ALEXIS Biochemicals: Myelin Basic Protein (porcine) (high purity)

ALX-202-077

Revised 22-Aug-06

Myelin Basic Protein (porcine) (high purity)
SYNONYMS	MBP (porcine) (high purity)
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	Myelin Basic Protein/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-202-077-M001		1 mg	35.00 USD
ALX-202-077-M005		5 mg	140.00 USD

Product Specification

SOURCE/HOST:	Purified from porcine brain by method of Määttä et al. [1].
PURITY:	≥95% (SDS-PAGE; immunoblot)
FORMULATION:	Lyophilized. Essentially salt-free.
RECONSTITUTION:	Reconstitute with distilled water.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 3 years when stored at +4°C. Reconstituted protein is stable for at least six months at -20°C and for at least 24 hours at +37°C in aqueous solution.

Product Description

Passes activity test as a protein kinase substrate according to Courtney et al. [2].

Product Specific Literature References

[1] Detection of myelin basic protein isoforms by organic concentration: J.A. Määttä, et al.; BBRC 238, 498 (1997) Abstract
[2] Neurotrophins protect cultured cerebellar granule neurons against the early phase of cell death by a two-component mechanism: M.J. Courtney, et al.; J. Neurosci. 17, 4201 (1997) Abstract

General Information

MBP is a peripheral membrane protein, and its interaction with lipids is generally believed to be critical for the formation and stability of the multilamellar myelin sheath. It has been identified as a Ca²⁺-calmodulin regulated agent for actin polymerization, tropomyosin and actomyosin function, tubulin stabilization, and clathrin assembley.
MBP is generally considered to be the antigen responsible for autoimmunity in multiple sclerosis (MS) and it has the capability to induce experimental allergic encephalomyelitis (EAE). MBP is also an endogenous inhibitor of the high-affinity cannabinoid binding site in the brain and a substrate for numerous protein kinases (MAPK, serine/threonine kinase, protein kinase C). MBP is also suggested to be involved in intracellular signalling and as cytoskeletal components.

Further Categories Containing This Product:

CAM Kinase Substrates • MAPK Pathway Substrates • Natural Proteins

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