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Nitric Oxide Pathway Other Products
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ALX-101-018 Revised 30-Jan-06
L-Glutamic acid
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PRODUCT LINE Combinatorial Chemistry
PRODUCT CATEGORY L-Amino Acids
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ALX-101-018-G001   1 g 12.00 USD Add To Cart
Product Specification
FORMULA: C5H9NO4
MW: 147.1
CAS NUMBER: 56-86-0
MERCK INDEX: 14: 4469
RTECS: LZ9700000
PURITY: ≥99%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Further Categories Containing This Product:
Excitatory Amino Acids • Nitric Oxide Pathway Other Products
 
 
ALX-200-089 Revised 18-Mar-08
Ceruloplasmin (human)
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SYNONYMS Ferroxidase (human)
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Nitric Oxide Pathway Other Products
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ALX-200-089-M001   1 mg 210.00 USD Add To Cart
Product Specification
MW: ~134kDa
CAS NUMBER: 9031-37-2
EC: 1.16.3.1
MERCK INDEX: 14: 2006
SOURCE/HOST: Isolated from human plasma.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Plasma has been tested negative for HBsAg and for antibodies to HIV and HCV.
FORMULATION: Lyophilized from 50mM potassium phosphate, pH 6.8, containing 100mM potassium chloride, 20mM ε-aminocaproic acid and 5mM EDTA.
RECONSTITUTION: Reconstitute with water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Description
Serum copper transport and iron-oxidizing protein. Expressed in plasma at concentrations of 1-5µM. Contains six copper centers and is known to oxidize amines in a process coupled to the reduction of molecular oxygen. Has ferroxidase activity that is responsible for the oxidation of ferrous iron to its ferric form, which is necessary for efficient iron efflux from the cell (e.g. during hypoxia). Has previously been considered a target for nitric oxide (NO) and an inhibitor of endothelial nitric oxide synthase (eNOS/NOS III). Catalyzes S-nitrosothiol formation in cell culture media. Is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis.
Product Specific Literature References
The reaction of nitric oxide with ceruloplasmin: R. Wever, et al.; Biochim. Biophys. Acta 302, 236 (1973) Abstract
Copper transport: an overview: E.D. Harris; Proc. Soc. Exp. Biol. Med. 196, 130 (1991) Abstract
Ceruloplasmin inhibits carbonyl formation in endogenous cell proteins: J.A. Krsek-Staples & R.O. Webster; Free Radic. Biol. Med. 14, 115 (1993) Abstract
Antioxidant protection against organic and inorganic oxygen radicals by normal human plasma: the important primary role for iron-binding and iron-oxidising proteins: J.M. Gutteridge & G.J. Quinlan; Biochim. Biophys. Acta 1156, 144 (1993) Abstract
Inhibition of endothelial nitric-oxide synthase by ceruloplasmin: A. Bianchini, et al.; J. Biol. Chem. 274, 20265 (1999) Abstract; Full Text
The reactions of copper proteins with nitric oxide: J. Torres and M.T. Wilson; Biochim. Biophys. Acta 1411, 310 (1999) Abstract
Role of ceruloplasmin in macrophage iron efflux during hypoxia: J. Sarkar, et al.; J. Biol. Chem. 278, 44018 (2003) Abstract; Full Text
Does oxidative stress change ceruloplasmin from a protective to a vasculopathic factor?: N. Shukla, et al.; Atherosclerosis 187, 238 (2006) Abstract
Ceruloplasmin is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis: S. Shiva, et al.; Nat. Chem. Biol. 2, 486 (2006) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P00450: Ceruloplasmin (human) [Precursor]
Further Categories Containing This Product:
Serum Proteins Other Products • Natural Proteins
 
