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ALX-167-024
Revised 17-May-06
SN50
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
NF-kB Pathway Inhibitors
Ordering Information
Product Numbers:
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Size:
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ALX-167-024-C500
500 µg
125.00 USD
Product Specification
SEQUENCE:
H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH
FORMULA:
C
129
H
230
N
36
O
29
S
MW:
2781.5
PEPTIDE CONTENT:
50-75%
PURITY:
≥96% (HPLC)
APPEARANCE:
White to off-white solid.
FORMULATION:
Counter Ion:
Trifluoroacetate salt.
SOLUBILITY:
Soluble in distilled water, 100% ethanol or ethanol:water 1:1.
RECONSTITUTION:
Reconstitute in sterile distilled water.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Peptides in solution have limited stability.
HANDLING:
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Description
Inhibits translocation of the NF-κB active complex into the nucleus. In mouse endothelial LE-II cells induced with LPS, inhibition of NF-κB nuclear translocation was 88% at 50µg/ml (18µM). In human monocytic THP-1 cells induced by LPS or TNF-α there was 85% inhibition at 100µg/ml.
For control peptide, see SN50M (Prod. No.
ALX-167-025
).
Product Specific Literature References
Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence:
Y.Z. Lin, et al.; J. Biol. Chem.
270
, 14255 (1995)
Abstract
;
Full Text
p38 MAP kinase and MKK-1 co-operate in the generation of GM-CSF from LPS-stimulated human monocytes by an NF-kappa B-independent mechanism:
K.K. Meja, et al.; Br. J. Pharmacol.
131
, 1143 (2000)
Abstract
Nuclear factor-kappaB activates dual inhibition sites in the regulation of tumor necrosis factor-alpha-induced neutrophil apoptosis:
M. Niwa, et al.; Eur. J. Pharmacol
407
, 211 (2000)
Abstract
Activation of nuclear factor kappaB and induction of apoptosis by tumor necrosis factor-alpha in the mouse uterine epithelial WEG-1 cell line:
S. Pampfer, et al.; Biol. Reprod.
63
, 879 (2000)
Abstract
Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells
:
Y. Dai, et al.; Blood
103
, 2761 (2004)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Nuclear localization sequence (NLS) aa 360-369 (AAVALLPAVLLALLAPVQRKRQKLMP) of the transcription factor NF-κB p50 linked to a peptide cell-permeablization sequence, the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF).
Further Categories Containing This Product:
Nuclear Envelope & Nuclear Transport
•
Peptides
ALX-167-025
Revised 17-May-06
SN50M Control Peptide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
NF-kB Pathway Inhibitors
Ordering Information
Product Numbers:
Format:
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ALX-167-025-C500
500 µg
125.00 USD
Product Specification
SEQUENCE:
H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Pro-Val-Gln-Arg-Asn-Gly-Gln-Lys-Leu-Met-Pro-OH
FORMULA:
C
123
H
215
N
33
O
30
S
MW:
2668.4
PEPTIDE CONTENT:
70-90%
PURITY:
≥97% (HPLC)
APPEARANCE:
White to off-white solid.
FORMULATION:
Counter Ion:
Trifluoroacetate salt.
SOLUBILITY:
Soluble in water.
RECONSTITUTION:
Reconstitute in sterile distilled water.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Peptides in solution have limited stability.
HANDLING:
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Description
Inactive control peptide for SN50 (Prod. No.
ALX-167-024
). In mouse endothelial LE-II cells, induced with LPS, 50µg/ml SN50M had no measurable effect on NF-κB translocation. In human monocytic THP-1 cells induced by LPS or TNF-α there was slight inhibition at 100µg/ml.
Product Specific Literature References
Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence
:
Y.Z. Lin, et al.; J. Biol. Chem.
270
, 14255 (1995)
Abstract
;
Full Text
Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells
:
Y. Dai, et al.; Blood
103
, 2761 (2004)
Abstract
Further Categories Containing This Product:
Nuclear Envelope & Nuclear Transport
•
Peptides
ALX-167-004
Revised 12-Jun-03
Somatostatin-14
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Somatostatin & Somatostatin Receptors/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-167-004-P001
1 mg*
20.00 USD
ALX-167-004-P005
5 mg*
80.00 USD
Product Specification
SEQUENCE:
H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH
(Disulfide bond between Cys
3
-Cys
14
)
FORMULA:
C
76
H
104
N
18
O
19
S
2
MW:
1637.9
CAS NUMBER:
51110-01-1
MERCK INDEX:
14:
8715
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥98%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in 5% acetic acid.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Further Categories Containing This Product:
Peptides
ALX-166-002
Revised 07-Feb-05
R-R-SRC-Peptide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Src Family Kinases/Related Products
Ordering Information
Product Numbers:
Format:
Size:
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ALX-166-002-M001
1 mg
80.00 USD
ALX-166-002-M005
5 mg
350.00 USD
Product Specification
SEQUENCE:
H-Arg-Arg-Leu-Ile-Glu-Asp-Ala-Glu-Tyr-Ala-Ala-Arg-Gly-OH
FORMULA:
C
64
H
106
N
22
O
21
MW:
1519.7
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Substrate for protein tyrosine kinases. The peptide sequence corresponds to the tyrosine phosphorylation site in the
Rous sarcoma
virus (RSV)-encoded transforming protein pp60
v-src
.
