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ALX-350-353 Revised 16-Jun-08
Chlorogenic acid
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SYNONYMS 1,3,4,5-Tetrahydroxycyclohexanecarboxylic acid 3-(3,4-dihydroxycinnamate)
3-O-Caffeoylquinic acid
Heriguard
NSC 407296
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Chemopreventive Agents
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-353-M500   500 mg 35.00 USD Add To Cart
ALX-350-353-G001   1 g 65.00 USD Add To Cart
Product Specification
FORMULA: C16H18O9
MW: 354.3
CAS NUMBER: 327-97-9
MERCK INDEX: 14: 2142
RTECS: GU8480000
SOURCE/HOST: Isolated from the leaves and fruits of dicotyledonous plants (e.g. coffee beans).
PURITY: ≥95%
APPEARANCE: White to off-white solid.
SOLUBILITY: 25mg/ml soluble in 100% ethanol, DMSO, dimethyl formamide or PBS (pH 7.2).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: We do not recommend storing the aqueous solution for more than one day.

Product Description
Analog of caffeic acid (Prod. No. ALX-270-231). Shows antioxidant, analgesic, antipyretic and chemopreventive activity. Inhibits Bcr-Abl tyrosine kinase and triggers MAP kinases p38-dependent apoptosis. Inhibitor of the tumor promoting activity of phorbol esters.
Product Specific Literature References
[Chlorogenic acid in coffee beans and their change during the roasting process. Report 1. Qualitative studies]: R. Krasemann; Arch. Pharm. 293, 721 (1960) Abstract
Studies on the activities of tannins and related compounds, X. Effects of caffeetannins and related compounds on arachidonate metabolism in human polymorphonuclear leukocytes: Y. Kimura, et al.; J. Nat. Prod. 50, 392 (1987) Abstract
Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate: M.T. Huang, et al.; Cancer Res. 48, 5941 (1988) Abstract; Full Text
Inhibitory effect of curcumin and some related dietary compounds on tumor promotion and arachidonic acid metabolism in mouse skin: A.H. Conney, et al.; Adv. Enzyme Regul. 31, 385 (1991) Abstract
Chlorogenic acid inhibits Bcr-Abl tyrosine kinase and triggers p38 mitogen-activated protein kinase-dependent apoptosis in chronic myelogenous leukemic cells: G. Bandyopadhyay, et al.; Blood 104, 2514 (2004) Abstract; Full Text
Inhibition of activator protein-1, NF-kappaB, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid: R. Feng, et al.; J. Biol. Chem. 280, 27888 (2005) Abstract; Full Text
The chemopreventive properties of chlorogenic acid reveal a potential new role for the microsomal glucose-6-phosphate translocase in brain tumor progression: A. Belkaid, et al.; Cancer Cell Int. 6, 7 (2006) Abstract; Full Text
Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid: M.D. dos Santos, et al.; Biol. Pharm. Bull. 29, 2236 (2006) Abstract; Full Text
Inhibition of DNA methylation by caffeic acid and chlorogenic acid, two common catechol-containing coffee polyphenols: W.J. Lee & B.T. Zhu; Carcinogenesis 27, 269 (2006) Abstract; Full Text
Related Products
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables • MAPK Pathway Activators • Natural Products - Antioxidants • Natural Products for Neurological Research • Natural Products - Apoptosis Inducers & Inhibitors • Analgesic / Anti-nociceptive Agents / Related Products
 
