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ALX-350-158 Revised 13-May-08 New product
Aloesin
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SYNONYMS Aloeresin B
NSC 631262
8-β-D-Glucopyranosyl-7-hydroxy-5-methyl-2-(2-oxopropyl)-4H-1-benzopyran-4-one
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Anti-inflammatory Agents
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ALX-350-158-M001   1 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C19H22O9
MW: 394.4
CAS NUMBER: 30861-27-9
SOURCE/HOST: Isolated from Aloe sp.
PURITY: ≥98% (HPLC)
APPEARANCE: Pale yellow to brown powder.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR and MS.

Product Description
C-glycosylated chromone compound. Competitive inhibitor of tyrosinase. Shows weak free radical scavenging activity. Anti-inflammatory. Modulates melanogenesis (pigmentation-altering agent). Used in the cosmetic industry.
Product Specific Literature References
The distribution of aloesin in some South African Aloe species: T.J. McCarthy & L.J. Haynes; Planta Med. 15, 342 (1967) Abstract
Chromones in aloe species. I. Aloesin--a C-glucosyl-7-hydroxychromone: D.K. Holdsworth; Planta Med. 19, 322 (1971) Abstract
Aloesin up-regulates cyclin E/CDK2 kinase activity via inducing the protein levels of cyclin E, CDK2, and CDC25A in SK-HEP-1 cells: K.Y. Lee, et al.; Biochem. Mol. Biol. Int. 41, 285 (1997) Abstract
Modulation of melanogenesis by aloesin: a competitive inhibitor of tyrosinase: K. Jones, et al.; Pigment Cell Res. 15, 335 (2002) Abstract
Antioxidant, free radical scavenging and anti-inflammatory effects of aloesin derivatives in Aloe vera: A. Yagi, et al.; Planta Med. 68, 957 (2002) Abstract
Mushroom tyrosinase inhibition activity of some chromones: L.Z. Piao, et al.; Chem. Pharm. Bull. (Tokyo) 50, 309 (2002) Abstract
Aloesin inhibits hyperpigmentation induced by UV radiation: S. Choi, et al.; Clin. Exp. Dermatol. 27, 513 (2002) Abstract
Determination of aloesin and aloeresin A for the detection of aloe in beverages: M. Dell Agli, et al.; J. Agric. Food Chem. 55, 3363 (2007) Abstract
Aloeresin I, an anti-inflammatory 5-methylchromone from cape aloe: G. Speranza, et al.; Planta Med. 71, 79 (2005) Abstract
Related Products
 
 
ALX-350-139 Revised 18-Feb-08
Alternariol
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SYNONYMS AOH
3,7,9-Trihydroxy-1-methyl-6H-dibenzo(b,d)pyran-6-one
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Mycotoxins
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ALX-350-139-M001   1 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C14H10O5
MW: 258.2
CAS NUMBER: 641-38-3
RTECS: HP8757000
SOURCE/HOST: Isolated from Alternaria sp.
PURITY: ≥97% (HPLC)
APPEARANCE: Off-white to brown solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: VERY TOXIC. MAY BE MUTAGENIC.
IDENTITY: Identity determined by MS, 1H-NMR.

Product Description
Mycotoxin contaminant of fruit and cereal products. Exhibits antifungal and phytotoxic activity. Cholinesterase inhibitor.
Product Specific Literature References
Studies in the biochemistry of micro-organisms. 90. Alternariol and alternariol monomethyl ether, metabolic products of Alternaria tenuis: H. Raistrick, et al.; Biochem. J. 55, 421 (1953) Abstract; Full Text
Studies in the biosynthesis of fungal metabolites. 2. The biosynthesis of alternariol and its relation to other fungal phenols: R. Thomas; Biochem. J. 78, 748 (1961) Abstract; Full Text
Effect of substrate on metabolite production of Alternaria alternata: R. Burroughs, et al.; Appl. Environ. Microbiol. 31, 685 (1976) Abstract; Full Text
Light inhibits the production of alternariol and alternariol monomethyl ether in Alternaria alternata: K. Soderhall, et al.; Appl. Environ. Microbiol. 36, 655 (1978) Abstract; Full Text
Toxicity of the Alternaria metabolites alternariol, alternariol methyl ether, altenuene, and tenuazonic acid in the chicken embryo assay: G.F. Griffin and F.S. Chu; Appl. Environ. Microbiol. 46, 1420 (1983) Abstract; Full Text
Alternariol, a dibenzopyrone mycotoxin of Alternaria spp., is a new photosensitizing and DNA cross-linking agent: F. DiCosmo and N.A. Straus; Experientia 41, 1188 (1985) Abstract
Nitrogen inhibition of mycotoxin production by Alternaria alternata: M. Orvehed, et al.; Appl. Environ. Microbiol. 54, 2361 (1988) Abstract; Full Text
Evaluation of alternariol and alternariol methyl ether for mutagenic activity in Salmonella typhimurium: V.M. Davis and M.E. Stack; Appl. Environ. Microbiol. 60, 3901 (1994) Abstract; Full Text
The inhibitory effect of extracts from Fructus lycii and Rhizoma polygonati on in vitro DNA breakage by alternariol: D.S. Xu, et al.; Biomed. Environ. 9, 67 (1996) Abstract
Total synthesis of alternariol: K. Koch, et al.; J. Org. Chem. 70, 3275 (2005) Abstract
Mutagenicity of the mycotoxin alternariol in cultured mammalian cells: E.M. Brugger, et al.; Toxicol. Lett. 164, 221 (2006) Abstract
Estrogenic and clastogenic potential of the mycotoxin alternariol in cultured mammalian cells: L. Lehmann, et al.; Food Chem. Toxicol. 44, 398 (2006) Abstract
Further examination of the effects of nitrosylation on Alternaria alternata mycotoxin mutagenicity in vitro: T.J. Schrader, et al.; Mutat. Res. 606, 61 (2006) Abstract
Novel oxidative in vitro metabolites of the mycotoxins alternariol and alternariol methyl ether: E. Pfeiffer, et al.; Mol. Nutr. Food Res. 51, 307 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Antifungal Agents
 
