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ALX-350-241 Revised 07-Dec-07
Manumycin A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Other Signal Transduction Pathway Modulators
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-241-M001   1 mg 58.00 USD Add To Cart
ALX-350-241-M005   5 mg 170.00 USD Add To Cart
ALX-350-241-M010   10 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C31H38N2O7
MW: 550.7
CAS NUMBER: 52665-74-4
SOURCE/HOST: Isolated from Streptomyces parvulus.
PURITY: ≥96% (HPLC)
APPEARANCE: Yellow to brown powder.
SOLUBILITY: Soluble in methanol or DMSO; insoluble in water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Determined by 1H-NMR.

Product Description
Potent, selective and competitive inhibitor of Ras farnesyltransferase. Does not affect geranylgeranyltransferase. Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras. Inhibits neutral sphingomyelinase.
Product Specific Literature References
Inhibitors of Ras farnesyltransferases: F. Tamanoi; TIBS 18, 349 (1993), (Review) Abstract
Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic: J.B. Gibbs, et al.; Cell 77, 175 (1994) Abstract
Manumycin inhibits ras signal transduction pathway and induces apoptosis in COLO320-DM human colon tumour cells: A. Di Paolo, et al.; Br. J. Cancer 82, 905 (2000) Abstract
Manumycin A and its analogues are irreversible inhibitors of neutral sphingomyelinase: C. Arenz, et al.; ChemBioChem 2, 141 (2001) Abstract
Enhancement of manumycin A-induced apoptosis by methoxyamine in myeloid leukemia cells: M. She, et al.; Leukemia 19, 595 (2005) Abstract
Binding of manumycin A inhibits IkappaB kinase beta activity: M. Bernier, et al.; J. Biol. Chem. 281, 2551 (2006) Abstract
Further Categories Containing This Product:
Farnesylation/Isoprenylation Reagents • Ceramides/Cerebrosides/Sphingolipids/Related Products • Antibiotics - Apoptosis Inducers & Inhibitors
 
 
ALX-350-294 Revised 16-Jun-08
Manzamine A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Anti-inflammatory Agents
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ALX-350-294-M001   1 mg 195.00 USD Add To Cart
Product Specification
FORMULA: C36H44N4O
MW: 548.8
CAS NUMBER: 104196-68-1
SOURCE/HOST: Isolated from Xestospongia sp.
PURITY: >98% (HPLC)
FORMULATION: Yellow oil
SOLUBILITY: Soluble in DMSO, methanol or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
β-Carboline alkaloid with anti-inflammatory, antimalarial, antifungal, anti-HIV-1and insecticidal activity. Also active against the Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus. Inhibits GSK-3. Has native fluorescence, highest when solubilized in methanol (Ex: 340nm, Em: 387nm).
Product Specific Literature References
Four new bioactive manzamine-type alkaloids from the Philippine marine sponge Xestospongia ashmorica: R.A. Edrada, et al.; J. Nat. Prod. 59, 1056 (1996) Abstract
In vivo antimalarial activity of the beta-carboline alkaloid manzamine A: K.K. Ang, et al.; Antimicrob. Agents Chemother. 44, 1645 (2000) Abstract; Full Text
Immune-mediated parasite clearance in mice infected with Plasmodium berghei following treatment with manzamine A: K.K. Ang, et al.; Parasitol. Res. 87, 715 (2001) Abstract
New manzamine alkaloids with activity against infectious and tropical parasitic diseases from an Indonesian sponge: K.V. Rao, et al.; J. Nat. Prod. 66, 823 (2003) Abstract
Spectrofluorimetric determination of manzamine A in spiked human urine and plasma: A. Khalil, et al.; Pharmazie 58, 385 (2003) Abstract
New manzamine alkaloids from an Indo-Pacific sponge. Pharmacokinetics, oral availability, and the significant activity of several manzamines against HIV-I, AIDS opportunistic infections, and inflammatory diseases: M. Yousaf, et al.; J. Med. Chem. 47, 3512 (2004) Abstract
Antimalarial activity of a new family of analogues of manzamine A: J.D. Winkler, et al.; Org. Lett. 8, 2591 (2006) Abstract
Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer’s disease: M. Hamann, et al.; J. Nat. Prod. 70, 1397 (2007) Abstract
Further Categories Containing This Product:
Malaria/Related Products • Natural Products - Antiviral/anti-HIV Agents • Natural Products with Antibiotic Activity • Natural Products - Antifungal Agents • Alkaloids • Natural Products - Antimalarial Agents • GSK-3 Inhibitors • Pesticides/Related Products
 