 
ALX-202-034 Revised 13-Dec-04
Calcineurin (bovine brain)
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SYNONYMS Calmodulin Binding Protein (bovine brain)
Protein Phosphatase 2B (bovine brain)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PP2B [Calcineurin] / Related Products
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ALX-202-034-U100   100 U 590.00 USD Add To Cart
Product Specification
CAS NUMBER: 9025-75-6
EC: 3.1.3.16
MERCK INDEX: 14: 1640
SOURCE/HOST: Isolated from bovine brain.
FORMULATION: Lyophilized powder containing ~1% protein (Lowry) and 0.5% EGTA, buffer salts and stabilizers.
SPECIFIC ACTIVITY: ~2'500-5'000U/mg protein. One unit causes a 50% inhibition of the activated phosphodiesterase activity when assayed with 2 units of activator and 0.1mM Ca2+ in an enzyme coupled system at 30°C, pH 7.5.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Enzymes • Natural Proteins • Nitric Oxide Pathway Other Products
 
 
ALX-206-003 Revised 03-Mar-05
Nitrate Reductase (cytochrome)
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SYNONYMS Ferrocytochrome: Nitrate oxidoreductase
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Nitric Oxide Pathway Other Products
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ALX-206-003-UC05   0.5 U 220.00 USD Add To Cart
Product Specification
CAS NUMBER: 9029-42-9
EC: 1.9.6.1
SOURCE/HOST: Produced in E. coli.
APPEARANCE: Light tan powder.
FORMULATION: Lyophilized.
SOLUBILITY: Soluble in water (2.5mg/ml).
SPECIFIC ACTIVITY: ≥5U/g solid. One unit is defined as the amount of enzyme that reduces 1.0µM of nitrate to nitrite per min. at pH 7.0 at 30°C in a methylviologen system.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Enzymes
 
 
ALX-270-112 Revised 16-Jun-08
Pentoxifylline
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SYNONYMS Trental
3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
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ALX-270-112-G001   1 g 15.00 USD Add To Cart
ALX-270-112-G005   5 g 35.00 USD Add To Cart
Product Specification
FORMULA: C13H18N4O3
MW: 278.3
CAS NUMBER: 6493-05-6
MERCK INDEX: 14: 7136
SOURCE/HOST: Isolated from Penicillium expansum.
PURITY: ≥99%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Phosphodiesterase inhibitor. Blocks the synthesis of TNF-α. Improves blood flow by decreasing blood viscosity.
Product Specific Literature References
Pentoxifylline inhibits lipopolysaccharide-induced serum tumor necrosis factor and mortality: P. Noel, et al.; Life Sci. 47, 1023 (1990) Abstract
Pentoxifylline inhibits the expression of tissue factor mRNA in endotoxin-activated human monocytes: V. Ollivier, et al.; FEBS Lett. 322, 231 (1993) Abstract
Pentoxifylline: C.P. Samlaska & E.A. Winfield; J. Am. Acad. Dermatol. 30, 603 (1994), Review Abstract
Suppression of hypercholesterolemic atherosclerosis by pentoxifylline and its mechanism: K. Prasad & P. Lee; Atherosclerosis 192, 313 (2007) Abstract
Further Categories Containing This Product:
Phosphodiesterases / Related Products • TNF-alpha & TNF Receptors Other Products • Nitric Oxide Pathway Other Products
 
 
ALX-340-004 Revised 18-Aug-08
Arachidonic acid
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SYNONYMS 5Z,8Z,11Z,14Z-Eicosatetraenoic acid
PRODUCT LINE Inflammation
PRODUCT CATEGORY Arachidonic Acid / Related Products
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ALX-340-004-M100   100 mg 147.00 USD Add To Cart
Product Specification
FORMULA: C20H32O2
MW: 304.5
CAS NUMBER: 506-32-1
MERCK INDEX: 14: 765
RTECS: CE6675000
CONCENTRATION: 100mg/ml
PURITY: ≥98%
FORMULATION: Liquid. Solution in ethanol containing 0.1% BHT.
SOLUBILITY: 100mg/ml soluble in DMSO or dimethyl formamide; sparingly soluble in basic aqueous buffers (1.7mg/ml). To prevent oxidation, the solvent should be purged with an inert gas.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C. Keep aqueous solutions on ice and use within 12 hours.
HANDLING: Protect from light and oxygen.
HAZARD: TOXIC.