 
ALX-385-009 Revised 03-Apr-08
Chrysin
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SYNONYMS 5,7-Dihydroxyflavone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonoids / Related Products
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ALX-385-009-G001   1 g 15.00 USD Add To Cart
Product Specification
FORMULA: C15H10O4
MW: 254.2
CAS NUMBER: 480-40-0
MERCK INDEX: 14: 2256
RTECS: LK8329050
PURITY: ≥96%
APPEARANCE: Yellow to tan solid.
SOLUBILITY: Soluble in pyridine or alkaline solutions; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Antioxidant flavonoid. Shows anti-inflammatory and antitumor properties. Inhibits hypoxia-inducible factor-1α (HIF-1α). Induces apoptosis.
Product Specific Literature References
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Chrysin-induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells: K.J. Woo, et al.; Biochem. Biophys. Res. Commun. 325, 1215 (2004) Abstract
Chrysin induces G1 phase cell cycle arrest in C6 glioma cells through inducing p21Waf1/Cip1 expression: involvement of p38 mitogen-activated protein kinase: M.S. Weng, et al.; Biochem. Pharmacol. 69, 1815 (2005) Abstract
Dietary flavonoids: effects on xenobiotic and carcinogen metabolism:: Y.J. Moon, et al.; Toxicol. In Vitro 20, 187 (2006), (Review) Abstract
Chrysin inhibits expression of hypoxia-inducible factor-1alpha through reducing hypoxia-inducible factor-1alpha stability and inhibiting its protein synthesis: B. Fu, et al.; Mol. Cancer Ther. 6, 220 (2007) Abstract
Further Categories Containing This Product:
Hypoxia-inducible Factor [HIF] / Related Products • Natural Products - Antitumor Reagents • Natural Products - Anti-inflammatory Agents • Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-350-365 Revised 11-Feb-08
Cinnamtannin B-1
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SYNONYMS Epicatechin-(4β→8,2β→O→7)-epicatechin-(4α→8)-epicatechin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Apoptosis Inducers & Inhibitors
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ALX-350-365-M005   5 mg 230.00 USD Add To Cart
Product Specification
FORMULA: C45H36O18
MW: 864.7
CAS NUMBER: 88082-60-4
SOURCE/HOST: Isolated from Laurus nobilis L.
PURITY: ≥90% (1H-NMR)
APPEARANCE: Brown solid.
SOLUBILITY: Soluble in 100% ethanol, methanol or in a mixture of DMSO and water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Keep under inert gas.

Product Description
A-type proanthocyanidin contained in several plant species such as Laurus nobilis L., Vaccinium vitis-idaea, Parameria laevigata, Cinnamomum zeylanicum and Lindera umbellata. Has potent antioxidant activity. Protective agent against oxidative stress and apoptosis in human platelets. Reduces hyperaggregability in platelets from type 2 diabetic patients.
Product Specific Literature References
Pharmacological Studies on Linderae umbellatae Ramus, IV*. Effects of condensed tannin related compounds on peptic activity and stress-induced gastric lesions in mice: N. Ezaki, et al.; Planta Med. 51, 34 (1985) Abstract
Antitumor agents, 129. Tannins and related compounds as selective cytotoxic agents: Y. Kashiwada, et al.; J. Nat. Prod. 55, 1033 (1992) Abstract
Antioxidant activity of tannin components from Vaccinium vitis-idaea L: K.Y. Ho, et al.; J. Pharm. Pharmacol. 51, 1075 (1999) Abstract
Studies on the constituents of bark of Parameria laevigata Moldenke: K. Kamiya, et al.; Chem. Pharm. Bull. 49, 551 (2001) Abstract; Full Text
Cinnamtannin B1 activity on adipocytes formation: M. Taher, et al.; Med. J. Malaysia 59, 97 (2004) Abstract
Phenolic constituents in the fruits of Cinnamomum zeylanicum and their antioxidant activity: G.K. Jayaprakasha, et al.; J. Agric. Food Chem. 54, 1672 (2006) Abstract
Characterization of the intracellular mechanisms involved in the antiaggregant properties of cinnamtannin B-1 from bay wood in human platelets: N. Ben Amor, et al.; J. Med. Chem. 50, 3937 (2007) Abstract
Cinnamtannin B-1 from bay wood exhibits antiapoptotic effects in human platelets: A. Bouaziz, et al.; Apoptosis 12, 489 (2007) Abstract
Cinnamtannin B-1 from bay wood reduces abnormal intracellular Ca2+ homeostasis and platelet hyperaggregability in type 2 diabetes mellitus patients: A. Bouaziz, et al.; Arch. Biochem. Biophys. 457, 235 (2007) Abstract
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables • Flavonoids / Related Products • Natural Products - Antioxidants
 
 
ALX-350-283 Revised 11-Jun-07
Cinobufagin
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SYNONYMS 5β,20(22)-Bufadienolide-3β,16β-diol-14,15β-epoxy 16-acetate
14,15β-Epoxy-3β,16β-dihydroxy-5β,20(22)-bufadienolide 16-acetate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - ATPase Inhibitors
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ALX-350-283-M005   5 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C26H34O6
MW: 442.6
CAS NUMBER: 470-37-1
PURITY: ≥99%
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.