 
ALX-630-045 Revised 07-Apr-08
Margatoxin
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SYNONYMS MgTx
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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ALX-630-045-C100   100 µg 520.00 USD Add To Cart
Product Specification
SEQUENCE: H-Thr-Ile-Ile-Asn-Val-Lys-Cys-Thr-Ser-Pro-Lys-Gln-Cys-Leu-Pro-Pro-Cys-Lys-Ala-Gln-Phe-Gly-Gln-Ser-Ala-Gly-Ala-Lys-Cys-Met-Asn-Gly-Lys-Cys-Lys-Cys-Tyr-Pro-His-OH
(Disulfide bonds between Cys7-Cys29, Cys13-Cys34 and Cys17-Cys36)
FORMULA: C178H286N52O50S7
MW: 4179.0
SOURCE/HOST: Synthetic. Originally isolated from Centruroides margaritatus.
APPEARANCE: Lyophilized.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: POTENT NEUROTOXIN.
Product Description
Voltage dependent K+ channel blocker (specific for Kv1.3 channel). Inhibitor of T cell activation. Immunosuppressor.
Product Specific Literature References
Selective blockers of voltage-gated K+ channels depolarize human T lymphocytes: mechanism of the antiproliferative effect of charybdotoxin: R.J. Leonard, et al.; PNAS 89, 10094 (1992) Abstract
Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels: M. Garcia-Calvo, et al.; J. Biol. Chem. 268, 18866 (1993) Abstract; Full Text
Chemical synthesis and structure-function studies of margatoxin, a potent inhibitor of voltage-dependent potassium channel in human T lymphocytes: M.A. Bednarek, et al.; Biochem. Biophys. Res. Commun. 198, 619 (1994) Abstract
[125I]margatoxin, an extraordinarily high affinity ligand for voltage-gated potassium channels in mammalian brain: H.G. Knaus, et al.; Biochemistry 34, 13627 (1995) Abstract
Margatoxin increases dopamine release in rat striatum via voltage-gated K+ channels: A. Saria, et al.; Eur. J. Pharmacol. 343, 193 (1998) Abstract
Immunosuppressive effects of a Kv1.3 inhibitor: K. Shah, et al.; Cell Immunol3 221, 100 (2003) Abstract
Margatoxin inhibits VEGF-induced hyperpolarization, proliferation and nitric oxide production of human endothelial cells: A. Erdogan, et al.; J. Vasc. Res. 42, 368 (2005) Abstract
Characterization of the functional properties of the voltage-gated potassium channel Kv1.3 in human CD4+ T lymphocytes: L. Hu, et al.; J. Immunol. 179, 4563 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Immunomodulators • K+ Channel Blockers & Inhibitors
 
 
ALX-162-001 Revised 07-Apr-08
Mastoparan
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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ALX-162-001-M001   1 mg 50.00 USD Add To Cart
ALX-162-001-M005   5 mg 200.00 USD Add To Cart
Product Specification
SEQUENCE: H-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH2
FORMULA: C70H131N19O15
MW: 1478.9
CAS NUMBER: 72093-21-1
SOURCE/HOST: Synthetic. Originally isolated from wasp venom.
PURITY: ≥98%
APPEARANCE: White lyophilized powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: POTENT NEUROTOXIN.
Product Description

Mast cell degranulating peptide. Stimulates glycogenolysis.Stimulates phospholipase D2 PLD2 activity. Alters G-proteins in brain membranes.
Product Specific Literature References
A new mast cell degranulating peptide "mastoparan" in the venom of Vespula lewisii: Y. Hirai, et al.; Chem. Pharm. Bull. 27, 1942 (1979) Abstract
Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins): T. Higashijima, et al.; J. Biol. Chem. 263, 6491 (1988) Abstract; Full Text
Mastoparan, a peptide toxin from wasp venom, stimulates glycogenolysis mediated by an increase of the cytosolic free Ca2+ concentration but not by an increase of cAMP in rat hepatocytes: M. Tohkin, et al.; FEBS Lett. 260, 179 (1990) Abstract
Interaction of wasp venom mastoparan with biomembranes: T. Katsu, et al.; Biochim. Biophys. Acta 1027, 185 (1990) Abstract
Effects of the wasp venom peptide, mastoparan, on GTP hydrolysis in rat brain membranes: Y. Odagaki, et al.; Br. J. Pharmacol. 121, 1406 (1997) Abstract
Mastoparan selectively activates phospholipase D2 in cell membranes: A. Chahdi, et al.; J. Biol. Chem. 278, 12039 (2003) Abstract
Mastoparan, a G protein agonist peptide, differentially modulates TLR4- and TLR2-mediated signaling in human endothelial cells and murine macrophages: A. Lentschat, et al.; J. Immunol. 174, 4252 (2005) Abstract
Biological applications of the receptor mimetic peptide mastoparan: S. Jones & J. Howl; Curr. Protein Pept. Sci. 7, 501 (2006), Review Abstract
Further Categories Containing This Product:
G-proteins & GTPases Other Products • Peptides
 
