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ALX-380-091
Revised 03-Apr-08
17-AAG
SYNONYMS
17-(Allylamino)-17-desmethoxygeldanamycin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antitumor Antibiotics
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Product Numbers:
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ALX-380-091-M001
1 mg
162.00 USD
ALX-380-091-C100
100 µg
65.00 USD
Product Specification
FORMULA:
C
31
H
43
N
3
O
8
MW:
585.7
CAS NUMBER:
75747-14-7
SOURCE/HOST:
Semisynthetic derivative from geldanamycin.
PURITY:
≥97%
APPEARANCE:
Red to dark red powder.
SOLUBILITY:
Soluble in DMSO (10mg/ml) or methanol (10mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Potent, less toxic derivative of geldanamycin (Prod. No.
ALX-380-054
). Inhibits the essential ATPase activity of HSP90. Inhibitor of telomerase activity. Inducer of apoptosis with antitumor activity.
Product Specific Literature References
Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives:
R.C. Schnur, et al.; J. Med. Chem.
38
, 3806 (1995)
Abstract
The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin:
T.W. Schulte & L.M. Neckers; Cancer Chemother. Pharmacol.
42
, 273 (1998)
Abstract
Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone:
P.A. Clarke, et al.; Oncogene
19
, 4125 (2000)
Abstract
Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin lowers Bcr-Abl levels and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic blasts:
R. Nimmanapalli, et al.; Cancer Res.
61
, 1799 (2001)
Abstract
;
Full Text
Inhibition of heat shock protein 90 function by ansamycins causes the morphological and functional differentiation of breast cancer cells:
P.N. Munster, et al.; Cancer Res.
61
, 2945 (2001)
Abstract
;
Full Text
Disruption of the EF-2 kinase/Hsp90 protein complex: a possible mechanism to inhibit glioblastoma by geldanamycin:
J. Yang, et al.; Cancer Res.
61
, 4010 (2001)
Abstract
;
Full Text
Enhancement of paclitaxel-mediated cytotoxicity in lung cancer cells by 17-allylamino geldanamycin: in vitro and in vivo analysis:
D.M. Nguyen, et al.; Ann. Thorac. Surg.
72
, 371 (2001)
Abstract
ErbB2 degradation mediated by the co-chaperone protein CHIP:
P. Zhou, et al.; J. Biol. Chem.
278
, 13829 (2003)
Abstract
Inhibition of telomerase activity by geldanamycin and 17-allylamino, 17-demethoxygeldanamycin in human melanoma cells:
R. Villa, et al.; Carcinogenesis
24
, 851 (2003)
Abstract
Geldanamycin and its 17-allylamino-17-demethoxy analogue antagonize the action of Cisplatin in human colon adenocarcinoma cells: differential caspase activation as a basis for interaction:
I.A. Vasilevskaya, et al.; Cancer Res.
63
, 3241 (2003)
Abstract
A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors:
A. Kamal, et al.; Nature
425
, 407 (2003)
Abstract
Chaperoning oncogenes: HSP90 as a target of geldanamycin:
L. Neckers; Handb. Exp. Pharmacol. 259 (2006)
Abstract
Drugging the cancer chaperone HSP90: Combinatorial therapeutic exploitation of oncogene addiction and tumor stress:
P. Workman, et al.; Ann. N.Y. Acad. Sci.
1113
, 202 (2007)
Abstract
Synergism between etoposide and 17-AAG in leukemia cells: critical roles for Hsp90, FLT3, topoisomerase II, Chk1, and Rad51:
Q. Yao, et al.; Clin. Cancer Res.
13
, 1591 (2007)
Abstract
;
Full Text
Phase I and pharmacodynamic study of 17-(allylamino)-17-demethoxygeldanamycin in adult patients with refractory advanced cancers:
R.K. Ramanathan, et al.; Clin. Cancer Res.
13
, 1769 (2007)
Abstract
HSP90 inhibitor 17AAG causes apoptosis in ATRA-resistant acute promyelocytic leukemia cells:
P.N. Meyer, et al.; Leuk. Res.
32
, 143 (2008)
Abstract
Intratumor injection of the Hsp90 inhibitor 17AAG decreases tumor growth and induces apoptosis in a prostate cancer xenograft model:
C.R. Williams, et al.; J. Urol.