 
ALX-350-162 Revised 11-Aug-08 New product
Altersolanol A
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SYNONYMS As-A 2
NSC 173943
(1R-(1α,2β,3β,4α))-1,2,3,4-Tetrahydro-1,2,3,4,5-pentahydroxy-7-methoxy-2-methyl-9,10-anthracenedione
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products with Antibiotic Activity
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ALX-350-162-M001   1 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C16H16O8
MW: 336.3
CAS NUMBER: 22268-16-2
SOURCE/HOST: Isolated from Alternaria sp.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow-orange to brown solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR and MS.

Product Description
Tetrahydroanthraquinone with phytotoxic and antibacterial activity.
Product Specific Literature References
Metabolites of Dactylaria lutea. The structures of dactylariol and the antiprotozoal antibiotic dactylarin: A.M. Becker, et al.; J. Antibiot. (Tokyo) 31, 324 (1978) Abstract
High-performance liquid chromatographic determination of macrosporin, altersolanol A, alterporriol A, B and C in fermentation of Alternaria porri (Ellis) Ciferri: R. Suemitsu, et al.; J. Chromatogr. 454, 406 (1988) Abstract
Mode of phytotoxic action of altersolanols : H. Haraguchi, et al.; Phytochemistry 43, 989 (1996)
Biologically active polyketide metabolites from an undetermined fungicolous hyphomycete resembling Cladosporium: U. Höller, et al.; J. Nat. Prod. 54, 876 (2002) Abstract
Secondary metabolite profiling of Alternaria dauci, A. porri, A. solani, and A. tomatophila: B. Andersen, et al.; Mycol. Res. 112, 241 (2008) Abstract
 
 
ALX-350-270 Revised 08-Feb-08
α-Amanitin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation / Transcription
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ALX-350-270-M001   1 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C39H54N10O14S
MW: 919.0
CAS NUMBER: 23109-05-9
MERCK INDEX: 14: 373
RTECS: BD6195000
SOURCE/HOST: Isolated from Amanita phalloides mushrooms.
PURITY: ≥90%
APPEARANCE: White to light yellow powder.
SOLUBILITY: Soluble in 100% ethanol (5mg/ml), DMSO, dimethyl formamide, methanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Dilute with buffer immediately prior to use. Product is destroyed by concentrated acid or base.
HANDLING: Protect from light.
HAZARD: VERY TOXIC.

Product Description
Inhibits eukaryotic RNA-polymerase II with high efficiency, but not eukaryotic RNA-polymerase I, or bacterial or viral RNA-polymerases. Inhibits mammalian protein synthesis.
Product Specific Literature References
Effect of alpha-amanitin on ribonucleic acid synthesis and on ribonucleic acid polymerase in mouse liver: F. Stirpe & L. Fiume; Biochem. J. 103, 67P (1967) Abstract
Specific inhibition of nuclear RNA polymerase II by alpha-amanitin: T.J. Lindell, et al.; Science 170, 447 (1970) Abstract
Fifty years of amanitin: T. Wieland & H. Faulstich; Experientia 47, 1189 (1991), (Review) Abstract
Alpha-amanitin blocks translocation by human RNA polymerase II: X.Q. Gong, et al.; J. Biol. Chem. 279, 27422 (2004) Abstract
Further Categories Containing This Product:
Amanitins & Phalloidins / Related Products • Protein Synthesis Other Products • RNA Polymerases / Related Products
 
 
ALX-350-271 Revised 08-Oct-07
β-Amanitin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation / Transcription
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ALX-350-271-M001   1 mg 170.00 USD Add To Cart
Product Specification
FORMULA: C39H53N9O15S
MW: 920.0
CAS NUMBER: 21150-22-1
MERCK INDEX: 14: 373
SOURCE/HOST: Isolated from Amanita phalloides mushrooms.
PURITY: ≥90%
FORMULATION: White to off-white powder.
SOLUBILITY: Soluble in DMSO, dimethyl formamide, methanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Dilute with buffer immediately prior to use. Product is destroyed by concentrated acid or base.
HANDLING: Protect from light.
HAZARD: VERY TOXIC.

