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Natural Products / Antibiotics
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ALX-350-349 Revised 08-Apr-08
Herbimycin C
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SYNONYMS Antibiotic TAN 420D
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-350-349-MC05   0.5 mg 330.00 USD Add To Cart
Product Specification
FORMULA: C29H40N2O9
MW: 560.6
CAS NUMBER: 91700-92-4
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS5386.
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in 100% ethanol,  methanol, dimethyl formamide or DMSO; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description

Antibiotic. Minor analog of the herbimycin complex with potent antitumor activity. Converts Rous sarcoma virus-infected rat kidney cells into normal cells.
Product Specific Literature References
The structure and cytocidal activity of herbimycin C: K. Shibata, et al.; J. Antibiot. 39, 1630 (1986) Abstract
1H-nmr analysis of herbimycins and dihydro-herbimycins: L.Z. Lin, et al.; J. Nat. Prod. 51, 1161 (1988) Abstract
 
 
ALX-385-011 Revised 05-Apr-08
(±)-Hesperetin
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SYNONYMS (±)-3',5,7-Trihydroxy-4'-methoxyflavanone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonoids/Related Products
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ALX-385-011-G001   1 g 21.00 USD Add To Cart
Product Specification
FORMULA: C16H14O6
MW: 302.3
CAS NUMBER: 520-33-2
MERCK INDEX: 14: 4670
PURITY: ≥95% (HPLC)
APPEARANCE: Off-white to yellow powder.
SOLUBILITY: Soluble in 100% ethanol; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Antioxidant flavonoid. Induces G1-phase cell cycle arrest. Anti-inflammatory. Suppresses NF-κB activation. Reduces cholesterol biosynthesis. Inhibits lipid peroxidation. Neuroprotective against neuronal oxidative damage.
Product Specific Literature References
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Lipid-lowering efficacy of hesperetin metabolites in high-cholesterol fed rats: H. K. Kim, et al.; Clin. Chim. Acta 327, 129 (2003) Abstract
Antioxidant and neuroprotective effects of hesperidin and its aglycone hesperetin: J. Cho; Arch. Pharm. Res. 29, 699 (2006) Abstract
Modulation of the age-related nuclear factor-kappaB (NF-kappaB) pathway by hesperetin: J. Y. Kim, et al.; Aging Cell 5, 401 (2006) Abstract
Hesperetin Induced G1-Phase Cell Cycle Arrest in Human Breast Cancer MCF-7 Cells: Involvement of CDK4 and p21: E.J. Choi; Nutr. Cancer 59, 115 (2007) Abstract
Further Categories Containing This Product:
NF-kB Pathway Inhibitors • Active Substances from Fruit and Vegetables • Natural Products - NF-kB Pathway Inhibitors • Natural Products - Anti-inflammatory Agents • Natural Products - Antioxidants
 
 
ALX-380-123 Revised 20-Dec-07
Hexacyclinic acid
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-380-123-M001   1 mg 90.00 USD Add To Cart
ALX-380-123-M005   5 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C26H34O9
MW: 490.6
SOURCE/HOST: Isolated from Streptomyces cellulosae ssp. griseorubinosus
PURITY: ≥98% (HPLC)
APPEARANCE: White to pale pink solid.
SOLUBILITY: Soluble in DMSO, methanol or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Antitumor antibiotic. Displays weak cytotoxicity against different tumor cell lines.
Product Specific Literature References
Hexacyclinic acid, a Polyketide from Streptomyces with a Novel Carbon Skeleton: R. Hofs, et al.; Angew. Chem. Int. Ed. Engl. 39, 3258 (2000) Abstract
 
 
ALX-350-138 Revised 05-Dec-06
Hexaprenylhydroquinone
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SYNONYMS HPH
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antiviral/anti-HIV Agents
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ALX-350-138-M001   1 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C36H54O2
MW: 518.8
CAS NUMBER: 119980-00-6
SOURCE/HOST: Isolated from Sarcotragus sp.
PURITY: ≥97% (HPLC)
APPEARANCE: Off-white to brown solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by MS, 1H-NMR.