178
, 1528 (2007)
Abstract
Rituximab and 17-allylamino-17-demethoxygeldanamycin induce synergistic apoptosis in B-cell chronic lymphocytic leukaemia:
A.J. Johnson, et al.; Br. J. Haematol.
139
, 837 (2007)
Abstract
An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models:
U. Banerji, et al.; Cancer Chemother. Pharmacol.
Epub ahead of print
, (2008)
Abstract
Further Categories Containing This Product:
Antibiotics - Apoptosis Inducers & Inhibitors
•
Antitumor Agents (Enzyme Inhibitors)
•
Tyrosine Kinase Inhibitors
•
Antibiotics - Other Signal Transduction Pathway Modulators
•
HSP90/HtpG/Related Products
ALX-450-001
Revised 23-Jul-08
A23187 (free acid)
SYNONYMS
Calcium Ionophore A23187
Calcimycin
Antibiotic A23187
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Ionophores
Ordering Information
Product Numbers:
Format:
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Unit Price:
Quantity:
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ALX-450-001-M001
1 mg
28.00 USD
ALX-450-001-M005
5 mg
65.00 USD
ALX-450-001-M010
10 mg
92.00 USD
ALX-450-001-M025
25 mg
195.00 USD
ALX-450-001-M050
50 mg
350.00 USD
ALX-450-001-5001
5x1 mg
80.00 USD
Product Specification
FORMULA:
C
29
H
37
N
3
O
6
MW:
523.6
CAS NUMBER:
52665-69-7
MERCK INDEX:
14:
1639
RTECS:
DM4676000
SOURCE/HOST:
Isolated from
Streptomyces chartreusis
.
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO, 100% ethanol or methylene chloride; slightly soluble in water. Solubilize in DMSO or ethanol prior to preparing aqueous solutions of very low concentrations.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
In aqueous systems product may aggregate over time.
HANDLING:
Protect from light. In aqueous systems, the product aggregates over time.
HAZARD:
IRRITANT.
Product Description
Antibiotic possessing weak
in vitro
antimicrobial activity against gram positive bacteria and fungi. Divalent cation ionophore commonly used to increase intracellular Ca
2+
levels in intact cells.
Product Specific Literature References
A23187: a divalent cation ionophore:
P. W. Reed & H. A. Lardy; J. Biol. Chem.
247
, 6970 (1972)
Abstract
Effects of antibiotic ionophore, A23187, on oxidative phosphorylation and calcium transport of liver mitochondria:
D.T. Wong, et al.; Arch. Biochem. Biophys.
156
, 578 (1973)
Abstract
Biological applications of ionophores:
B.C. Pressman; Annu. Rev. Biochem.
45
, 501 (1976), (Review)
Abstract
Molecular mechanisms of endothelium-mediated vasodilation:
R.R. Fiscus; Semin. Thromb. Hemost.
14 Suppl
, 12 (1988), (Review)
Abstract
Calcium ionophore A23187 action on cardiac myocytes is accompanied by enhanced production of reactive oxygen species: 1740, 481 (2005):
T. Przygodzki, et al.; Biochim. Biophys. Acta
1740
, 481 (2005)
Abstract
Further Categories Containing This Product:
Nitric Oxide Pathway Other Products
•
Respiratory Chain Other Products
•
Antibiotics - ATPase Inhibitors
ALX-450-002
Revised 14-Nov-07
A23187 (Mixed Calcium-Magnesium Salt)
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Ionophores
Ordering Information
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Format:
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ALX-450-002-M005
5 mg
60.00 USD
ALX-450-002-M010
10 mg
110.00 USD
ALX-450-002-M050
50 mg
415.00 USD
Product Specification
MERCK INDEX:
13:
1639
SOURCE/HOST:
Semisynthetic.
PURITY:
≥98% (molar ratio Ca:Mg ~1:1)
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in methylene chloride, chloroform, acetone, ethyl acetate, or diethyl ketone; also soluble in DMSO, 100% ethanol, and ethanol. Solubilize in DMSO or ethanol prior to preparing aqueous solutions of very low concentrations.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light. In aqueous systems, product may aggregate over time.
