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Tyrosine Kinase Inhibitors
You are here: Product Lines > Signal Transduction > Kinases / Related Products > Tyrosine Kinases / Related Products > Tyrosine Kinase Inhibitors
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ALX-270-168 Revised 18-May-06
Tyrphostin AG 490
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SYNONYMS Tyrphostin B42
N-Benzyl-3,4-dihydroxy-benzylidenecyanoacetamide
α-Cyano-(3,4-dihydroxy)-]N-benzylcinnamamide
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrphostins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-168-M005   5 mg 45.00 USD Add To Cart
ALX-270-168-M025   25 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C17H14N2O3
MW: 294.3
CAS NUMBER: 133550-30-8
PURITY: ≥98%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO and acetone; slightly soluble in 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Selectively inhibits CDK2 activation leading to a potent cell cycle arrest at late G1 and S phase. Cell permeable inhibitor of JAK-2 tyrosine kinase. Does not significantly inhibit other kinases, such as Lck, Lyn, Btk, Syk or Src. Blocks IL-7 induced JAK kinase activity in T cells (JAK-1, JAK-3) and the consequent phosphorylation of PI-3 kinase. Valuable tool for studying the cellular role of JAK kinases in signal transduction.
Product Specific Literature References
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors: A. Gazit, et al.; J. Med. Chem. 32, 2344 (1989) Abstract
Tyrosine phosphorylation is an obligatory event in IL-2 secretion [published erratum appears in J Immunol 1991 May 1;146(9):3260]: A. Levitzki; Biochem. Pharmacol. 40, 913 (1990) Abstract
Activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor is dependent on protein tyrosine kinase activity: H. Dadi, et al.; Blood 84, 1579 (1994) Abstract; Full Text
JAK3 protein tyrosine kinase mediates interleukin-7-induced activation of phosphatidylinositol-3’ kinase: N. Sharfe, et al.; Blood 86, 2077 (1995) Abstract; Full Text
Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor: N. Meydan, et al.; Nature 379, 645 (1996) Abstract
Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells: R.A. Kirken, et al.; J. Leukoc. Biol. 65, 891 (1999) Abstract
JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response: L.H. Wang, et al.; J. Immunol. 162, 3897 (1999) Abstract
JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cells: J. De Vos, et al.; Br. J. Haematol. 109, 823 (2000) Abstract
Further Categories Containing This Product:
Janus Kinases [JAKs] / Related Products • Cell Cycle Blockers & Inhibitors / Related Products • Tyrosine Kinase Inhibitors • CDK & Cyclin Inhibitors
 
 
ALX-270-143 Revised 20-Feb-08
Tyrphostin AG 494
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SYNONYMS Tyrphostin B48
N-Phenyl-3,4-dihydroxybenzylidenecyanoacetamide
α-Cyano-(3,4-dihydroxy)-N-phenylcinnamamide
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrphostins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-143-M005   5 mg 25.00 USD Add To Cart
ALX-270-143-M025   25 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C16H12N2O3
MW: 280.3
CAS NUMBER: 133550-35-3
PURITY: ≥98%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Blocks CDK2 activation and causes cells to arrest at late G1 and during S phase.
Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases: A. Gazit, et al.; J. Med. Chem. 34, 1896 (1991) Abstract
Tyrphostin AG 494 blocks Cdk2 activation: N. Osherov & A. Levitzki; FEBS Lett. 410, 187 (1997) Abstract
Inhibition of Cdk2 activation by selected tyrphostins causes cell cycle arrest at late G1 and S phase: N. Kleinberger-Doron, et al.; Exp. Cell Res. 241, 340 (1998) Abstract
Further Categories Containing This Product:
EGFR Kinase Inhibitors • Tyrosine Kinase Inhibitors • Cell Cycle Blockers & Inhibitors / Related Products • CDK & Cyclin Inhibitors
 
 
ALX-270-141 Revised 07-Dec-04
Tyrphostin AG 527
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SYNONYMS Tyrphostin B44
(-)-(R)-N-(α-Methylbenzyl)-3,4-dihydroxybenzylidenecyanoacetamide
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrphostins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-141-M005   5 mg 25.00 USD Add To Cart
ALX-270-141-M025   25 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C18H16N2O3
MW: 308.3
CAS NUMBER: 133550-32-0
PURITY: ≥98%
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Store tightly sealed in the dark. Protect from light.

Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases: A. Gazit, et al.; J. Med. Chem. 34, 1896 (1991) Abstract
Further Categories Containing This Product:
EGFR Kinase Inhibitors • Tyrosine Kinase Inhibitors
 
 
ALX-270-142 Revised 11-Dec-04
Tyrphostin AG 555
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SYNONYMS Tyrphostin B46
N-(3-Phenylpropyl)-3,4-dihydroxy-benzylidenecyanoacetamide
α-Cyano-(3,4-dihydroxy)-N-(3-phenylpropyl)cinnamamide
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrphostins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-142-M005   5 mg 25.00 USD Add To Cart
ALX-270-142-M025   25 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C19H18N2O3
MW: 322.4
PURITY: ≥98%
SOLUBILITY: Soluble in DMSO or ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Store tightly sealed in the dark. Protect from light.

Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases: A. Gazit, et al.; J. Med. Chem. 34, 1896 (1991) Abstract
Further Categories Containing This Product:
EGFR Kinase Inhibitors • Tyrosine Kinase Inhibitors
 
 
ALX-270-146 Revised 11-Dec-04
Tyrphostin AG 556
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SYNONYMS Tyrphostin B56
N-(4-Phenylbutyl)-3,4-dihydroxybenzylidenecyanoacetamide
α-Cyano-(3,4-dihydroxy)-N-(4-phenylbutyl)cinnamamide
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrphostins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-146-M005   5 mg 25.00 USD Add To Cart
ALX-270-146-M025   25 mg 85.00 USD Add To Cart
Product Specification
FORMULA: C20H20N2O3
MW: 336.4
CAS NUMBER: 133550-41-1
PURITY: ≥98%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Store tightly sealed in the dark. Protect from light.

Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases: A. Gazit, et al.; J. Med. Chem. 34, 1896 (1991) Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors • EGFR Kinase Inhibitors
 
 
ALX-270-144 Revised 07-Dec-04
Tyrphostin AG 835
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SYNONYMS Tyrphostin B50
(+)-(S)-N-(α-Methylbenzyl)-3,4-dihydroxybenzylidenecyanoacetamide
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrphostins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-144-M005   5 mg 25.00 USD Add To Cart
ALX-270-144-M025   25 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C18H16N2O3
MW: 308.3
CAS NUMBER: 133550-37-5
PURITY: ≥98%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Store tightly sealed in the dark. Protect from light.

Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases: A. Gazit, et al.; J. Med. Chem. 34, 1896 (1991) Abstract
Further Categories Containing This Product:
EGFR Kinase Inhibitors • Tyrosine Kinase Inhibitors
 
 
ALX-270-035 Revised 07-Dec-04
Tyrphostin AG 1295
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SYNONYMS 6,7-Dimethyl-2-phenylquinoxaline
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrphostins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-035-M001   1 mg 30.00 USD Add To Cart
ALX-270-035-M005   5 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C16H14N2
MW: 234.3
CAS NUMBER: 71897-07-9
PURITY: ≥98%
APPEARANCE: Tan solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Store tightly sealed in the dark. Protect from light.

Further Categories Containing This Product:
EGFR Kinase Inhibitors • Tyrosine Kinase Inhibitors
 
 
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