ALEXIS Biochemicals: N-Oxalyl-D-alanine

ALX-270-414

Revised 06-Jul-06

N-Oxalyl-D-alanine
SYNONYMS	NODA N-Oxalyl-2R-alanine NOxRA
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Hypoxia-inducible Factor [HIF]/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-414-M010		10 mg	80.00 USD
ALX-270-414-M050		50 mg	240.00 USD

Product Specification

FORMULA:	C₅H₇NO₅ . H₂O
MW:	161.1 . 18.0
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Very hygroscopic.

Product Description

Cell permeable, potent competitive inhibitor of factor inhibiting HIF asparagine hydroxylase (FIH, IC₅₀<0.4mM). Does not inhibit PHDs (prolyl hydroxylase domain-containing proteins; HIF-PHs).

Product Specific Literature References

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation: P. Jaakkola, et al.; Science 292, 468 (2001) Abstract
Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha: J.M. Elkins, et al.; J. Biol. Chem. 278, 1802 (2003) Abstract

another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.