 mg	350.00 USD

Product Specification

SOURCE/HOST:	Purified from human brain by method of Määttä et al. [1].
CONCENTRATION:	1mg/ml after reconstitution.
PURITY:	≥95% (SDS-PAGE; Immunoblot)
APPEARANCE:	White to off-white powder.
FORMULATION:	Lyophilized. Essentially salt-free.
RECONSTITUTION:	Reconstitute with distilled water.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 1 year when stored at +4°C. Reconstituted protein is stable for at least six months at -20°C and for at least 24 hours at +37°C in aqueous solution.

Product Specific Literature References

[1] Detection of myelin basic protein isoforms by organic concentration: J.A. Määttä, et al.; BBRC 238, 498 (1997) Abstract
Interaction between the C-terminal region of human myelin basic protein and calmodulin: analysis of complex formation and solution structure: V. Majava, et al.; BMC Struct. Biol. 8, 10 (2008) Abstract; Full Text

General Information

MBP is a peripheral membrane protein, and its interaction with lipids is generally believed to be critical for the formation and stability of the multilamellar myelin sheath. It has been identified as a Ca²⁺-calmodulin regulated agent for actin polymerization, tropomyosin and actomyosin function, tubulin stabilization, and clathrin assembley. MBP is generally considered to be the antigen responsible for autoimmunity in multiple sclerosis (MS) and it has the capability to induce experimental allergic encephalomyelitis (EAE). MBP is also an endogenous inhibitor of the high-affinity cannabinoid binding site in the brain and a substrate for numerous protein kinases (MAPK, serine/threonine kinase, protein kinase C). MBP is also suggested to be involved in intracellular signalling and as cytoskeletal components.

Further Categories Containing This Product:

MAPK Pathway Substrates • CAM Kinase Substrates • Natural Proteins

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