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 Items 140-160 of 696 Page 8 of 35 Select Page: << 1 2 3 4 5 6 7 8 9 10  >>  
ALX-270-160 Revised 27-Sep-07
Castanospermine
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SYNONYMS (1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyoctahydroindolizine
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-160-M010   10 mg 60.00 USD Add To Cart
ALX-270-160-M050   50 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C8H15NO4
MW: 189.2
CAS NUMBER: 79831-76-8
MERCK INDEX: 14: 1896
SOURCE/HOST: Isolated from Castanospermum australe seeds.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from moisture.

Product Description
Plant alkaloid. Potent inhibitor of α- and β-glucosidase activity in fibroblast extracts; inhibits the glycoprotein processing cycle. Exhibits antiviral properties. Prevents angiogenesis.
Product Specific Literature References
Castanospermine inhibits the processing of the oligosaccharide portion of the influenza viral hemagglutinin: Y.T. Pan, et al.; Biochemistry 22, 3975 (1983) Abstract
Glycoproteins: their structure, biosynthesis and possible clinical implications: H. Schachter; Clin. Biochem. 17, 3 (1984) Abstract
The effects of processing inhibitors of N-linked oligosaccharides on the intracellular migration of glycoprotein E2 of mouse hepatitis virus and the maturation of coronavirus particles: R. Repp, et al.; J. Biol. Chem. 260, 15873 (1985) Abstract; Full Text
Effects of the anti-inflammatory compounds castanospermine, mannose-6- phosphate and fucoidan on allograft rejection and elicited peritoneal exudates: M.R. Bartlett, et al.; Immunol. Cell Biol. 72, 367 (1994) Abstract
Antiviral activity and metabolism of the castanospermine derivative MDL 28,574, in cells infected with herpes simplex virus type 2: S.P. Ahmed, et al.; BBRC 208, 267 (1995) Abstract
The alpha-glucosidase I inhibitor castanospermine alters endothelial cell glycosylation, prevents angiogenesis, and inhibits tumor growth: R. Pili, et al.; Cancer Res. 55, 2920 (1995) Abstract
Perturbation of free oligosaccharide trafficking in endoplasmic reticulum glucosidase I-deficient and castanospermine-treated cells: C. Durrant & S.E. Moore; Biochem. J. 365, 239 (2002) Abstract
Further Categories Containing This Product:
Glycosidases/Related Products • Natural Products - Antiviral/anti-HIV Agents • Natural Products for Angiogenesis Research • Alkaloids
 
 
ALX-385-017 Revised 01-Apr-08
(+)-Catechin . monohydrate
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SYNONYMS (+)-3,3',4',5,7-Flavanpentol
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-385-017-G001   1 g 20.00 USD Add To Cart
Product Specification
FORMULA: C15H14O6 . H2O
MW: 290.3 . 18.0
CAS NUMBER: 88191-48-4, 225937-10-0
MERCK INDEX: 14: 1902
PURITY: ≥98% (TLC)
APPEARANCE: Off-white to yellow powder.
SOLUBILITY: Soluble in 100% ethanol (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: IRRITANT.

Product Description
Antioxidant flavonoid. Free radical scavenger. Has chemopreventive and antitumor properties.
Product Specific Literature References
Adjuvant chemoprevention of experimental cancer: catechin and dietary turmeric in forestomach and oral cancer models: M.A. Azuine & S.V. Bhide; J. Ethnopharmacol. 44, 211 (1994) Abstract
Chemoprevention of mammary tumor virus-induced and chemical carcinogen-induced rodent mammary tumors by natural plant products: S.V. Bhide, et al.; Breast Cancer Res. Treat. 30, 233 (1994) Abstract
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Flavonoids as anticancer agents: structure-activity relationship study: M. Lopez-Lazaro; Curr. Med. Chem. Anticancer Agents 2, 691 (2002), (Review) Abstract
In vitro biological properties of flavonoid conjugates found in vivo: G. Williamson, et al.; Free Radic. Res. 39, 457 (2005), (Review) Abstract
(+)-Catechin prevents ultraviolet B-induced human keratinocyte death via inhibition of JNK phosphorylation: W.B. Wu, et al.; Life Sci. 79, 801 (2006) Abstract
Antispasmodic, bronchodilator and vasodilator activities of (+)-catechin, a naturally occurring flavonoid: M.N. Ghayur, et al.; Arch. Pharm. Res. 30, 970 (2007) Abstract
Further Categories Containing This Product:
Free Radical Scavengers • Flavonoids/Related Products • Natural Products - Antitumor Reagents • Natural Products - Chemopreventive Agents • Active Substances from Fruit and Vegetables
 