In vitro
tyrosine phosphorylation of the peptide is stimulated by epidermal growth factor (EGF).
Product Specific Literature References
Phosphorylation of synthetic peptides by a tyrosine protein kinase from the particulate fraction of a lymphoma cell line:
J.E. Casnellie, et al.; PNAS
79
, 282 (1982)
Abstract
Characterization of affinity-purified insulin receptor/kinase. Effects of dithiothreitol on receptor/kinase function:
L.J. Pike, et al.; J. Biol. Chem.
261
, 3782 (1986)
Abstract
;
Full Text
Further Categories Containing This Product:
Peptides
ALX-167-003
Revised 15-Oct-07
Substance P
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Substance P and Analogs
Ordering Information
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ALX-167-003-M001
1 mg
30.00 USD
ALX-167-003-M005
5 mg
90.00 USD
Product Specification
SEQUENCE:
H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH
2
FORMULA:
C
63
H
98
N
18
O
13
S
MW:
1347.6
CAS NUMBER:
33507-63-0
MERCK INDEX:
14:
8863
PURITY:
≥97% (HPLC)
APPEARANCE:
Lyophilized.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Neuropeptide inducing Ca
2+
mobilization. Activates G
1
-Proteins directly. Induces superoxide production in neutrophils.
Product Specific Literature References
A.M. Garland, et al.; Soc. Neurosci.
19
, 104 (1993), Abstract
J.Y. Wei, et al.; Soc. Neurosci.
19
, 136 (1993), Abstract
Substance P elevates intracellular calcium in both neurons and glial cells from the dorsal horn of the spinal cord:
M.J. Heath, et al.; J. Neurophysiol.
72
, 1192 (1994)
Abstract
Neuropeptide Y promotes GTP photo-incorporation into a 55 kDa protein:
J. Zhu, et al.; Eur. J. Pharmacol.
268
, 279 (1994)
Abstract
Sera from patients with falciparum malaria induce substance P gene expression in cultured human brain microvascular endothelial cells:
C.B. Chiwakata, et al.; Infect. Immun.
64
, 5106 (1996)
Abstract
Intracellular signaling pathway of substance P-induced superoxide production in human neutrophils:
T. Tanabe, et al.; Eur. J. Pharmacol.
299
, 187 (1996)
Abstract
Further Categories Containing This Product:
Peptides
ALX-165-002
Revised 04-Jul-03
[D-Trp7,9,10]-Substance P
SYNONYMS
GP Antagonist-2 Analog
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Substance P and Analogs
Ordering Information
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ALX-165-002-M001
1 mg
60.00 USD
ALX-165-002-M005
5 mg
240.00 USD
Product Specification
SEQUENCE:
H-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-D-Trp-Met-NH
2
FORMULA:
C
79
H
105
N
21
O
13
S
MW:
1588.9
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Potent, selective inhibitor of M1 mAChR-promoted GTP hydrolysis by G
q/11
, whereas not effective in inhibiting M2 mAChR-promoted GTP hydrolysis by G
i
.
Product Specific Literature References
Biological evaluation of substance P antagonists:
K. Folkers, et al.; Br. J. Pharmacol.
83
, 449 (1984)
Abstract
G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding:
H. Mukai, et al.; J. Biol. Chem.
267
, 16237 (1992)
Abstract
;
Full Text
Further Categories Containing This Product:
Peptides
ALX-167-007
Revised 12-Jun-03
Syntide 2
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
CAM Kinase Substrates
Ordering Information
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ALX-167-007-M001
1 mg
70.00 USD
ALX-167-007-M005
5 mg
280.00 USD
Product Specification
SEQUENCE:
H-Pro-Leu-Ala-Arg-Thr-Leu-Ser-Val-Ala-Gly-Leu-Pro-Gly-Lys-Lys-OH
FORMULA:
C
68
H
122
N
20
O
18
MW:
1507.8
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Substrate for Ca
2+
/calmodulin-dependent protein kinase II and protein kinase C (PKC). The peptide sequence is homologous to the phosphorylation site 2 in glycogen synthase.