 
ALX-162-002 Revised 07-Apr-08
MCD Peptide
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SYNONYMS Mast Cell Degranulating Peptide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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ALX-162-002-MC05   0.5 mg 360.00 USD Add To Cart
Product Specification
SEQUENCE: H-Ile-Lys-Cys-Asn-Cys-Lys-Arg-His-Val-Ile-Lys-Pro-His-Ile-Cys-Arg-Lys-Ile-Cys-Gly-Lys-Asn-NH2
(Disulfide bonds between Cys3-Cys15 and Cys5-Cys19)
FORMULA: C110H192N40O24S4
MW: 2587.2
CAS NUMBER: 83856-13-7
SOURCE/HOST: Synthetic. Originally isolated from Apis mellifera.
PURITY: ≥98%
APPEARANCE: White lyophilized powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: POTENT NEUROTOXIN.
Product Description
Potent anti-inflammatory agent and strong mediator of mast cell degranulation and histamine release. Neurotoxin and voltage-dependent K+ channel blocker. Inhibits the ADP-ribosylation of the small GTP-binding proteins rho.
Product Specific Literature References
Bee and wasp venoms: E. Haberman; Science 177, 314 (1972) Abstract
Potassium channel toxins: P.N. Strong; Pharmacol. Ther. 46, 137 (1990) Abstract
Mast cell degranulating peptide: a multi-functional neurotoxin: M.R. Ziai, et al.; J. Pharm. Pharmacol. 42, 457 (1990), Review Abstract
ADP-ribosylation of rho proteins is inhibited by melittin, mast cell degranulating peptide and compound 48/80: G. Koch, et al.; Eur. J. Pharmacol. 226, 87 (1992) Abstract
Further Categories Containing This Product:
Peptides • K+ Channel Blockers & Inhibitors • Natural Products - Anti-inflammatory Agents
 
 
ALX-350-297 Revised 07-Apr-08
Meleagrin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-350-297-M001   1 mg 195.00 USD Add To Cart
Product Specification
FORMULA: C23H23N5O4
MW: 433.5
CAS NUMBER: 71751-77-4
SOURCE/HOST: Isolated from Penicillium meleagrinum.
PURITY: ≥98 (HPLC)
APPEARANCE: Yellow oil.
SOLUBILITY: Soluble in 100% ethanol or DMSO.
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Antibiotic.
Product Specific Literature References
The biosynthesis of low-molecular-weight nitrogen-containing secondary metabolite-alkaloids by the resident strains of Penicillium chrysogenum and Penicillium expansum isolated on the board of the Mir space station: A.G. Kozlovskii, et al.; Mikrobiologiia 71, 773 (2002) Abstract
Formation of alkaloids from Penicillium species fungi during growth on wheat kernels: N.G. Vinokurova, et al.; Prikl. Biokhim. Mikrobiol. 39, 457 (2003) Abstract
Roquefortine/oxaline biosynthesis pathway metabolites in Penicillium ser. Corymbifera: in planta production and implications for competitive fitness: D.P. Overy, et al.; J. Chem. Ecol. 31, 2373 (2005) Abstract
Further Categories Containing This Product:
Alkaloids
 