 
ALX-385-002 Revised 19-Nov-07
(±)-Catechin
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SYNONYMS (±)-3,3',4',5,7-Flavanpentol
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-385-002-G001   1 g 80.00 USD Add To Cart
Product Specification
FORMULA: C15H14O6
MW: 290.3 (anhydrous basis)
CAS NUMBER: 7295-85-4
MERCK INDEX: 14: 1902
PURITY: ≥98% (HPLC)
APPEARANCE: White to yellow powder.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: IRRITANT.

Product Description
Antioxidant flavonoid. Free radical scavenger. Has chemopreventive and antitumor properties.
Product Specific Literature References
Adjuvant chemoprevention of experimental cancer: catechin and dietary turmeric in forestomach and oral cancer models: M.A. Azuine & S.V. Bhide; J. Ethnopharmacol. 44, 211 (1994) Abstract
Chemoprevention of mammary tumor virus-induced and chemical carcinogen-induced rodent mammary tumors by natural plant products: S.V. Bhide, et al.; Breast Cancer Res. Treat. 30, 233 (1994) Abstract
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Flavonoids as anticancer agents: structure-activity relationship study: M. Lopez-Lazaro; Curr. Med. Chem. Anticancer Agents 2, 691 (2002), (Review) Abstract
In vitro biological properties of flavonoid conjugates found in vivo: G. Williamson, et al.; Free Radic. Res. 39, 457 (2005), (Review) Abstract
(+)-Catechin prevents ultraviolet B-induced human keratinocyte death via inhibition of JNK phosphorylation: W.B. Wu, et al.; Life Sci. 79, 801 (2006) Abstract
Antispasmodic, bronchodilator and vasodilator activities of (+)-catechin, a naturally occurring flavonoid: M.N. Ghayur, et al.; Arch. Pharm. Res. 30, 970 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Antitumor Reagents • Natural Products - Chemopreventive Agents • Free Radical Scavengers • Active Substances from Fruit and Vegetables • Flavonoids/Related Products
 
 
ALX-350-101 Revised 03-Apr-08
Catharanthine . tartrate
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SYNONYMS 3,4-Didehydroibogamine-18-carboxylic acid methyl ester . tartrate
7-Ethyl-9,10,12,13-tetrahydro-6,9-methano-5H-pyrido[1’,2’:1,2]azepino[4,5-b]indole-6(6aH)-carboxylic acid methyl ester . tartrate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cytoskeletal Research
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ALX-350-101-G001   1 g 430.00 USD Add To Cart
ALX-350-101-M100   100 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C21H24N2O2 . C4H6O6
MW: 336.4 . 150.1
CAS NUMBER: 2648-21-5
MERCK INDEX: 14: 1904
SOURCE/HOST: Isolated from Catharanthus roseus.
PURITY: ≥90%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Very hygroscopic. Keep cool and dry.

Product Description

Starting material for the synthesis of the antitumor drugs vinblastine and vincristine.  It is less active as an inhibitor of tubulin self-assembly into microtubules than the latter two compounds.

