ALEXIS Biochemicals: NCO-700 . hemisulfate

ALX-270-103

Revised 28-Jan-05

NCO-700 . hemisulfate
SYNONYMS	Calpain Inhibitor
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Calpains / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-103-M001		1 mg	75.00 USD
ALX-270-103-M005		5 mg	300.00 USD

Product Specification

FORMULA:	(C₂₆H₃₉N₃O₈)₂ . H₂SO₄
MW:	1141.3 . 98.0
PURITY:	≥98%
APPEARANCE:	White crystalline solid.
SOLUBILITY:	Soluble in 100% ethanol or water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light.
HAZARD:	TOXIC.

Product Description

Specific thiol (cysteine) protease inhibitor. Active against calpains, cathepsin B and L and papain. Inhibits fMLP-stimulated PMN oxidant production; scavenges reactive oxygen species.

Product Specific Literature References

K. Hara & K. Takahashi; Biomed. Res. 4, 121 (1983)
Purification and characterization of cathepsin B from monkey skeletal muscle: T. Hirao, et al.; J. Biochem. 95, 871 (1984) Abstract
Ca overload and the action of calcium sensitive proteases, phospholipases and prostaglandin E2 in myocardial cell degradation: T. Toyo-oka, et al.; Basic Res. Cardiol. 80, 303 (1985) Abstract
Suppression of myocardial protein degradation by the protease inhibitor bis[ethyl(2R,3R)-3-[(S)-methyl-1-[4-(2,3,4-tri-methoxy-phenyl-methyl) piperazine-1-ylcarbonyl]butyl-carbonyl]oxiran-2-carboxylat e]sulfate under hypoxia: T. Toyo-oka, et al.; Drug Res. 36, 190 (1986) Abstract
Effect of NCO-700, an inhibitor of thiol protease, on reactive oxygen production by chemotactic peptide-stimulated rabbit peripheral granulocytes: K. Tawara, et al.; Experientia 44, 346 (1988) Abstract
A protease inhibitor, NCO-700, improves the contractile function in stunned canine myocardium: H. Ikeda, et al.; Jpn. Cir. J. 58, 713 (1994) Abstract

Further Categories Containing This Product:

Cathepsin Inhibitors • Proteases Other Products

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