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Amanitins & Phalloidins / Related Products
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ALX-350-265 Revised 17-Dec-07
Phalloidin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cytoskeletal Research
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ALX-350-265-M001   1 mg 135.00 USD Add To Cart
Product Specification
FORMULA: C35H48N8O11S
MW: 788.9
CAS NUMBER: 17466-45-4
MERCK INDEX: 14: 7196
SOURCE/HOST: Isolated from Amanita phalloides mushrooms.
PURITY: ≥95%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO, dimethyl formamide, methanol, 100% ethanol or water (warm).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: VERY TOXIC.

Product Description
Binds to polymeric actin with high affinity. Stabilizes filaments and decreases concentration of monomeric actin.
Product Specific Literature References
Interaction of phalloidin with actin: A.M. Lengsfeld, et al.; PNAS 71, 2803 (1974) Abstract
Interaction of actin with phalloidin: polymerization and stabilization of F-actin: P. Dancker, et al.; Biochim. Biophys. Acta 400, 407 (1975) Abstract
Phalloidin-induced actin polymerization in the cytoplasm of cultured cells interferes with cell locomotion and growth: J. Wehland, et al.; PNAS 74, 5613 (1977) Abstract
What we have learned from phalloidin: M. Frimmer; Toxicol Lett. 35, 169 (1987) Abstract
Effects of cytochalasin and phalloidin on actin: J.A. Cooper; J. Cell. Biol. 105, 1473 (1987), (Review) Abstract
Position and orientation of phalloidin in F-actin determined by X-ray fiber diffraction analysis: T. Oda, et al.; Biophys. J. 88, 2727 (2005) Abstract
Further Categories Containing This Product:
Amanitins & Phalloidins / Related Products • Actin / Related Products
 
 
ALX-350-266 Revised 01-Jun-06
Phalloidin, Amino-, . hydrochloride
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cytoskeletal Research
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ALX-350-266-M001   1 mg 520.00 USD Add To Cart
Product Specification
FORMULA: C35H49N9O10S . HCl
MW: 787.9 . 36.5
SOURCE/HOST: Semisynthetic from phalloidin.
PURITY: ≥90% (HPLC)
APPEARANCE: Amorphous solid.
SOLUBILITY: Soluble in DMSO, dimethyl formamide, methanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from moisture.
HAZARD: VERY TOXIC.

Product Description
Biological activity like phalloidin (Prod. No. ALX-350-265), but contains a functional amino group for coupling reactions.
Further Categories Containing This Product:
Amanitins & Phalloidins / Related Products • Actin / Related Products
 
 
ALX-350-267 Revised 08-Apr-08
Phalloidin (Biotin)
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SYNONYMS Biotinyl-hexamethylenamidosuccinyl-aminomethyldithiolano-phalloidin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cytoskeletal Research
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ALX-350-267-MC01   0.1 mg 175.00 USD Add To Cart
Product Specification
FORMULA: C57H83N13O13S4
MW: 1286.6
SOURCE/HOST: Semisynthetic from aminomethyldithiolano-phalloidin.
PURITY: ≥90%
APPEARANCE: Amorphous solid.
SOLUBILITY: Soluble in DMSO, dimethyl formamide, methanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Prepare fresh solutions for each application.
HANDLING: Protect from light and moisture.
HAZARD: VERY TOXIC.

Product Description
Binds actin filaments and streptavidin simultaneously, due to the long spacer between the two active components.
Product Specific Literature References
Preparation of tetramethylrhodaminyl-phalloidin and uptake of the toxin into short-term cultured hepatocytes by endocytosis: H. Faulstich, et al.; Exp. Cell Res. 144, 73 (1983) Abstract
Biotinylphallotoxins: preparation and use as actin probes: H. Faulstich, et al.; J. Histochem. Cytochem. 37, 1035 (1989) Abstract
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Amanitins & Phalloidins / Related Products • Actin / Related Products • Biotinylated Reagents Other Products
 
 
ALX-350-268 Revised 01-Jun-06
Phalloidin (FITC)
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SYNONYMS Fluoresceinyl-aminomethyldithiolano-phalloidin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cytoskeletal Research
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ALX-350-268-MC01   0.1 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C58H62N10O14S4
MW: 1251.4
SOURCE/HOST: Semisynthetic from aminomethyldithiolano-phalloidin.
PURITY: ≥90%
APPEARANCE: Amorphous solid.
SOLUBILITY: Soluble in DMSO, dimethyl formamide, methanol or water (warm).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Prepare fresh solutions for each application.
HANDLING: Protect from light and moisture.
HAZARD: VERY TOXIC.