 
ALX-162-006 Revised 07-Apr-08
Melittin (natural)
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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ALX-162-006-M001   1 mg 40.00 USD Add To Cart
ALX-162-006-M005   5 mg 160.00 USD Add To Cart
Product Specification
SEQUENCE: H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2
FORMULA: C131H229N39O31
MW: 2846.5
CAS NUMBER: 37231-28-0
MERCK INDEX: 14: 5824
RTECS: OS3960000
SOURCE/HOST: Isolated from bee venom.
PURITY: ≥85% (HPLC)
APPEARANCE: Off-white to faint tan powder.
PURITY DETAIL: Phospholipase A2 impurity: <5 units per mg solid.
SOLUBILITY: Soluble in PBS (5mg/ml) or water (5mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Very hygroscopic. Protect from light.
HAZARD: HARMFUL.
Product Description
Causes disruption of normal cellular activity and cell lysis. Binds calmodulin in a calcium-dependent manner. Activates phospholipase A2 (PLA2) and inhibits protein kinase C (PKC) by binding to the catalytic domain in a Mg-ATP sensitive manner. Antirheumatic.
Product Specific Literature References
Rapid purification of calmodulin and S-100 protein by affinity chromatography with melittin immobilized to sepharose: R.L. Kincaid & C.C. Coulson; BBRC 133, 256 (1985) Abstract
Comparison of S100b protein with calmodulin: interactions with melittin and microtubule-associated tau proteins and inhibition of phosphorylation of tau proteins by protein kinase C: J. Baudier, et al.; Biochemistry 26, 2886 (1987) Abstract
Possible mechanisms of action of cobra snake venom cardiotoxins and bee venom melittin: J.E. Fletcher & M.S. Jiang; Toxicon. 31, 669 (1993) Abstract
Melittin and phospholipase A2 from bee (Apis mellifera) venom cause necrosis of murine skeletal muscle in vivo: C.L. Ownby, et al.; Toxicon. 35, 67 (1997) Abstract
Melittin binds to secretory phospholipase A2 and inhibits its enzymatic activity: S.S. Saini, et al.; BBRC 238, 436 (1997) Abstract
Phospholipase A2-independent Ca2+ entry and subsequent apoptosis induced by melittin in human MG63 osteosarcoma cells: S.T. Chu, et al.; Life Sci. 80, 364 (2007) Abstract
Further Categories Containing This Product:
Calmodulin Other Products • PKC Inhibitors • Peptides • PLA2 Activators
 
 
ALX-162-007 Revised 12-May-05
Melittin (synthetic)
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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ALX-162-007-MC05   0.5 mg 70.00 USD Add To Cart
ALX-162-007-M001   1 mg 120.00 USD Add To Cart
Product Specification
SEQUENCE: H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2
FORMULA: C131H229N39O31
MW: 2846.5
CAS NUMBER: 37231-28-0
MERCK INDEX: 14: 5824
SOURCE/HOST: Synthetic.
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.
Product Description
For technical information see melittin (natural) (Prod. No. ALX-162-006).
Further Categories Containing This Product:
PLA2 Activators • Calmodulin Other Products • PKC Inhibitors • Peptides
 
 
ALX-460-007 Revised 02-Feb-07
Menadione
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SYNONYMS Vitamin K3
2-Methyl-1,4-naphthoquinone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Vitamins
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ALX-460-007-G010   10 g 10.00 USD Add To Cart
Product Specification
FORMULA: C11H8O2
MW: 172.2
CAS NUMBER: 58-27-5
MERCK INDEX: 14: 5831
RTECS: QL9100000
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow crystals.
SOLUBILITY: Soluble in 96% ethanol (16mg/ml) or DMSO (1mg/ml); almost insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.
HAZARD: HARMFUL.

Product Description
Cytotoxic in various cell lines. Induces apoptosis via elevation of peroxide and superoxide radical levels. Affects gap-junctional intercellular communication by mediation of tyrosine phosphorylation.
Product Specific Literature References
Vitamin K3 induces cell cycle arrest and cell death by inhibiting Cdc25 phosphatase: F.Y. Wu and T.P.; Eur. J. Cancer 35, 1388 (1999) Abstract
Apoptosis-inducing activity of vitamin C and vitamin K: H. Sakagami, et al.; Cell Mol. Biol. 46, 129 (2000) Abstract
Cytotoxic effect through fas/APO-1 expression due to vitamin K in human glioma cells: L.K. Sun, et al.; J. Neurooncol. 47, 31 (2000) Abstract
Cytotoxic activity of vitamins K1, K2 and K3 against human oral tumor cell lines: H. Okayasu, et al.; Anticancer Res. 21, 2387 (2001) Abstract
2-Methyl-1,4-naphthoquinone, vitamin K(3), decreases gap-junctional intercellular communication via activation of the epidermal growth factor receptor/extracellular signal-regulated kinase cascade: L.O. Klotz, et al.; Cancer Res. 62, 4922 (2002) Abstract; Full Text
Menadione metabolism to thiodione in hepatoblastoma by scanning electrochemical microscopy: J. Mauzeroll, et al.; PNAS 101, 17582 (2004) Abstract; Full Text
Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells: D.N. Criddle, et al.; J. Biol. Chem. 281, 40485 (2006) Abstract; Full Text
Further Categories Containing This Product:
Antitumor Agents (DNA Interaction & Gene Regulation) • Antitumor Agents (Apoptosis Inducers) • Cell Stress, Oxidative Stress & Redox Signalling Other Products
 
 
ALX-380-131 Revised 12-Aug-08 New product
Mensacarcin