HAZARD:
TOXIC.
Product Description
Salt form of A23187 (Prod. No.
ALX-450-001
). Used in cell activation experiments when calcium dose-response data are not required.
ALX-350-104
Revised 10-May-07
Aaptamine
SYNONYMS
8,9-Dimethoxy-1
H
-benzo[
de
][1,6]naphtyridine
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Toxins
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ALX-350-104-M001
1 mg
90.00 USD
Product Specification
FORMULA:
C
13
H
12
N
2
O
2
MW:
228.3
CAS NUMBER:
85547-22-4
SOURCE/HOST:
Isolated from the sponge
Aaptos aaptos
.
PURITY:
≥97%
APPEARANCE:
Oil.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
Product Description
Competitive antagonist of α-adrenoceptors in vascular smooth muscle cells. Inhibits cancer cell growth.
Product Specific Literature References
Alpha-adrenoceptor blocking action of aaptamine, a novel marine natural product, in vascular smooth muscle
:
Y. Ohizumi, et al.; J. Pharm. Pharmacol.
36
, 785 (1984)
Abstract
Antineoplastic agents 491. Synthetic conversion of aaptamine to isoaaptamine, 9-demethylaaptamine, and 4-methylaaptamine:
G.R. Pettit, et al.; J. Org. Chem.
69
, 2251 (2004)
Abstract
Aaptamine, a spongean alkaloid, activates p21 promoter in a p53-independent manner:
S. Aoki, et al.; BBRC
342
, 101 (2006)
Abstract
Further Categories Containing This Product:
Alkaloids
•
Antitumor Agents (Anti-proliferative)
•
Adrenergics & Adrenergic Receptors/Related Products
•
Natural Products - Antitumor Reagents
ALX-350-255
Revised 03-Apr-08
(+)-cis,trans-Abscisic acid
SYNONYMS
(S)-5-(1-Hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl)-3-methyl-[2Z,4E]-pentadienoic acid
(+)-
cis
,
trans
ABA
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Plant Research Reagents
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ALX-350-255-M001
1 mg
160.00 USD
ALX-350-255-M005
5 mg
620.00 USD
ALX-350-255-C500
500 µg
90.00 USD
Product Specification
FORMULA:
C
15
H
20
O
4
MW:
264.3
CAS NUMBER:
21293-29-8
MERCK INDEX:
14:
11
SOURCE/HOST:
Isolated from
Curvularia lunata
.
PURITY:
≥97%
APPEARANCE:
Off-white powder.
SOLUBILITY:
Soluble in ethanol or DMSO.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Natural and active isomer of the abscission accelerating plant hormone.
Product Specific Literature References
Metabolism and physiology of abscisic acid:
J.A.D. Zeevaart & R.A. Creelman; Annu. Rev. Plant Physiol. Plant Mol. Biol.
39
, 439 (1988), (Review)
Molecular responses to drought and cold stress:
K. Shinozaki & K. Yamaguchi-Shinozaki; Curr. Opin. Biotechnol.
7
, 161 (1996), (Review)
Abstract
Abscisic acid and signal transduction:
J. Leung & J. Giraudat; Annu. Rev. Plant Physiol. Plant Mol. Biol.
49
, 199 (1998), (Review)
ABA signal transduction:
E. Grill & A. Himmelbach; Curr. Opin. Plant Biol.
1
, 412 (1998), (Review)
Abstract
Signal transduction networks and the biology of plant cells:
M.J. Chrispeels, et al.; Biol. Res.
32
, 35 (1999), (Review)
Abstract
Abscisic acid:
A.M. Hetherington; Curr. Biol.
