© 2008 Alexis Corporation
You are here:
Product Lines
>
Natural Products / Antibiotics
>
Natural Products
> Alkaloids
ALX-350-104
Revised 10-May-07
Aaptamine
SYNONYMS
8,9-Dimethoxy-1
H
-benzo[
de
][1,6]naphtyridine
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Toxins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-104-M001
1 mg
90.00 USD
Product Specification
FORMULA:
C
13
H
12
N
2
O
2
MW:
228.3
CAS NUMBER:
85547-22-4
SOURCE/HOST:
Isolated from the sponge
Aaptos aaptos
.
PURITY:
≥97%
APPEARANCE:
Oil.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
Product Description
Competitive antagonist of α-adrenoceptors in vascular smooth muscle cells. Inhibits cancer cell growth.
Product Specific Literature References
Alpha-adrenoceptor blocking action of aaptamine, a novel marine natural product, in vascular smooth muscle
:
Y. Ohizumi, et al.; J. Pharm. Pharmacol.
36
, 785 (1984)
Abstract
Antineoplastic agents 491. Synthetic conversion of aaptamine to isoaaptamine, 9-demethylaaptamine, and 4-methylaaptamine:
G.R. Pettit, et al.; J. Org. Chem.
69
, 2251 (2004)
Abstract
Aaptamine, a spongean alkaloid, activates p21 promoter in a p53-independent manner:
S. Aoki, et al.; BBRC
342
, 101 (2006)
Abstract
Further Categories Containing This Product:
Alkaloids
•
Antitumor Agents (Anti-proliferative)
•
Adrenergics & Adrenergic Receptors/Related Products
•
Natural Products - Antitumor Reagents
ALX-550-232
Revised 13-May-08
Aconitine
SYNONYMS
(1α,3α,6α,14α,15α,16β)-20-Ethyl-1,6,16-trimethoxy-4-(methoxymethyl)aconitane-3,8,13,14,15-pentol 8-acetate 14-benzoate
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Neurotoxins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-550-232-M025
25 mg
45.00 USD
Product Specification
FORMULA:
C
34
H
47
NO
11
MW:
645.7
CAS NUMBER:
302-27-2
MERCK INDEX:
14:
118
RTECS:
AR5960000
SOURCE/HOST:
Isolated from
Aconitum karacolium
.
PURITY:
≥98%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in 100% ethanol (35mg/ml); almost insoluble in water (0.3mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
HAZARD:
VERY TOXIC.
Product Description
A lipid-soluble neurotoxin that acts as a sodium channel modulator. Blocks tetrodotoxin-sensitive Na
+
channels. Potent neurotoxin.
Product Specific Literature References
Non-quantal acetylcholine release at mouse neuromuscular junction: effects of elevated quantal release and aconitine:
S.P. Yu & W. Van der Kloot; Neurosci. Lett.
117
, 111 (1990)
Abstract
Synthesis and activity of a potent N-methyl-D-aspartic acid agonist, trans-1-aminocyclobutane-1,3-dicarboxylic acid, and related phosphonic and carboxylic acids:
M. Muroi, et al.; Neuropharmacology
29
, 567 (1990)
Abstract
Further Categories Containing This Product:
Alkaloids
•
Na+ Channels
ALX-350-156
Revised 18-Feb-08
Aerophobin-2
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Alkaloids
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-156-M001
1 mg
160.00 USD
Product Specification
FORMULA:
C
16
H
19
Br
2
N
5
O
4
MW:
505.2
CAS NUMBER:
87075-23-8
SOURCE/HOST:
Isolated from
Aplysina aerophoba
.
PURITY:
≥97% (HPLC)
APPEARANCE:
White to off-white amorphous solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
IDENTITY:
Identity determined by
1
H-NMR.
Product Description
Cytotoxic alkaloid. Shows antibiotic properties.
Product Specific Literature References
The bromo-compounds of the true sponge Verongia aerophoba:
G. Cimino, et al.; Tetrahedron Lett.
24
, 3029 (1983)
Antibiotic and cytotoxic activity of brominated compounds from the marine sponge Verongia aerophoba:
R. Teeyapant, et al.; Z. Naturforsch.
48
, 939 (1993)
Abstract
Approaches to the synthesis of some tyrosine-derived marine sponge metabolites: synthesis of verongamine and purealidin N:
T.R. Boehlow, et al.; J.Org. Chem.
66
, 3111 (2001)
Abstract
Two unprecedented dibromotyrosine-derived alkaloids from the Brazilian endemic marine sponge Aplysina caissara:
B.M. Saeki, et al.; J. Nat. Prod.