Product Description
Precursor to a large family of eicosanoids. Activator for several protein kinase C (PKC) isotypes.
Product Specific Literature References
Arachidonic acid metabolism: P. Needleman, et al.; Ann. Rev. Biochem. 55, 69 (1986) Abstract
Kinetic analysis of the Ca2+-dependent, membrane-bound, macrophage phospholipase A2 and the effects of arachidonic acid: M.D. Lister, et al.; J. Biol. Chem. 263, 7506 (1988) Abstract; Full Text
Characterization of the L-arginine:nitric oxide pathway in human platelets: M.W. Radomski, et al.; Br. J. Pharmacol. 101, 325 (1990) Abstract
The LDL receptor pathway delivers arachidonic acid for eicosanoid formation in cells stimulated by platelet-derived growth factor: A.J.R. Habenicht, et al.; Nature 345, 634 (1990) Abstract
The control of free arachidonic acid levels: R.D. Burgoyne & A. Morgan; TIBS 15, 365 (1990) Abstract
A unique pool of free arachidonate serves as substrate for both cyclooxygenase and lipoxygenase in platelets: F. Chevy, et al.; Lipids 26, 1080 (1991) Abstract
Regulation of Ras-GAP and the neurofibromatosis-1 gene product by eicosanoids: J.W. Han, et al.; Science 252, 576 (1991) Abstract
Arachidonic acid as a second messenger. Interactions with a GTP-binding protein of human neutrophils: S.B. Abramson, et al.; J. Immunol. 147, 231 (1991) Abstract
The immediate activator of the NADPH oxidase is arachidonate not phosphorylation: Henderson, et al.; Eur. J. Biochem. 211, 157 (1993) Abstract
Nitric oxide and arachidonic acid modulation of calcium currents in postganglionic neurones of avian cultured ciliary ganglia: G. Khurana & M.R. Bennett; Br. J. Pharmacol. 109, 480 (1993) Abstract
Arachidonic acid-induced Ca2+ release from isolated sarcoplasmic reticulum: C. Dettbarn & P. Palade; Biochem. Pharmacol. 45, 1301 (1993) Abstract
Covalent binding of arachidonate to G protein alpha subunits of human platelets: H. Hallak, et al.; J. Biol. Chem. 269, 4713 (1994) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
PKC Activators • Nitric Oxide Pathway Other Products • Fatty Acids
 
 
ALX-370-007 Revised 19-Jun-06
Corticosterone
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SYNONYMS (11β)-11,21-Dihydroxypregn-4-ene-3,20-dione
Reichstein's Substance H
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Glucocorticoids & Glucocorticoid Receptors / Related Products
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ALX-370-007-M050   50 mg 18.00 USD Add To Cart
Product Specification
FORMULA: C21H30O4
MW: 346.5
CAS NUMBER: 50-22-6
MERCK INDEX: 14: 2538
RTECS: GM7650000
PURITY: ≥95%
APPEARANCE: Light yellow solid.
SOLUBILITY: Soluble in 100% ethanol (50mg/ml) or dioxane (20mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: MAY BE TERATOGENIC. IRRITANT.

Further Categories Containing This Product:
Apoptosis Inducers & Inhibitors Other Products • Nitric Oxide Pathway Other Products
 
 
ALX-400-023 Revised 19-Apr-06
Gadolinium (III) chloride . hexahydrate
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PRODUCT LINE Immunology
PRODUCT CATEGORY Monocytes & Macrophages Other Products
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ALX-400-023-M100   100 mg 15.00 USD Add To Cart
ALX-400-023-M500   500 mg 25.00 USD Add To Cart
Product Specification
FORMULA: GdCl3 . 6H2O
MW: 263.6 . 108.1
CAS NUMBER: 13450-84-5
MERCK INDEX: 14: 4326
PURITY: ≥99%
APPEARANCE: White crystals or chunks.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Packaged under inert gas. Hygroscopic.
HAZARD: IRRITANT.
Product Description
Inhibits macrophages.
Product Specific Literature References
Inhibition of macrophages with gadolinium chloride abrogates ozone- induced pulmonary injury and inflammatory mediator production: K.J. Pendino, et al.; Am. J. Respir. Cell Mol. Biol. 13, 125 (1995) Abstract
Further Categories Containing This Product:
Nitric Oxide Pathway Other Products
 
 
ALX-430-020 Revised 05-Feb-07
Zaprinast
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SYNONYMS 1,4-Dihydro-5-[2-propoxyphenyl]-7H-1,2,3-triazolo[4,5-d]pyrimidine-7-one
M&B 22,948
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phosphodiesterases / Related Products
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ALX-430-020-M010   10 mg 30.00 USD Add To Cart
ALX-430-020-M050   50 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C13H13N5O2
MW: 271.3
CAS NUMBER: 37762-06-4
PURITY: ≥98%
APPEARANCE: White to light yellow powder.
SOLUBILITY: Soluble in 1M sodium hydroxide.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: IRRITANT.

