ALEXIS Biochemicals: NG-Amino-L-arginine . hydrochloride

ALX-106-014

Revised 12-Sep-06

NG-Amino-L-arginine . hydrochloride
SYNONYMS	L-NAA . HCl
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	NOS Inhibitors (NOS Induction & Enzyme Activity)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-106-014-M005		5 mg	50.00 USD

Product Specification

FORMULA:	C₆H₁₅N₅O₂. HCl
MW:	189.2 . 36.5
PURITY:	≥97% (contains traces of L-ornithine and L-arginine)
APPEARANCE:	White powder.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C

Product Description

Potent inhibitor of endothelial and inducible nitric oxide synthase (eNOS/NOS III and iNOS/NOS II).

Product Specific Literature References

NG-amino-L-arginine: a new potent antagonist of L-arginine-mediated endothelium-dependent relaxation: J.M. Fukuto, et al.; BBRC 168, 458 (1990) Abstract
Macrophage and endothelial cell nitric oxide synthesis: cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG- methylarginine: S.S. Gross, et al.; BBRC 170, 96 (1990) Abstract
Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle: L.J. Ignarro, et al.; BBRC 170, 843 (1990) Abstract
Nitric oxide synthesis in the CNS endothelium and macrophages differs in its sensitivity to inhibition by arginine analogues: L. Lambert, et al.; Life Sci. 48, 69 (1991) Abstract
Comparison of the inhibitory potencies of N(G)-methyl-, N(G)-nitro- and N(G)-amino-L-arginine on EDRF function in the rat: evidence for continuous basal EDRF release: H.M. Vargas, et al.; J. Pharmacol. Exp. Ther. 257, 1208 (1991) Abstract
Inhibition of purified nitric oxide synthase from rat cerebellum and macrophage by L-arginine analogs: Y. Komori, et al.; Arch. Biochem. Biophys. 315, 213 (1994) Abstract
Inactivation of nitric oxide synthase isoforms by diaminoguanidine and NG-amino-L-arginine: D.J. Wolff & A. Lubeskie; Arch. Biochem. Biophys. 325, 227 (1996) Abstract
Studies of neuronal nitric oxide synthase inactivation by diverse suicide inhibitors: R. Bryk, et al.; Arch. Biochem. Biophys. 369, 243 (1999) Abstract
Alteration of the heme prosthetic group of neuronal nitric-oxide synthase during inactivation by N(G)-amino-L-arginine in vitro and in vivo: J.L. Vuletich, et al.; Mol. Pharmacol. 62, 110 (2002) Abstract; Full Text
Metabolism of aminoguanidine, diaminoguanidine, and NG-amino-L-arginine by neuronal NO-synthase and covalent alteration of the heme prosthetic group: A.J. Lee, et al.; Chem. Res. Toxicol. 18, 1927 (2005) Abstract

another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.