Product Specific Literature References
Photochemical one-pot synthesis of vinblastine and vincristine: S. Pennanen & A. Huhtikangas; Photochem. Photobiol. 51, 515 (1990) Abstract
Mechanism of interaction of vinca alkaloids with tubulin: catharanthine and vindoline: V. Prakash & S.N. Timasheff; Biochemistry 30, 873 (1991) Abstract
Related Products
Further Categories Containing This Product:
Alkaloids • Microtubule Modulators • Natural Products - Antitumor Reagents
 
 
ALX-380-016 Revised 30-Oct-07
Cefaclor
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SYNONYMS 7-(D-2-Amino-2-phenylacetamido)-3-chloro-3-cephem-4-carboxylic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-016-G001   1 g 150.00 USD Add To Cart
ALX-380-016-G005   5 g 350.00 USD Add To Cart
ALX-380-016-M050   50 mg 20.00 USD Add To Cart
ALX-380-016-M250   250 mg 50.00 USD Add To Cart
Product Specification
FORMULA: C15H14ClN3O4S
MW: 367.8
CAS NUMBER: 53994-73-3
MERCK INDEX: 14: 1912
PURITY: ≥97%
APPEARANCE: Light yellow powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Broad-spectrum antibiotic acting by inhibiting bacterial cell wall synthesis.
Product Specific Literature References
Chemistry of cephalosporin antibiotics. 30. 3-methoxy- and 3-halo-3-cephems: R. R. Chauvette & P. A. Pennington; J. Med. Chem. 18, 403 (1975) Abstract
Cefaclor into the millennium: W. Brumfitt & J. M. Hamilton-Miller; J. Chemother. 11, 163 (1999), (Review) Abstract
Cefaclor revisited: B. R. Meyers; Clin. Ther. 22, 154 (2000), (Review) Abstract
Immunomodulatory properties of cefaclor: in vivo effect on cytokine release and lymphoproliferative response in rats: K. Mangano, et al.; J. Chemother. 18, 641 (2006) Abstract
 
 
ALX-380-044 Revised 16-Oct-07
Cefazolin . sodium salt
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-044-G001   1 g 150.00 USD Add To Cart
ALX-380-044-M250   250 mg 45.00 USD Add To Cart
Product Specification
FORMULA: C14H13N8O4S3 . Na
MW: 453.5 . 23.0
CAS NUMBER: 27164-46-1
MERCK INDEX: 14: 1917
SOURCE/HOST: Semisynthetic.
PURITY: ≥98%
APPEARANCE: Off-white powder.
SOLUBILITY: Soluble in water; slightly soluble in methanol and 100% ethanol; insoluble in acetone, chloroform and benzene.
ACTIVITY: ≥900units/mg.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.

Product Description
Inhibits synthesis of bacterial cell wall.
Product Specific Literature References
Cefazolin, a new semisynthetic cephalosporin antibiotic. II. In vitro and in vivo antimicrobial activity:: M. Nishida, et al.; J. Antibiot. (Tokyo) 23, 137 (1970) Abstract
The effect of beta-lactamase stability, penetration, and target affinity on the activity of cefazolin, cefamandole, cefoxitin, and cefuroxime: P. B. Harper; Clin Ther 6, 310 (1984), Review Abstract
 
 
ALX-380-271 Revised 08-Apr-08 New product
Cefotaxime . sodium salt
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-271-G001   1 g 85.00 USD Add To Cart
ALX-380-271-M250   250 mg 30.00 USD Add To Cart
Product Specification
FORMULA: C16H16N5O7S2 . Na
MW: 454.5 . 23.0
CAS NUMBER: 64485-93-4
MERCK INDEX: 14: 1933
RTECS: XI0250000
APPEARANCE: White to light yellow powder.
SOLUBILITY: Soluble in water (>50mg/ml).
ACTIVITY: Potency is 916-964µg/ml (on dry basis).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Hygroscopic.
HAZARD: HARMFUL.

Product Description
Cephalosporin antibiotic. Inhibits bacterial cell wall synthesis. Effective against Gram-negative and Gram-positive bacteria. Resistant against β-lactamase.
Product Specific Literature References
Synergistic antibacterial interaction of cefotaxime and desacetylcefotaxime: G. Molinari, et al.; J. Chemother. 3, 6 (1991) Abstract
Comparative study of pharmacokinetics and serum bactericidal activity of ceftizoxime and cefotaxime: F. Vallee & M. LeBel; Antimicrob. Agents Chemother. 35, 2057 (1991) Abstract; Full Text
 