Product Description
Phosphodiesterase (PDE) inhibitor.
Product Specific Literature References
Inhibition and stimulation of photoreceptor phosphodiesterases by dipyridamole and M&B 22,948: P.G. Gillespie and J.A. Beavo; Mol. Pharmacol. 36, 773 (1989) Abstract
Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors: J.A. Beavo & D.H. Reifsnyder; TIPS 11, 150 (1990) Abstract
The catalytic subunit of protein kinase A triggers activation of the type V cyclic GMP-specific phosphodiesterase from guinea-pig lung: F. Burns, et al.; Biochem. J. 283, 487 (1992) Abstract
Cyclic nucleotide phosphodiesterases from frog atrial fibers: isolation and drug sensitivities: C. Lugnier, et al.; Am. J. Physiol. 262, H654 (1992) Abstract
Zaprinast increases cyclic GMP levels in plasma and in aortic tissue of rats: R.L. Dundore, et al.; Eur. J. Pharmacol. 249, 293 (1993) Abstract
Reversal of nitroglycerin tolerance in vitro by the cGMP- phosphodiesterase inhibitor zaprinast: E.D. Pagani, et al.; Eur. J. Pharmacol. 243, 141 (1993) Abstract
The nitric oxide--cyclic GMP pathway and synaptic depression in rat hippocampal slices: C.L. Boulton, et al.; Eur. J. Neurosci. 6, 1528 (1994) Abstract
The PDE inhibitor zaprinast enhances NO-mediated protection against vascular leakage in reperfused lungs: H. Schutte, et al.; Am. J. Physiol. Lung Cell Mol. Physiol. 279, L496 (2000) Abstract; Full Text
Phosphodiesterase 5 inhibitor, zaprinast, selectively increases cerebral blood flow in the ischemic penumbra in the rat brain: F. Gao, et al.; Neurol. Res. 27, 638 (2005) Abstract
Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35: Y. Taniguchi, et al.; FEBS Lett. 580, 5003 (2006) Abstract
Further Categories Containing This Product:
Nitric Oxide Pathway Other Products
 
 
ALX-430-021 Revised 17-Jan-05
N-Acetyl-N-acetoxy-4-chlorobenzenesulphonamide
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PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Nitric Oxide Pathway Other Products
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ALX-430-021-M005   5 mg 40.00 USD Add To Cart
Product Specification
FORMULA: C10H10ClNO5S
MW: 291.7
PURITY: ≥98%
APPEARANCE: White crystals.
SOLUBILITY: Soluble in DMSO or DMF; slightly soluble in methanol; not soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Nitroxyl (HNO) releasing compound in neutral solution. Release of nitric oxide was not detected. Potent vasorelaxant. Powerful inhibitor of aldehyde dehydrogenase.
Product Specific Literature References
Prodrugs of nitroxyl as inhibitors of aldehyde dehydrogenase: M.J.C. Lee, et al.; J. Med. Chem. 35, 3648 (1992) Abstract
N,O-diacylated-N-hydroxyarylsulfonamides: nitroxyl precursors with potent smooth muscle relaxant properties: J.M. Fukuto, et al.; BBRC 187, 1367 (1992) Abstract
 
 
ALX-440-008 Revised 30-Oct-06
L-Biopterin
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SYNONYMS 6-Biopterin
2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-4(1H)-pteridinone
2-Amino-4-hydroxy-6-(1,2-dihydroxypropyl)pteridine
L-erythro-6-(1,2-Dihydroxypropyl)pterin
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Nitric Oxide Pathway Other Products