9
, R390 (1999), (Review)
Abstract
Regulation of abscisic acid-induced stomatal closure and anion channels by guard cell AAPK kinase
:
J. Li, et al.; Science
287
, 300 (2000)
Abstract
Mitogen-activated protein kinase and abscisic acid signal transduction:
S. Heimovaara-Dijkstra, et al.; Results Probl. Cell Differ.
27
, 131 (2000)
Abstract
Relay and control of abscisic acid signaling:
A. Himmelbach, et al.; Corr. Opin. Plant Biol.
6
, 470 (2003), Review
Abstract
Nitric oxide induced by hydrogen peroxide mediates abscisic acid-induced activation of the mitogen-activated protein kinase cascade involved in antioxidant defense in maize leaves:
A. Zhang, et al.; New Phytol.
175
, 36 (2007)
Abstract
Abscisic acid is an endogenous cytokine in human granulocytes with cyclic ADP-ribose as second messenger:
S. Bruzzone, et al.; PNAS
104
, 5759 (2007)
Abstract
Further Categories Containing This Product:
Natural Products - Nitric Oxide Pathway Modulators
•
Plant Research Reagents/Related Products
ALX-350-310
Revised 03-Apr-08
3-O-Acetyl-11-keto-β-boswellic acid
SYNONYMS
AKβBA
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Antitumor Reagents
Ordering Information
Product Numbers:
Format:
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ALX-350-310-M005
5 mg
130.00 USD
Product Specification
FORMULA:
C
32
H
48
O
5
MW:
512.7
CAS NUMBER:
67416-61-9
SOURCE/HOST:
Isolated from
Boswellia serrata.
PURITY:
≥99% (HPLC, NMR)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in acetone, dichloromethane, diethyl ether or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING:
Protect from light.
HAZARD:
MAY BE CARCINOGENIC. HARMFUL.
Product Description
Shows antitumor and anti-inflammatory activities. Potent non-redox, noncompetitive 5-lipoxygenase and topoisomerase I and IIa inhibitor leading to apoptosis. 10-times more potent than 3-O-acetyl-β-boswellic acid (Prod. No.
ALX-350-308
). Exhibits
in vivo
efficacy in tumor growth and inhibition.
Product Specific Literature References
Acetyl-11-keto-beta-boswellic acid induces apoptosis in HL-60 and CCRF-CEM cells and inhibits topoisomerase I:
R.F. Hoernlein, et al.; J. Pharmacol. Exp. Ther.
288
, 613 (1999)
Abstract
;
Full Text
Boswellic acids activate p42(MAPK) and p38 MAPK and stimulate Ca(2+) mobilization:
A. Altmann, et al.; BBRC
290
, 185 (2002)
Abstract
Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes:
A. Altmann, et al.; Br. J. Pharmacol.
141
, 223 (2004)
Abstract
;
Full Text
Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo:
T. Syrovets, et al.; J. Biol. Chem.
280
, 6170 (2005)
Abstract
;
Full Text
Boswellic acids: biological actions and molecular targets:
D. Poeckel & O. Werz; Curr. Med. Chem.
13
, 3359 (2006), Review
Abstract
Mechanisms underlying the anti-inflammatory actions of boswellic acid derivatives in experimental colitis:
C. Anthoni, et al.; Am. J. Physiol. Gastrointest. Liver Physiol.
290
, G1131 (2006)
Abstract
Potentiation of antinociceptive effect of NSAIDs by a specific lipooxygenase inhibitor, acetyl 11-keto-beta boswellic acid:
M. Bishnoi, et al.; Indian J. Exp. Biol.
44
, 128 (2006)
Abstract
Related Products
ALX-350-308
3-O-Acetyl-β-boswellic acid
Further Categories Containing This Product:
Natural Products - NF-kB Pathway Inhibitors
•
Antitumor Agents (Apoptosis Inducers)
•
Natural Products - Protein Kinase Inhibitors
•
Natural Products - Topoisomerase Inhibitors
•
Natural Products - Anti-inflammatory Agents
•
NF-kB Pathway Inhibitors
•
Natural Products - Apoptosis Inducers & Inhibitors
•
Lipoxygenases/Related Products
ALX-550-232
Revised 13-May-08
Aconitine
SYNONYMS
(1α,3α,6α,14α,15α,16β)-20-Ethyl-1,6,16-trimethoxy-4-(methoxymethyl)aconitane-3,8,13,14,15-pentol 8-acetate 14-benzoate
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Neurotoxins
Ordering Information
Product Numbers:
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Unit Price:
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ALX-550-232-M025
25 mg
45.00 USD
Product Specification
FORMULA:
C
34
H
47
NO
11
MW:
645.7
CAS NUMBER:
302-27-2
MERCK INDEX:
14:
118
RTECS:
AR5960000
SOURCE/HOST:
Isolated from
Aconitum karacolium
.