Product Specific Literature References
Calcium . calmodulin-dependent protein kinase II and calcium . phospholipid-dependent protein kinase activities in rat tissues assayed with a synthetic peptide:
Y. Hashimoto & T.R. Soderling; Arch. Biochem. Biophys.
252
, 418 (1987)
Abstract
Further Categories Containing This Product:
Peptides
•
PKC Substrates
ALX-168-010
Revised 14-Aug-06
D-TAT Control Peptide (for Prod. No. ALX-159-601)
SYNONYMS
JNK Inhibitor 1 (D-stereoisomer) Control Peptide (for Prod. No.
ALX-159-601
)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
JNK [SAPK1]/Related Products
Ordering Information
Product Numbers:
Format:
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ALX-168-010-R025
25 µl
95.00 USD
ALX-168-010F-R025
FITC
25 µl
145.00 USD
Product Specification
SEQUENCE:
Unconjugated peptide
: rrrqrrkkr-amide
FITC-conjugated peptide
: FITC-β-a-rkkrrqrrra-amide
FORMULA:
Unconjugated peptide:
C
53
H
107
N
31
O
10
FITC-conjugated peptide:
C
80
H
128
N
34
O
17
S
MW:
Unconjugated peptide:
1338.6
FITC-conjugated peptide:
1870.2
CONCENTRATION:
1mM
PURITY:
≥95% (HPLC)
FORMULATION:
Liquid. In sterile PBS.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Protect from moisture. Avoid freeze/thaw cycles. Keep on ice at all times.
Product Images
Please click on thumbnails to enlarge.
Product Description
Control peptide for D-JNKI. For more details see JNK Inhibitor 1 (D-stereoisomer) (Prod. No.
ALX-159-601
).
Product Specific Literature References
Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death:
C. Bonny, et al.; Diabetes
50
, 77 (2001)
Abstract
;
Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION
Note:
D-TAT consists of D-amino acids. The sequence of unconjugated D-TAT is retro-inverse compared to L-TAT.
Further Categories Containing This Product:
Peptides
ALX-168-009/1
Revised 22-Jul-08
L-TAT Control Peptide (for Prod. No. ALX-159-600)
SYNONYMS
JNK Inhibitor 1 (L-stereoisomer) Control Peptide (for Prod. No.
ALX-159-600
)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
JNK [SAPK1]/Related Products
Ordering Information
Product Numbers:
Format:
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ALX-168-009/1-R050
50 µl
40.00 USD
Product Specification
SEQUENCE:
GRKKRRQRRR-amide
FORMULA:
C
55
H
109
N
31
O
12
MW:
1396.6
CONCENTRATION:
10mM
PURITY:
≥85% (HPLC)
FORMULATION:
Liquid. Sterile solution in water.
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
HANDLING:
After opening, prepare aliquots and store at -80°C. Avoid freeze/thaw cycles. Keep on ice at all times.
Product Description
Control peptide for L-JNKI. For more details see L-JNKI1 (Prod.No.
ALX-159-600
).
Product Specific Literature References
Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death:
C. Bonny, et al.; Diabetes
50
, 77 (2001)
Abstract
;
Full Text
Hyperosmolarity and CD95L trigger CD95/EGF receptor association and tyrosine phosphorylation of CD95 as prerequisites for CD95 membrane trafficking and DISC formation:
R. Reinehr, et al.; FASEB J.
17
, 731 (2003)
Abstract
;
Full Text
Related Products
ALX-159-600
JNK Inhibitor 1 (L-stereoisomer)
ALX-152-027
Bim
L
(147-164) (human) (cell permeable)
ALX-152-028
Bax (58-75) (human) (cell permeable)
ALX-163-011
NBD Peptide / NF-κB Blocker (cell permeable)
ALX-152-029
Bok (66-83) (human) (cell permeable)
Further Categories Containing This Product:
Peptides
ALX-168-004
Revised 02-Apr-03
H-Tyr-Ile-Tyr-Gly-Ser-Phe-Lys-OH
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Src Family Kinases/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-168-004-M001
1 mg
90.00 USD
ALX-168-004-M005
5 mg
360.00 USD
Product Specification
FORMULA:
C
44
H
60
N
8
O
11
MW:
877.0
PURITY:
97%
APPEARANCE:
White lyophilized powder.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Peptide selected from a random combinatorial peptide library. Specific and efficient substrate for the
Src
-family protein tyrosine kinase than cdc2 (6-20).
Product Specific Literature References
Identification and characterization of a novel synthetic peptide substrate specific for Src-family protein tyrosine kinases:
K.S. Lam, et al.; Int. J. Peptide Protein Res.
45
, 587 (1995)
Abstract
Further Categories Containing This Product:
Peptides
ALX-168-005
Revised 04-Mar-05
Tyrosine Hydroxylase (24-33) (rat)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
MAPK Pathway Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-168-005-M001
1 mg