Product Description
Potent inhibitor of HIV reverse transcriptase and cellular DNA polymerase. Inhibitor of CDC25A. Similar compounds have shown inhibitory effects on phospholipase A2.
Product Specific Literature References
Three new heptaprenylhydroquinone derivatives from the sponge Ircinia fasciculata: Y. Venkateswarlu and M. Venkata Rami Reddy; J. Nat. Prod. 57, 1286 (1994)
Biological effects of prenylated hydroquinones: structure-activity relationship studies in antimicrobial, brine shrimp, and fish lethality assays: S. De Rosa, et al.; J. Nat. Prod. 57, 1711 (1994) Abstract
Mode of inhibition of HIV reverse transcriptase by 2-hexaprenylhydroquinone, a novel general inhibitor of RNA-and DNA-directed DNA polymerases: S. Loya, et al.; Biochem. J. 324, 721 (1997) Abstract; Full Text
Polyprenyl-hydroquinones and -furans from three marine sponges inhibit the cell cycle regulating phosphatase CDC25A: I. Erdogan-Orhan, et al.; Nat. Prod. Res. 18, 1 (2004) Abstract
General Literature References
Effects of marine 2-polyprenyl-1,4-hydroquinones on phospholipase A2 activity and some inflammatory responses: B. Gil, et al.; Eur. J. Pharmacol. 285, 281 (1995) Abstract
Further Categories Containing This Product:
PLA2 Inhibitors • Natural Products - DNA Replication Inhibitors • HIV/AIDS/Related Products
 
 
ALX-550-061 Revised 18-Mar-08
(+)-Himbacine
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SYNONYMS (3S,3aR,4R,4aS,8aR,9aS)-4-[(1E)-2-[(2R,6S)-1,6-Dimethyl-2-piperdinyl]ethenyl]decahydro-3-methyl-naphtho[2,3-c]furan-1(3H)-one
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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ALX-550-061-M001   1 mg 40.00 USD Add To Cart
ALX-550-061-M005   5 mg 160.00 USD Add To Cart
ALX-550-061-M025   25 mg 520.00 USD Add To Cart
Product Specification
FORMULA: C22H35NO2
MW: 345.5
CAS NUMBER: 6879-74-9
RTECS: QL0843500
SOURCE/HOST: Isolated from the Australian pine Galbulimima baccata.
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in methanol, 100% ethanol or methylene chloride; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Hygroscopic.

Product Description
Potent muscarinic antagonist that displays selectivity for the M2 or M4 receptors.
Product Specific Literature References
Binding and functional selectivity of himbacine for cloned and neuronal muscarinic receptors: J.H. Miller, et al.; Pharmacol. Exp. Ther. 263, 663 (1992) Abstract
Structural basis of the subtype selectivity of muscarinic antagonists: a study with chimeric m2/m5 muscarinic receptors: J. Wess, et al.; Mol. Pharmacol. 41, 369 (1992) Abstract
Simplified analogs of himbacine displaying potent binding affinity for muscarinic receptors: M.J. Malaska, et al.; Bioorg. Med. Chem. Lett. 3, 1247 (1993)
Chemical modification of ring C of himbacine: discovery of a pharmacophoric element for M2-selectivity: M.J. Malaska, et al.; Bioorg. Med. Chem. Lett. 5, 61 (1995)
Total Syntheses of (+)-Himbacine and (+)-Himbeline: D.J. Hart, et al.; JACS 117, 9369 (1995)
Design, synthesis, and structure-activity relationship studies of himbacine derived muscarinic receptor antagonists: D. Doller, et al.; Bioorg. Med. Chem. Lett. 9, 901 (1999) Abstract
Himbacine analogs as muscarinic receptor antagonists--effects of tether and heterocyclic variations: S. Chackalamannil, et al.; Bioorg. Med. Chem. Lett. 14, 3967 (2004) Abstract
Further Categories Containing This Product:
Acetylcholine Receptors (Muscarinic)/Related Products • Alkaloids
 