PURITY:
≥98%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in 100% ethanol (35mg/ml); almost insoluble in water (0.3mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
HAZARD:
VERY TOXIC.
Product Description
A lipid-soluble neurotoxin that acts as a sodium channel modulator. Blocks tetrodotoxin-sensitive Na
+
channels. Potent neurotoxin.
Product Specific Literature References
Non-quantal acetylcholine release at mouse neuromuscular junction: effects of elevated quantal release and aconitine:
S.P. Yu & W. Van der Kloot; Neurosci. Lett.
117
, 111 (1990)
Abstract
Synthesis and activity of a potent N-methyl-D-aspartic acid agonist, trans-1-aminocyclobutane-1,3-dicarboxylic acid, and related phosphonic and carboxylic acids:
M. Muroi, et al.; Neuropharmacology
29
, 567 (1990)
Abstract
Further Categories Containing This Product:
Alkaloids
•
Na+ Channels
ALX-380-024
Revised 30-Oct-07
Actinomycin C
SYNONYMS
Cactinomycin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antitumor Antibiotics
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ALX-380-024-M005
5 mg
40.00 USD
ALX-380-024-M025
25 mg
140.00 USD
Product Specification
CAS NUMBER:
8052-16-2
MERCK INDEX:
14:
1606
SOURCE/HOST:
Isolated from
Streptomyces chrysomallus.
PURITY:
≥98%
APPEARANCE:
Orange solid.
FORMULATION:
Mixture of actinomycin C1(= actinomycin D) (R = R’ = D-Val) ~3%, C2(R = D-Val, R’ = D-allo-Ile) ~45%, C3(R = R’ = D-allo-Ile) ~53%.
SOLUBILITY:
Soluble in methanol. Sparingly soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
Product Description
Antibiotic complex with antitumor activity.
Product Specific Literature References
Nomenclature of the Actinomycins:
S.A. Waksman, et al.; PNAS
44
, 602 (1958)
Abstract
General Information
For nomenclature see S.A. Waksman, E. Katz and L.C. Vining; PNAS
44
, 602 (1958).
Further Categories Containing This Product:
Antitumor Agents (Apoptosis Inducers)
•
Transcription Inhibitors/Related Products
•
Antibiotics - Apoptosis Inducers & Inhibitors
ALX-380-082
Revised 30-Oct-07
Actinomycin C2
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antitumor Antibiotics
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-380-082-C500
500 µg
80.00 USD
Product Specification
FORMULA:
C
63
H
88
N
12
O
16
MW:
1269.5
MERCK INDEX:
14:
1606
SOURCE/HOST:
Isolated from
Streptomyces sp.
PURITY:
≥98% (contains traces of ethylacetate or cyclohexane)
APPEARANCE:
Orange crystals.
SOLUBILITY:
Soluble in methanol, acetone or chloroform.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Keep cool and dry.
HAZARD:
TOXIC.
IDENTITY:
Determined by
1
H-NMR: Identical to standard reference.
Product Description
Antitumor antibiotic.
Product Specific Literature References
Nomenclature of the Actinomycins:
S.A. Waksman, et al.; PNAS
44
, 602 (1958)
Abstract
Actinomycin D, C2 and VII, inhibitors of Grb2-SHC interaction produced by Streptomyces:
J. Y. Nam, et al.; Bioorg. Med. Chem. Lett.
8
, 2001 (1998)
Abstract
Further Categories Containing This Product:
Transcription Inhibitors/Related Products
ALX-380-077
Revised 30-Oct-07
Actinomycin C3
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antitumor Antibiotics
Ordering Information
Product Numbers:
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ALX-380-077-M001
1 mg
70.00 USD
Product Specification
FORMULA:
C
64
H
90
N
12
O
16
MW:
1283.5
MERCK INDEX:
14:
1606
SOURCE/HOST:
Isolated from
Streptomyces sp.
PURITY:
≥98% (solvent free)
APPEARANCE:
Orange crystals.
SOLUBILITY:
Soluble in methanol, acetone or chloroform.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Keep cool and dry.
HAZARD:
TOXIC.
IDENTITY:
Determined by
1
H-NMR: Identical to standard reference.
Product Description