Product Description
Specific Na+/K+-ATPase inhibitor. About as active as ouabain (Prod. No. ALX-350-066).
Product Specific Literature References
Metabolism and pharmacokinetics of cinobufagin: S. Toma, et al.; Xenobiotica 17, 1195 (1987) Abstract
Specific 12 beta-hydroxylation of cinobufagin by filamentous fungi: M. Ye, et al.; Appl. Environ. Microbiol. 70, 3521 (2004) Abstract
Cardiotonic steroids differentially affect intracellular Na+ and [Na+]i/[K+]i-independent signaling in C7-MDCK cells: O.A. Akimova, et al.; J. Biol. Chem. 280, 832 (2005) Abstract
Further Categories Containing This Product:
Natural Products - Apoptosis Inducers & Inhibitors • Na+ / K+-ATPase / Related Products • Natural Products - Immunomodulators • Antitumor Agents (Anti-proliferative)
 
 
ALX-350-284 Revised 11-Jun-07
Cinobufotalin
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SYNONYMS 14,15β-Epoxy-3β,5α,16β-trihydroxy-5β,20(22)-bufadienolide 16-acetate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - ATPase Inhibitors
Ordering Information
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ALX-350-284-M005   5 mg 85.00 USD Add To Cart
Product Specification
FORMULA: C26H34O7
MW: 458.6
CAS NUMBER: 1108-68-5
MERCK INDEX: 14: 2307
PURITY: ≥99%
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.

Product Description
Specific Na+/K+-ATPase inhibitor. Less active than ouabain (Prod. No. ALX-350-066).
Product Specific Literature References
Actions of bufalin and cinobufotalin, two bufadienolides respectively more active and less active than ouabain, on ouabain binding and 86Rb uptake by human erythrocytes: A.A. Brownlee, et al.; Clin. Sci. (Lond.) 78, 169 (1990) Abstract
Neutralization of cardiac toxins oleandrin, oleandrigenin, bufalin, and cinobufotalin by digibind: monitoring the effect by measuring free digitoxin concentrations: A. Dasgupta & L. Emerson ; Life Sci. 63, 781 (1998) Abstract
Simultaneous determination of four bufadienolides in human liver by high-performance liquid chromatography: Z. Wang, et al.; Biomed. Chromatogr. 18, 318 (2004) Abstract
Cardiotonic steroids differentially affect intracellular Na+ and [Na+]i/[K+]i-independent signaling in C7-MDCK cells: O.A. Akimova, et al.; J. Biol. Chem. 280, 832 (2005) Abstract
Further Categories Containing This Product:
Na+ / K+-ATPase / Related Products • Natural Products - Immunomodulators
 
 
ALX-350-335 Revised 14-Nov-07
Cochlioquinone A
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SYNONYMS Luteoleersin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Angiogenesis Research
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ALX-350-335-MC05   0.5 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C30H44O8
MW: 532.7
CAS NUMBER: 32450-25-2
SOURCE/HOST: Isolated from Bipolaris leersia MST-FP107.
PURITY: ≥99% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Shows antiangiogenic and nematocidal activities. Antagonist of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1). Inhibitor of diacylglycerol acyltransferase, diacylglycerol kinase and NADH-ubiquinone reductase.
Product Specific Literature References
Cochlioquinone A, a nematocidal agent which competes for specific [3H]ivermectin binding sites: J.M. Schaeffer, et al.; J. Antibiot. (Tokyo) 43, 1179 (1990) Abstract
Epi-cochlioquinone A, a novel acyl-CoA : cholesterol acyltransferase inhibitor produced by Stachybotrys bisbyi: T. Fujioka, et al.; J. Antibiot. (Tokyo) 49, 409 (1996) Abstract
Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola: H.J. Jung, et al.; Bioorg. Med. Chem. 11, 4743 (2003) Abstract
Inhibitory activity of diacylglycerol acyltransferase by cochlioquinones A and A1: H.B. Lee, et al.; J. Antibiot. (Tokyo) 56, 967 (2003) Abstract
Cochlioquinones and epi-cochlioquinones: antagonists of the human chemokine receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum: K. Yoganathan, et al.; J. Antibiot. (Tokyo) 57, 59 (2004) Abstract
Further Categories Containing This Product:
CC Chemokines & Receptors / Related Products • Vitamins • NAD+ Metabolism / Related Products
 
 
ALX-350-341 Revised 14-Nov-07
Cochlioquinone B
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Angiogenesis Research
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ALX-350-341-MC05   0.5 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C28H40O6
MW: 472.6
CAS NUMBER: 32450-26-3
SOURCE/HOST: Isolated from Bipolaris leersia MST-FP107.
PURITY: ≥99% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Antagonist of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1). Inhibitor of NADH-ubiquinone reductase. Phytotoxic agent inhibiting root growth.
Product Specific Literature References
Cochlioquinones and epi-cochlioquinones: antagonists of the human chemokine receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum: K. Yoganathan, et al.; J. Antibiot. (Tokyo) 57, 59 (2004) Abstract
Further Categories Containing This Product:
CC Chemokines & Receptors / Related Products • Vitamins • NAD+ Metabolism / Related Products
 
 
ALX-430-033 Revised 19-Jul-07
Colcemid
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SYNONYMS Demecolcine
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cytoskeletal Research
Ordering Information
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ALX-430-033-M001   1 mg 30.00 USD Add To Cart
ALX-430-033-M005   5 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C21H25NO5
MW: 371.4
CAS NUMBER: 477-30-5
MERCK INDEX: 14: 2887
SOURCE/HOST: Semisynthetic from colchicine (Prod. No. ALX-380-033).
PURITY: ≥99%
APPEARANCE: Light yellow powder.
SOLUBILITY: Soluble in 100% ethanol, chloroform or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY:

Stock solutions are stable for at least 6 months when stored at -20°C.
HAZARD: MAY BE MUTAGENIC. MAY BE TERATOGENIC. TOXIC.

Product Description
Depolymerizes microtubules and inhibits their formation. Induces apoptosis.
Product Specific Literature References
Laminin-induced process outgrowth from isolated fetal rat C-cells: I. Nishiyama & T. Fujii; Exp. Cell. Res. 198, 214 (1992) Abstract
Colcemid and the mitotic cycle: C.L. Rieder & R.E. Palazzo; J. Cell. Sci. 102, 387 (1992) Abstract
Cytoskeletal elements regulate the distribution of nerve growth factor receptors in PC12 cells: P.E. Spoerri & F.J. Roisen; J. Neurosci. Res. 31, 494 (1992) Abstract
Effect of colcemid on the water permeability response to vasopressin in isolated perfused rabbit collecting tubules: M.E. Phillips & A. Taylor; J. Physiol. 456, 591 (1992) Abstract
Effects of colcemid concentration on chromosome aberration analysis in human lymphocytes: R. Kanda, et al.; J. Radiat. Res. (Tokyo) 35, 41 (1994) Abstract
Induction of apoptosis by the anti-tubulin drug colcemid: relationship of mitotic checkpoint control to the induction of apoptosis in HeLa S3 cells: S.W. Sherwood, et al.; Exp. Cell. Res. 215, 373 (1994) Abstract
Dissociation of nuclear and cytoplasmic cell cycle progression by drugs employed in cell synchronization: L. Urbani, et al.; Exp. Cell. Res. 219, 159 (1995) Abstract
Colcemid-induced apoptosis of cultured human glioma: electron microscopic and confocal laser microscopic observation of cells sorted in different phases of cell cycle: T. Tsuchida, et al.; Cytometry 31, 295 (1998) Abstract
Protein phosphatase-1 activation and association with the retinoblastoma protein in colcemid-induced apoptosis: F. Puntoni & E. Villa-Moruzzi; BBRC 266, 279 (1999) Abstract
Expression of apoptosis and cell cycle related genes in proliferating and colcemid arrested cells of divergent lineage: B.W. Gallaher, et al.; Cell. Mol. Biol. 46, 79 (2000) Abstract
Spontaneous chromosome loss and colcemid resistance in lymphocytes from patients with myotonic dystrophy type 1: M. Casella, et al.; Cytogenet. Genome Res. 100, 224 (2003) Abstract
Further Categories Containing This Product:
Natural Products - Apoptosis Inducers & Inhibitors • Microtubule Modulators
 
 
ALX-380-033 Revised 17-Oct-07
Colchicine
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cytoskeletal Research
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ALX-380-033-G001   1 g 58.00 USD Add To Cart
Product Specification
FORMULA: C22H25NO6
MW: 399.4
CAS NUMBER: 64-86-8
MERCK INDEX: 14: 2471
RTECS: GH0700000
SOURCE/HOST: Isolated from Colchicum autumnale.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light and moisture.
HAZARD: VERY TOXIC.

Product Description
Inhibitor of microtubules by specific binding to tubulin. Induces apoptosis.