 
ALX-350-236 Revised 30-Oct-07
Homoharringtonine
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Immunomodulators
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ALX-350-236-M001   1 mg 45.00 USD Add To Cart
ALX-350-236-M005   5 mg 170.00 USD Add To Cart
Product Specification
FORMULA: C29H39NO9
MW: 545.6
CAS NUMBER: 26833-87-4
SOURCE/HOST: Isolated from Cephalotaxus hainanensis.
PURITY: ≥96%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Cephalotaxine alkaloid. Inhibits the formation of diphenylalanine and acetylphenylalanyl-puromycin in liver ribosomes. Has promising activity in hematologic malignancies. Lowers the levels of telomerase. Induces apoptosis.
Product Specific Literature References
Different effects of L-histidinol and homoharringtonine on 5- fluorouracil and bis-chloroethylnitrosourea activity in a murine model: R.C. Warrington & W.D. Fang; Anticancer Res. 11, 1879 (1991) Abstract
Selective inhibition of the polypeptide chain elongation in eukaryotic cells: R.M. Tujebajeva, et al.; Biochim. Biophys. Acta 1129, 177 (1992) Abstract
Homoharringtonine is safe and effective for patients with acute myelogenous leukemia: E. Feldman, et al.; Leukemia 6, 1185 (1992) Abstract
Homoharringtonine: history, current research, and future direction: H.M. Kantarjian, et al.; Cancer 92, 1591 (2001), Review Abstract
Homoharringtonine: a new treatment option for myeloid leukemia: C.Y. Luo, et al.; Hematology 9, 259 (2004), Review Abstract
Homoharringtonine-induced apoptosis of human leukemia HL-60 cells is associated with down-regulation of telomerase: W.Z. Xie, et al.; Am. J. Chin. Med. 34, 233 (2006) Abstract
Further Categories Containing This Product:
Telomerase/Related Products • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Antitumor Reagents • Alkaloids
 
 
ALX-350-350 Revised 21-Aug-08
Honokiol
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SYNONYMS 5,3’-Diallyl-2,4’-biphenyldiol
5,3’-Diallyl-2,4’-dihydroxydiphenyl
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Angiogenesis Research
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ALX-350-350-M005   5 mg 40.00 USD Add To Cart
ALX-350-350-M025   25 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C18H18O2
MW: 266.3
CAS NUMBER: 35354-74-6
MERCK INDEX: 14: 4742
SOURCE/HOST: Isolated from Magnolia officinalis.
PURITY: ≥98% (HPLC)
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: IRRITANT.

Product Description
Potent and highly tolerable antitumor and antiangiogenic compound. Anxiolytic, anti-thrombotic and antibacterial. Shows central depressant effects in vivo. Inhibitor of nitric oxide (NO) and TNF-α production in LPS-activated macrophages by the suppression of inducible nitric oxide synthase (iNOS; NOS II) expression (IC50=6.4µM). Isomeric with magnolol (Prod. No. ALX-350-352). Inhibits NF-κB activation. Potent scavenger of superoxide and peroxyl radicals.
Product Specific Literature References
Pharmacological properties of Magnolol and Honokiol extracted from Magnolia officinalis: Central depressant effects: K. Watanabe, et al.; Planta Med. 49, 103 (1983) Abstract
Identification of magnolol and honokiol as anxiolytic agents in extracts of saiboku-to, an oriental herbal medicine: Y. Maruyama, et al.; J. Nat. Prod. 61, 135 (1998) Abstract
Inhibitors of nitric oxide synthesis and TNF-alpha expression from Magnolia obovata in activated macrophages: H.J. Son, et al.; Planta Med. 66, 469 (2000) Abstract
Down-modulation of Bcl-XL, release of cytochrome c and sequential activation of caspases during honokiol-induced apoptosis in human squamous lung cancer CH27 cells: S.E. Yang, et al.; Biochem. Pharmacol. 63, 1641 (2002) Abstract
Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo: X. Bai, et al.; J. Biol. Chem. 278, 35501 (2003) Abstract; Full Text
Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway: K.S. Ahn, et al.; Mol. Cancer Res. 4, 621 (2006) Abstract; Full Text
Magnolol and honokiol: inhibitors against mouse passive cutaneous anaphylaxis reaction and scratching behaviors: S.J. Han, et al.; Biol. Pharm. Bull. 30, 2201 (2007) Abstract; Full Text
Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression: B.H. Kim & J.Y. Cho; Acta Pharmacol. Sin. 29, 113 (2008) Abstract
Honokiol is a potent scavenger of superoxide and peroxyl radicals: S. Dikalov, et al.; Biochem. Pharmacol. 76, 589 (2008) Abstract
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Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity) • Natural Products - Nitric Oxide Pathway Modulators • Natural Products - Antitumor Reagents • Anxiolytic Agents/Related Products • Natural Products with Antibiotic Activity • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products for Neurological Research • Natural Products - Antifungal Agents
 
 
ALX-630-113 Revised 13-Jun-08
HT-2 Toxin
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SYNONYMS 15-Acetoxy-3α,4β-dihydroxy-8α-(3-methylbutyryloxy)-12,13-epoxytrichothec-9-ene
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Mycotoxins
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ALX-630-113-M001   1 mg 110.00 USD Add To Cart
ALX-630-113-M005   5 mg 440.00 USD Add To Cart
Product Specification
FORMULA: C22H32O8
MW: 424.5
CAS NUMBER: 26934-87-2
RTECS: YD0050000
SOURCE/HOST: Semisynthetic, derived from T2 toxin from Fusarium tricinctum.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in 100% ethanol, DMSO or ethyl acetate; poorly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: VERY TOXIC.

Product Description

Trichothecene group mycotoxin. Induces apoptosis
Product Specific Literature References
Structure-function relationship of T-2 toxin and its metabolites in inducing thymic apoptosis in vivo in mice: Z. Islam, et al.; Biosci. Biotechnol. Biochem. 62, 1492 (1998) Abstract; Full Text
Mechanisms involved in the induction of apoptosis by T-2 and HT-2 toxins in HL-60 human promyelocytic leukemia cells: J.A. Holme, et al.; Cell Biol. Toxicol. 19, 53 (2003) Abstract
A practical method for measuring deoxynivalenol, nivalenol, and T-2 + HT-2 toxin in foods by an enzyme-linked immunosorbent assay using monoclonal antibodies: T. Yoshizawa, et al.; Biosci. Biotechnol. Biochem. 68, 2076 (2004) Abstract; Full Text
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Further Categories Containing This Product:
Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-550-065 Revised 16-Jun-08
(-)-Huperzine A
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SYNONYMS (-)-Selagine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Cholinergics/Related Products
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ALX-550-065-MC05   0.5 mg 60.00 USD Add To Cart
ALX-550-065-M001   1 mg 100.00 USD Add To Cart
Product Specification
FORMULA: C15H18N2O
MW: 242.3
CAS NUMBER: 102518-79-6
MERCK INDEX: 14: 4755
SOURCE/HOST: Isolated from Lycopodium sp.
PURITY: ≥95%
APPEARANCE: White solid.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: NEUROTOXIN.

Product Description
Plant alkaloid. Active isomer with acetylcholine esterase activity. Protects cells against hydrogen peroxide, β-amyloid, glutamate, ischemia and staurosporine-induced cytotoxicity and apoptosis. Prospective agent for the treatment of Alzheimer‘s disease. For the racemic modification, see (±)-Huperzine A (Prod. No. ALX-550-064).
Product Specific Literature References
The effect of the nucleoside transport inhibitor dipyridamole on the incorporation of [3H]thymidine in the rat: J.-S. Liu, et al.; Can. J. Chem. 64, 837 (1986)
Effect of huperzine A, a new cholinesterase inhibitor, on the central cholinergic system of the rat: X.C. Tang, et al.; J. Neurosci. Res. 24, 276 (1989) Abstract
A Practical Synthesis of the Chinese "Nootropic" Agent Huperzine A: A Possible Lead in the Treatment of Alzheimer's Disease: Y. Xia & A.P. Kozikowski; JACS 111, 4116 (1989)
Synthesis and Biological Evaluation of (±)-Z-Huperzine A: A.P. Kozikowski, et al.; Tetrahedron Lett. 31, 6159 (1990)
Potencies and stereoselectivities of enantiomers of huperzine A for inhibition of rat cortical acetylcholinesterase: M. McKinney, et al.; Eur. J. Pharmacol. 203, 303 (1991) Abstract
Mechanism of inhibition of cholinesterases by huperzine A: Y. Ashani; BBRC 184, 719 (1992) Abstract
Natural and synthetic Huperzine A: effect on cholinergic function in vitro and in vivo: I. Hanin, et al.; Ann. N. Y. Acad. Sci. 695, 304 (1993) Abstract
An Improved Synthetic Route to Huperzine A; New Analogues and Their Inhibition of Acetylcholinesterase: A.P. Kozikowski, et al.; J. C. S. Chem. Commun. 860 (1993)
Huperzine A, a potential therapeutic agent for treatment of Alzheimer’s disease: D.L. Bai, et al.; Curr. Med. Chem. 7, 355 (2000), (Review) Abstract
Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine: R. Wang, et al.; Acta Pharmacol. Sin. 27, 1 (2006), (Review) Abstract
Further Categories Containing This Product:
Acetylcholine Esterase/Related Products • Natural Products for Neurological Research • Alzheimer Research Other Products