Product Description
Biological activity like α-amanitin (Prod. No. ALX-350-270), but contains a carboxy group which is useful for coupling reactions.
Further Categories Containing This Product:
Amanitins & Phalloidins / Related Products • Protein Synthesis Other Products • RNA Polymerases / Related Products
 
 
ALX-350-272 Revised 17-Dec-07
γ-Amanitin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation / Transcription
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ALX-350-272-M001   1 mg 170.00 USD Add To Cart
Product Specification
FORMULA: C39H54N10O13S
MW: 903.0
CAS NUMBER: 13567-11-8; 21150-23-2
MERCK INDEX: 14: 373
SOURCE/HOST: Isolated from Amanita phalloides mushrooms.
PURITY: ≥90%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO, dimethyl formamide or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Dilute with buffer immediately prior to use. Product is destroyed by concentrated acid or base.
HANDLING: Protect from light.
HAZARD: VERY TOXIC.

Product Description
Biological activity like α-amanitin (Prod. No. ALX-350-270).
Further Categories Containing This Product:
Amanitins & Phalloidins / Related Products • Protein Synthesis Other Products • RNA Polymerases / Related Products
 
 
ALX-380-262 Revised 09-Apr-08
Amidepsine A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products
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ALX-380-262-M001   1 mg 230.00 USD Add To Cart
ALX-380-262-MM25   2.5 mg 470.00 USD Add To Cart
Product Specification
FORMULA: C29H29NO11
MW: 567.6
SOURCE/HOST: Isolated from fungal strain FO-2943.
PURITY: ≥95% (HPLC)
APPEARANCE: Pale white to pale yellow powder.
SOLUBILITY: Soluble in methanol or ethyl acetate; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Inhibitor of diacylglycerol acyltransferase (DGAT). Shows inhibitory effect in rat liver microsomes (IC50=10.2µM) and Raji cells (IC50=15.5µM). Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver, obesity and hypertriglyceridemia, which may lead to atherosclerosis, diabetes and metabolic disorders.
Product Specific Literature References
Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. I. Production, isolation and biological properties: H. Tomoda, et al.; J. Antibiot. 48, 937 (1995) Abstract
Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. II. Structure elucidation of amidepsines A, B and C: H. Tomoda, et al.; J. Antibiot. 48, 942 (1995) Abstract
General Information
MANUFACTURER Fungal strain courtesy of the Kitasato Institute, Tokyo.
Related Products
Further Categories Containing This Product:
Lipid Metabolism Other Products
 
 
ALX-380-263 Revised 09-Apr-08
Amidepsine D
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products
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ALX-380-263-M001   1 mg 230.00 USD Add To Cart
ALX-380-263-MM25   2.5 mg 470.00 USD Add To Cart
Product Specification
FORMULA: C26H24O10
MW: 496.5
SOURCE/HOST: Isolated from fungal strain FO-2943.
PURITY: ≥95% (HPLC)
APPEARANCE: White to light pink powder.
SOLUBILITY: Soluble in methanol (1mg/ml); insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Inhibitor of diacylglycerol acyltransferase (DGAT). Shows inhibitory effect in rat liver microsomes (IC50=17.5µM) and Raji cells (IC50=2.8µM). Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver, obesity and hypertriglyceridemia, which may lead to atherosclerosis, diabetes and metabolic disorders.
Product Specific Literature References
Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. I. Production, isolation and biological properties: H. Tomoda, et al.; J. Antibiot. 48, 937 (1995) Abstract
Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. II. Structure elucidation of amidepsines A, B and C: H. Tomoda, et al.; J. Antibiot. 48, 942 (1995) Abstract
General Information
MANUFACTURER Fungal strain courtesy of the Kitasato Institute, Tokyo.
Related Products
Further Categories Containing This Product:
Lipid Metabolism Other Products
 
 
ALX-385-021 Revised 23-Oct-07
4'-Amino-6-hydroxyflavone
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SYNONYMS Aminogenistein
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonoids / Related Products
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ALX-385-021-M001   1 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C15H11NO3
MW: 253.3
PURITY: ≥95%
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Inhibitor of the p56lck protein-tyrosine kinase.
Product Specific Literature References
Synthesis and protein-tyrosine kinase inhibitory activities of flavonoid analogues: M. Cushman, et al.; J. Med. Chem. 34, 798 (1991) Abstract
Expression of p56lck in B-cell neoplasias: A. Von Knethen, et al.; Leuk. Lymphoma 26, 551 (1997) Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors • Src Family Kinases / Related Products • Kinases in T Cell Signal Transduction / Related Products
 
 
ALX-350-112 Revised 29-Nov-07
Anabasine . hydrochloride
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