65
, 796 (2002)
Abstract
Chemical defense of Mediterranean sponges Aplysina cavernicola and Aplysina aerophoba:
C. Thoms, et al.; Z. Naturforsch.
59
, 113 (2004)
Abstract
Further Categories Containing This Product:
Natural Products with Antibiotic Activity
ALX-350-326
Revised 29-May-07
Agelongine
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Neurological Research
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-326-M001
1 mg
160.00 USD
Product Specification
FORMULA:
C
13
H
11
BrN
2
O
4
MW:
339.1
CAS NUMBER:
163564-84-9
SOURCE/HOST:
Isolated from the sponge
Agelas longissima
.
PURITY:
≥97% (HPLC)
APPEARANCE:
Yellow to brown solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
IDENTITY:
Identity determined by
1
H-NMR,
13
C-NMR and MS.
Product Description
Alkaloid exhibiting antagonistic activity on serotonin receptors.
Product Specific Literature References
A novel bromopyrrole alkaloid from the sponge agelas longissima with antiserotonergic activity:
F. Cafieri, et al.; Bioorg. Med. Chem. Lett.
5
, 799 (1995)
Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent:
L. Meijer, et al.; Chem. Biol.
7
, 51 (2000)
Abstract
Further Categories Containing This Product:
Alkaloids
•
Serotonergics & Serotonin Receptors/Related Products
ALX-350-112
Revised 29-Nov-07
Anabasine . hydrochloride
SYNONYMS
3-(2-Piperidinyl)pyridine
2-(3-Pyridyl)piperidine
Neonicotine
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Neurological Research
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-112-M025
25 mg
20.00 USD
ALX-350-112-M100
100 mg
60.00 USD
Product Specification
FORMULA:
C
10
H
14
N
2
. HCl
MW:
162.2 . 36.5
CAS NUMBER:
15251-47-5
MERCK INDEX:
14:
619
SOURCE/HOST:
Isolated from
Anabasis aphylla.
PURITY:
≥97%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in alcohol or water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
Product Description
Tobacco alkaloid. Potent nicotinic acetylcholine receptor agonist. Insecticide.
Product Specific Literature References
Nicotine, cotinine, and anabasine inhibit aromatase in human trophoblast in vitro:
R.L. Barbieri, et al.; J. Clin. Invest.
77
, 1727 (1986)
Abstract
Anabasine and anatabine as biomarkers for tobacco use during nicotine replacement therapy:
P. Jacob, 3rd, et al.; Cancer Epidemiol. Biomarkers Prev.
11
, 1668 (2002)
Abstract
Anabasine, a selective nicotinic acetylcholine receptor agonist, antagonizes MK-801-elicited mouse popping behavior, an animal model of schizophrenia:
J. Mastropaolo, et al.; Behav. Brain Res.
153
, 419 (2004)
Abstract
Simultaneous and sensitive measurement of anabasine, nicotine, and nicotine metabolites in human urine by liquid chromatography-tandem mass spectrometry:
X. Xu, et al.; Clin. Chem.
50
, 2323 (2004)
Abstract
Anabasine toxicity from a topical folk remedy:
N.G. Murphy, et al.; Clin. Pediatr. (Phila)
45
, 669 (2006)
Abstract
Further Categories Containing This Product:
Acetylcholine Receptors (Nicotinic)/Related Products
•
Alkaloids
•
Pesticides/Related Products
ALX-270-047
Revised 26-Sep-07
Aristolochic acid
SYNONYMS
8-Methoxy-6-nitrophenanthrol(3,4-d)-1,3-dioxide-5-carboxylic acid
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Other Signal Transduction Pathway Modulators
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-047-M025
25 mg
25.00 USD
ALX-270-047-M100
100 mg
90.00 USD
Product Specification
FORMULA:
C
17
H
11
NO
7
MW:
341.3
CAS NUMBER:
313-67-7
MERCK INDEX:
14:
786
RTECS:
CF3325000
SOURCE/HOST:
Isolated from
Aristolochia clematis
.
PURITY:
≥97% (~1:1 mixture of aristolochic acids I (A) and II (B))
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HAZARD:
MAY BE CARCINOGENIC. TOXIC. MAY BE MUTAGENIC.
Product Description
Phospholipase A
2
(PLA
2
) inhibitor active against the enzymes found in many snake venoms as well as those of human platelets and synovial fluids. Inhibits ionophore-stimulated PLA
2
activity in human neutrophils. Has been shown to be nephropathic and carcinogenic.