 
ALX-350-332 Revised 03-Apr-08
Celastrol
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SYNONYMS Tripterine
3-Hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Anti-inflammatory Agents
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ALX-350-332-M005   5 mg 65.00 USD Add To Cart
ALX-350-332-M025   25 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C29H38O4
MW: 450.6
CAS NUMBER: 34157-83-0
SOURCE/HOST: Isolated from the root of Tripterygium sp.
PURITY: ≥98% (HPLC)
APPEARANCE: Red cubic crystals.
SOLUBILITY: Soluble in 100% ethanol, DMSO or dimethyl formamide; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Cell permeable triterpenoid anti-inflammatory and immunosuppressive compound. Antioxidant. Suppresses LPS-induced cytokine release in macrophages and monocytes (IC50=40nM for IL-1β and IL-1α, 80nM for IL-6, 110nM for prostaglandin E2 and 210nM for IL-8 and TNF-α). Suppresses nitric oxide (NO) production (IC50=230nM) and LPS-induced NF-κB activation (IC50=270nM). Inhibits chymotrypsin-like activity of 20S proteasome (IC50=2.5µM). Inhibits lipid peroxidation induced by ADP and Fe2+ in rat liver mitochondria (IC50=7µM). Induces expression of a wider set of heat shock proteins. Inhibits topoisomerse II.
Product Specific Literature References
The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria: H. Sassa, et al.; BBRC 172, 890 (1990) Abstract
Structural basis of potent antiperoxidation activity of the triterpene celastrol in mitochondria: effect of negative membrane surface charge on lipid peroxidation: H. Sassa, et al.; Free Radic. Biol. Med. 17, 201 (1994) Abstract
Novel cytokine release inhibitors. Part III: Truncated analogs of tripterine: W. He, et al.; Bioorg. Med. Chem. Lett. 8, 3659 (1998) Abstract
Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer’s disease: A.C. Allison, et al.; Prog. Neuropsychopharmacol. Biol. Psychiatry 25, 1341 (2001) Abstract
Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-kappaB activation and NO production: H.Z. Jin, et al.; J. Nat. Prod. 65, 89 (2002) Abstract
Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by triterpene celastrol: M. Nagase, et al.; Biosci. Biotechnol. Biochem. 67, 1883 (2003) Abstract; Full Text
Celastrol inhibits pro-inflammatory cytokine secretion in Crohn’s disease biopsies: G.F. Pinna, et al.; BBRC 322, 778 (2004) Abstract
Celastrols as inducers of the heat shock response and cytoprotection: S.D. Westerheide, et al.; J. Biol. Chem. 279, 56053 (2004) Abstract; Full Text
Celastrol protects against MPTP- and 3-nitropropionic acid-induced neurotoxicity: C. Cleren, et al.; J. Neurochem. 94, 995 (2005) Abstract
Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis: M. Kiaei, et al.; Neurodegener. Dis. 2, 246 (2005) Abstract
Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice: H. Yang, et al.; Cancer Res. 66, 4758 (2006) Abstract; Full Text
Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation: G. Sethi, et al.; Blood 109, 2727 (2007) Abstract
Induction of heat shock proteins in differentiated human and rodent neurons by celastrol: A.M. Chow & I.R. Brown; Cell Stress Chaperones 12, 237 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Nitric Oxide Pathway Modulators • Stress & Heat Shock Proteins Other Products • Natural Products - Immunomodulators • Natural Products - Topoisomerase Inhibitors • Natural Products - Antioxidants • NF-kB Pathway Inhibitors • Ubiquitin & Proteasome Other Products
 
 
ALX-380-053 Revised 19-Jun-08
Cerulenin
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SYNONYMS 2,3-Epoxy-4-oxo-7,10-dodecadienamide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Apoptosis Inducers & Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-053-M005   5 mg 60.00 USD Add To Cart
ALX-380-053-M010   10 mg 110.00 USD Add To Cart
ALX-380-053-M050   50 mg 420.00 USD Add To Cart
Product Specification
FORMULA: C12H17NO3
MW: 223.3
CAS NUMBER: 17397-89-6
MERCK INDEX: 14: 2004
RTECS: JR1670000
SOURCE/HOST: Isolated from Cephalosporium caerulens.
PURITY: