ALEXIS Biochemicals: N2,2'-O-Dibutyrylguanosine 3',5'-cyclic Monophosphate . sodium salt

ALX-480-046

Revised 03-Mar-05

N2,2'-O-Dibutyrylguanosine 3',5'-cyclic Monophosphate . sodium salt
SYNONYMS	Dibutyryl-cGMP . Na DBcGMP . Na
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	cGMP Derivatives

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-480-046-M005		5 mg	40.00 USD
ALX-480-046-M025		25 mg	160.00 USD

Product Specification

FORMULA:	C₁₈H₂₃N₅O₉P . Na
MW:	484.4 . 23.0
CAS NUMBER:	51116-00-8
PURITY:	≥95%
APPEARANCE:	White solid.
SOLUBILITY:	Soluble in ethanol or water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Activates cGMP-dependent protein kinase (PKG). Cell permeable. For a better and more selective agonist, use 8-pCPT-cGMP (Prod. No. ALX-480-031 or Prod. No. ALX-480-088).

Product Specific Literature References

Analogs of cyclic AMP and cyclic GMP: general methods of synthesis and the relationship of structure to enzymic activity: R.B. Meyer & J.P. Miller; Life Sci. 14, 1019 (1974) Abstract
Relaxation of hormonally stimulated smooth muscular tissues by the 8- bromo derivative of cyclic GMP: K.D. Schultz, et al.; Naunyn-Schmiedeberg's Arch. Pharmacol. 306, 1 (1979) Abstract
Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase: S.G. Francis, et al.; Mol. Pharmacol. 34, 506 (1988) Abstract
Cyclic GMP analogs inhibit gamma thrombin-induced arachidonic acid release in human platelets: D.C. Sane, et al.; BBRC 165, 708 (1989) Abstract
Analysis of the functional role of cGMP-dependent protein kinase in intact human platelets using a specific activator 8-para-chlorophenylthio-cGMP: E. Butt, et al.; Biochem. Pharmacol. 43, 2591 (1992) Abstract

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