Product Specific Literature References
Characterization of three edema-inducing phospholipase A2 enzymes from habu (Trimeresurus flavoviridis) venom and their interaction with the alkaloid aristolochic acid:
B.S. Vishwanath, et al.; Toxicon
25
, 501 (1987)
Abstract
Interaction of aristolochic acid with Vipera russelli phospholipase A2: its effect on enzymatic and pathological activities:
B.S. Vishwanath & T.V. Gowda; Toxicon
25
, 929 (1987)
Abstract
Interaction of phospholipase A2 from Vipera russelli venom with aristolochic acid: a circular dichroism study:
B.S. Vishwanath, et al.; Toxicon
25
, 939 (1987)
Abstract
Edema-inducing activity of phospholipase A2 purified from human synovial fluid and inhibition by aristolochic acid:
B.S. Vishwanath, et al.; Inflammation
12
, 549 (1988)
Abstract
Effects of aristolochic acid on phospholipase A2 activity and arachidonate metabolism of human neutrophils:
M.D. Rosenthal, et al.; Biochim. Biophys. Acta
1001
, 3 (1989)
Abstract
Suramin alters phosphoinositide synthesis and inhibits growth factor receptor binding in HT-29 cells:
R. Kopp & A. Pfeiffer; Cancer Res.
50
, 6490 (1990)
Abstract
The effects of the phospholipase A2 inhibitors aristolochic acid and PGBx on A23187-stimulated mobilization of arachidonate in human neutrophils are overcome by diacylglycerol or phorbol ester:
M.D. Rosenthal, et al.; Biochim. Biophys. Acta
1126
, 319 (1992)
Abstract
Evidence for different mechanisms involved in the formation of lyso platelet-activating factor and the calcium-dependent release of arachidonic acid from human neutrophils:
J.D. Winkler, et al.; Biochem. Pharmacol.
44
, 2055 (1992)
Abstract
Selective inhibition of group II phospholipase A2 by quercetin:
M. Lindahl & C. Tagesson; Inflammation
17
, 573 (1993)
Abstract
Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy:
H.H. Schmeiser, et al.; Cancer Res.
56
, 2025 (1996)
Abstract
Aristolochic acid and ’Chinese herbs nephropathy’: a review of the evidence to date:
J.P. Cosyns; Drug Saf.
26
, 33 (2003), Review
Abstract
Effect of aristolochic acid on intracellular calcium concentration and its links with apoptosis in renal tubular cells:
Y.H. Hsin, et al.; Apoptosis
11
, 2167 (2006)
Abstract
Further Categories Containing This Product:
PLA2 Inhibitors
•
Carcinogens & Tumor Promoters Other Products
•
Natural Products - Other Tumor Promoters
•
Alkaloids
•
Other Toxins
ALX-270-157
Revised 03-Apr-08
Australine . hydrochloride
SYNONYMS
(1R,2R,3R,7S,7aR)-3-Hydroxymethyl-1,2,7-trihydroxypyrrolizidine . HCI
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Other Signal Transduction Pathway Modulators
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-157-M001
1 mg
180.00 USD
Product Specification
FORMULA:
C
8
H
15
NO
4
. HCl
MW:
189.2 . 36.5
CAS NUMBER:
186766-07-4
SOURCE/HOST:
Isolated from
Castanospermum australe
seeds.
PURITY:
≥95%
APPEARANCE:
Crystalline solid.
SOLUBILITY:
Soluble in water, methanol and 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
After reconstitution, prepare aliquots and store at -20°C.
HAZARD:
HARMFUL.
Product Description
Alkaloid. Inhibitor of α-glucosidase, amyloglucosidase and glucosidase I. Does not inhibit glucosidase II, and is reported to be the first glucosidase inhibitor which differentiates glucosidase I from glucosidase II. Does not inhibit α-galactosidase, β-galactosidase, β-glucosidase, α-mannosidase and β-mannosidase.
Product Specific Literature References
Australine, a pyrrolizidine alkaloid that inhibits amyloglucosidase and glycoprotein processing:
J.E. Tropea, et al.; Biochemistry
28
, 2027 (1989)
Abstract
Calystegins, a novel class of alkaloid glycosidase inhibitors:
R.J. Molyneux, et al.; Arch. Biochem. Biophys.
304
, 81 (1993)
Abstract
Stereoselective synthesis of the glycosidase inhibitor australine through a one-pot, double-cyclization strategy:
C. Ribes, et al.; Org. Lett.
9
, 77 (2007)
Abstract
Further Categories Containing This Product:
Alkaloids
•
Glycosidases/Related Products
ALX-350-094
Revised 24-Jul-08
Berberine . hemisulfate
SYNONYMS
Natural Yellow 18
5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products with Antibiotic Activity
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-094-G001
1 g
15.00 USD
Product Specification
FORMULA:
C
20
H
18
NO
4
. 0.5SO
4
MW:
336.4 . 48.0
CAS NUMBER:
633-66-9
MERCK INDEX:
14:
1154
RTECS:
DR9867000
PURITY:
≥98% (TLC)
APPEARANCE:
Off-white to yellow powder.
SOLUBILITY:
50mg/ml soluble in methanol:water 2:1.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HAZARD:
TOXIC.
IDENTITY:
Determined by IR: Identical to standard reference.
Product Description
Alkaloid which exhibits relatively weak antibiotic properties, because of its efflux by multidrug resistance pumps. The antimicrobial action of berberine is potentiated by 5’-methoxyhydnocarpin, a multidrug pump inhibitor. Lowers cholesterol levels through a mechanism different from that of statins. Upregulates the expression of liver low-density lipoprotein receptor (LDLR) resulting in improved clearance of plasma LDL cholesterol through receptor mediated endocytosis. Possesses anti-inflammatory, anti-diabetic and anti-angiogenic effects. Induces apoptosis.
Product Specific Literature References
Berberine sulfate: antimicrobial activity, bioassay, and mode of action:
A.H. Amin, et al.; Can. J. Microbiol.
15
, 1067 (1969)
Abstract
Bacteria lacking a multidrug pump: a sensitive tool for drug discovery:
P.C. Hsieh, et al.; PNAS
95
, 6602 (1998)
Abstract
;
Full Text
Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5’-methoxyhydnocarpin, a multidrug pump inhibitor:
F.R. Stermitz, et al.; PNAS
97
, 1433 (2000)
Abstract
;
Full Text
Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins:
W. Kong, et al.; Nat. Med.
10
, 1344 (2004)
Abstract
The anti-inflammatory potential of berberine in vitro and in vivo:
C.L. Kuo, et al.; Cancer Lett.
203
, 127 (2004)
Abstract
Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion:
S.H. Leng, et al.; Acta Pharmacol. Sin.
25
, 496 (2004)
Abstract
Berberine inhibits HIF-1alpha expression via enhanced proteolysis:
S. Lin, et al.; Mol. Pharmacol.
66
, 612 (2004)
Abstract
Apoptosis of human leukemia HL-60 cells and murine leukemia WEHI-3 cells induced by berberine through the activation of caspase-3:
C.C. Lin, et al.; Anticancer Res.
26
, 227 (2006)
Abstract
Berberine acutely inhibits insulin secretion from beta cells through cAMP signaling pathway:
L. Zhou, et al.; Endocrinology (2008)
Abstract
Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis.:
M.K. Pandey, et al.; Cancer Res.
68
, 5370 (2008)
Abstract
Further Categories Containing This Product:
Natural Products - Anti-inflammatory Agents
•
Alkaloids
•
Natural Products - Chemopreventive Agents
•
Antidiabetic Agents/Related Products
•
Cholesterol & Lipid Transport/Related Products
ALX-550-322
Revised 29-Oct-07
Caffeine
SYNONYMS
1,3,7-Trimethylxanthine
3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Neurological Research
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-550-322-G005
5 g
10.00 USD
Product Specification
FORMULA:
C
8
H
10
N
4
O
2
MW:
194.2
CAS NUMBER:
58-08-2
MERCK INDEX:
14:
1636
SOURCE/HOST:
Found in tea leaves, coffee beans, cocoa beans, maté leaves, guarana paste and kola nuts.
PURITY:
≥99%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in chloroform, 100% alcohol or hot water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HAZARD:
TOXIC.
Product Description
CNS stimulant. Blocks adenosine A1 and A2A receptors. cAMP phosphodiesterase inhibitor. Interferes with the uptake and storage of Ca2+ by the sarcoplasmic reticulum in skeletal muscle. Prevents apoptosis and cell cycle effects induced by various chemicals. Inhibits cellular DNA repair mechanisms. Anti-inflammatory.
Product Specific Literature References
Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors:
J.W. Daly, et al.; J. Med. Chem.