Product Description
For detection of microfilaments in the light microscope. Mixture of 4 isomers with lower affinity to actin than phalloidin (Prod. No. ALX-350-265).
Product Specific Literature References
Fluorescent phallotoxin, a tool for the visualization of cellular actin: E. Wulf, et al.; PNAS 76, 4498 (1979) Abstract
Fluorescent phallotoxins as probes for filamentous actin: H. Faulstich, et al.; J. Muscle Res. Cell Motil. 9, 370 (1988) Abstract
Further Categories Containing This Product:
Dyes / Stains / Fluorescent Probes / Fluorescent Labels • Amanitins & Phalloidins / Related Products • Actin / Related Products
 
 
ALX-350-269 Revised 16-Aug-07
Phallacidin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cytoskeletal Research
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ALX-350-269-M001   1 mg 130.00 USD Add To Cart
Product Specification
FORMULA: C37H50N8O13S
MW: 846.9
CAS NUMBER: 26645-35-2
SOURCE/HOST: Isolated from Amanita phalloides mushrooms.
PURITY: ≥90%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO, dimethyl formamide, methanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: VERY TOXIC.

Product Description
Biological activity like phalloidin (Prod. No. ALX-350-265), but contains a carboxy group for coupling reactions.
Product Specific Literature References
Fluorescence staining of the actin cytoskeleton in living cells with 7-nitrobenz-2-oxa-1,3-diazole-phallacidin: L.S. Barak, et al.; PNAS 77, 980 (1980) Abstract
Phallacidin prevents thrombin-induced increases in endothelial permeability to albumin: P.G. Phillips, et al.; Am. J. Physiol. 257, C562 (1989) Abstract
Further Categories Containing This Product:
Amanitins & Phalloidins / Related Products • Actin / Related Products
 
 
ALX-350-270 Revised 08-Feb-08
α-Amanitin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation / Transcription
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ALX-350-270-M001   1 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C39H54N10O14S
MW: 919.0
CAS NUMBER: 23109-05-9
MERCK INDEX: 14: 373
RTECS: BD6195000
SOURCE/HOST: Isolated from Amanita phalloides mushrooms.
PURITY: ≥90%
APPEARANCE: White to light yellow powder.
SOLUBILITY: Soluble in 100% ethanol (5mg/ml), DMSO, dimethyl formamide, methanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Dilute with buffer immediately prior to use. Product is destroyed by concentrated acid or base.
HANDLING: Protect from light.
HAZARD: VERY TOXIC.

Product Description
Inhibits eukaryotic RNA-polymerase II with high efficiency, but not eukaryotic RNA-polymerase I, or bacterial or viral RNA-polymerases. Inhibits mammalian protein synthesis.
Product Specific Literature References
Effect of alpha-amanitin on ribonucleic acid synthesis and on ribonucleic acid polymerase in mouse liver: F. Stirpe & L. Fiume; Biochem. J. 103, 67P (1967) Abstract
Specific inhibition of nuclear RNA polymerase II by alpha-amanitin: T.J. Lindell, et al.; Science 170, 447 (1970) Abstract
Fifty years of amanitin: T. Wieland & H. Faulstich; Experientia 47, 1189 (1991), (Review) Abstract
Alpha-amanitin blocks translocation by human RNA polymerase II: X.Q. Gong, et al.; J. Biol. Chem. 279, 27422 (2004) Abstract
Further Categories Containing This Product:
Amanitins & Phalloidins / Related Products • Protein Synthesis Other Products • RNA Polymerases / Related Products
 
 
ALX-350-271 Revised 08-Oct-07
β-Amanitin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation / Transcription
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ALX-350-271-M001   1 mg 170.00 USD Add To Cart
Product Specification
FORMULA: C39H53N9O15S
MW: 920.0
CAS NUMBER: 21150-22-1
MERCK INDEX: 14: 373
SOURCE/HOST: Isolated from Amanita phalloides mushrooms.
PURITY: ≥90%
FORMULATION: White to off-white powder.
SOLUBILITY: Soluble in DMSO, dimethyl formamide, methanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Dilute with buffer immediately prior to use. Product is destroyed by concentrated acid or base.
HANDLING: Protect from light.
HAZARD: VERY TOXIC.

Product Description
Biological activity like α-amanitin (Prod. No. ALX-350-270), but contains a carboxy group which is useful for coupling reactions.
Further Categories Containing This Product:
Amanitins & Phalloidins / Related Products • Protein Synthesis Other Products • RNA Polymerases / Related Products
 
 
ALX-350-272 Revised 17-Dec-07
γ-Amanitin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation / Transcription
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ALX-350-272-M001   1 mg 170.00 USD Add To Cart
Product Specification
FORMULA: C39H54N10O13S
MW: 903.0
CAS NUMBER: 13567-11-8; 21150-23-2
MERCK INDEX: 14: 373
SOURCE/HOST: Isolated from Amanita phalloides mushrooms.
PURITY: ≥90%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO, dimethyl formamide or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Dilute with buffer immediately prior to use. Product is destroyed by concentrated acid or base.
HANDLING: Protect from light.
HAZARD: VERY TOXIC.

Product Description
Biological activity like α-amanitin (Prod. No. ALX-350-270).
Further Categories Containing This Product:
Amanitins & Phalloidins / Related Products • Protein Synthesis Other Products • RNA Polymerases / Related Products
 
 
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