29
, 1305 (1986)
Abstract
Caffeine as an analgesic adjuvant: a review of pharmacology and mechanisms of action:
J. Sawynok & T.L. Yaksh; Pharmacol. Rev.
45
, 43 (1993)
Abstract
Caffeine prevents apoptosis and cell cycle effects induced by camptothecin or topotecan in HL-60 cells:
F. Traganos, et al.; Cancer Res.
53
, 4613 (1993)
Abstract
Multiple effects of caffeine on calcium current in rat ventricular myocytes:
I. Zahradnik & P. Palade; Pfluegers Arch.
424
, 129 (1993)
Abstract
Acute effects of caffeine on arterial stiffness, wave reflections, and central aortic pressures:
T.G. Papaioannou, et al.; Am. J. Hypertens.
18
, 129 (2005), (Review)
Abstract
Caffeine and the dopaminergic system:
O. Cauli & M. Morelli; Behav. Pharmacol.
16
, 63 (2005), (Review)
Abstract
Immunomodulatory effects of caffeine: friend or foe:
L. A. Horrigan, et al.; Pharmacol. Ther.
111
, 877 (2006), (Review)
Abstract
Novel neuroprotection by caffeine and adenosine A(2A) receptor antagonists in animal models of Parkinson’s disease:
A. Kalda, et al.; J. Neurol. Sci.
248
, 9 (2006), (Review)
Abstract
The enigmatic effects of caffeine in cell cycle and cancer:
A. M. & Bode and Z. Dong; Cancer Lett.
247
, 26 (2007), (Review)
Abstract
Further Categories Containing This Product:
Ca2+ Modulators
•
Natural Products - Other Signal Transduction Pathway Modulators
•
Phosphodiesterases/Related Products
•
DNA Repair Other Products
•
Neuroactive Agents Other Products
•
Natural Products - Apoptosis Inducers & Inhibitors
•
Natural Products for Cell Cycle Research
•
Natural Products - Anti-inflammatory Agents
•
Natural Products - Chemopreventive Agents
•
Alkaloids
•
Active Substances from Fruit and Vegetables
•
Other Natural Products - DNA Regulation/Transcription
ALX-350-314
Revised 20-Dec-07
(+)-Calystegine B2
SYNONYMS
(1R,2S,3R,4S,5R)-8-Azabicyclo[3.2.1]octane-1,2,3,4-tetrol
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Other Signal Transduction Pathway Modulators
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-314-M001
1 mg
90.00 USD
ALX-350-314-M005
5 mg
360.00 USD
Product Specification
FORMULA:
C
7
H
13
NO
4
MW:
175.2
CAS NUMBER:
127414-85-1
SOURCE/HOST:
Isolated from
Lycopersicon sp.
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Selective glycosidase inhibitor sharing such activity with other hydroxylated nitrogen containing bicyclic compounds like swainsonine (Prod. No.
ALX-350-077
), castanospermine (Prod. No.
ALX-270-160
), monocyclic deoxynojirimycin (Prod. No.
ALX-580-003
) or fagomine. Most abundant form is calystegine B2 occurring in almost all plants displaying calystegines. Inhibitory potency of calystegine B2 is comparable to other alkaloidal glycosidase inhibitors showing K
i
values below 1µM.
Product Specific Literature References
Identification of the glycosidase inhibitors swainsonine and calystegine B2 in Weir vine (Ipomoea sp. Q6 [aff. calobra]) and correlation with toxicity:
R.J. Molyneux, et al.; J. Nat. Prod.
58
, 878 (1995)
Abstract
The effects of calystegines isolated from edible fruits and vegetables on mammalian liver glycosidases:
N. Asano, et al.; Glycobiology
70
, 1085 (1997)
Abstract
Synthesis and evaluation of calystegine B2 analogues as glycosidase inhibitors:
M.I. Garcia-Moreno, et al.; J. Org. Chem.
66
, 7604 (2001)
Abstract
Biosynthesis of calystegines: 15N NMR and kinetics of formation in root cultures of Calystegia sepium:
Y. Scholl, et al.; Phytochemistry
62
, 325 (2003)
Abstract
Chemistry and biology of calystegines:
B. Drager; Nat. Prod. Rep.
21
, 211 (2004)
Abstract
Calystegines in potatoes with genetically engineered carbohydrate metabolism:
U. Richter, et al.; J. Exp. Bot.
58
, 1603 (2007)
Abstract
Related Products
ALX-270-160
Castanospermine
ALX-350-077
Swainsonine
ALX-580-003
1-Deoxynojirimycin
Further Categories Containing This Product:
Glycosidases/Related Products
•
Alkaloids
•
Active Substances from Fruit and Vegetables
ALX-350-015
Revised 03-Apr-08
(S)-(+)-Camptothecin
