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Unconjugated Lectins
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ALX-650-001 Revised 13-May-08
Bandeiraea simplicifolia Isolectin B4
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SYNONYMS Griffonia Simplicifolia Isolectin B4
PRODUCT LINE Other Products
PRODUCT CATEGORY Unconjugated Lectins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-650-001B-MC05 Biotin 0.5 mg 130.00 USD Add To Cart
ALX-650-001F-MC05 FITC 0.5 mg 130.00 USD Add To Cart
ALX-650-001-M001   1 mg 150.00 USD Add To Cart
Product Specification
SOURCE/HOST: Isolated from Griffonia (Bandeiraea) simplicifolia seeds.
CONCENTRATION: ALX-650-001-FITC: 1mg/ml.
PURITY DETAIL: ALX-650-001: Homogenous by SDS-PAGE.
FORMULATION: ALX-650-001: Lyophilized.
ALX-650-001-Biotin: Lyophilized.
ALX-650-001-FITC: Liquid. In 10mM HEPES, pH 7.5, containing 0.15M sodium chloride, 0.08% sodium azide and 0.1mM Ca2+.
RECONSTITUTION: ALX-650-001: Reconstitute with 10mM HEPES, pH 8.5, containing 0.1mM Ca2+. For preservation at +4°C add 0.08% sodium azide.
ALX-650-001-Biotin: Reconstitute with 1ml of water to a solution in 10mM HEPES, pH 7.5, containing 0.15M sodium chloride, 0.08% sodium azide and 0.1mM Ca2+.
ACTIVITY: Agglutinates blood group B glutaraldehyde-fixed human red blood cells at a concentration of ~3µg/ml. No agglutination of blood group A, glutaraldehyde-fixed human red blood cells occurred at concentrations up to ~100µg/ml.
APPLICATION: A dilution of 5-20µg/ml is recommended for most applications.
QUALITY CONTROL: ALX-650-001F: Free Fluorecein
ALX-650-001F: F/P (molar)
ALX-650-001F: Active Conjugate
ALX-650-001B: Active Conjugate
ALX-650-001B: Lectin Biotinylated
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Prepare fresh dilutions prior to each application.
Product Description
 Binds to α-(1,3) galactosyl galactoside epitopes.
 
 
ALX-350-100 Revised 03-Apr-08
Convulxin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Toxins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-100-C050   50 µg 565.00 USD Add To Cart
Product Specification
MW: ~84kDa.
CAS NUMBER: 37206-04-5
SOURCE/HOST: Isolated from Crotalus durissus terrificus snake venom.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized.
SOLUBILITY: Soluble in organic buffer (HEPES).
ACTIVITY: <50ng/ml (minimal concentration to induce maximum activation of washed human platelets).
APPLICATION: Studies on platelet receptors.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for 8 hours at +20°C, for 2 days at +4°C or for 1 month when stored at -80°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
HAZARD: TOXIC.
Product Description
Heterodimeric C-type lectin. Activates mammalian platelets via binding and clustering of p62/GPVI-receptors under physiological conditions.
Product Specific Literature References
Convulxin, a new toxin from the venom of the South American rattlesnake Crotalus durissus terrificus: J. Prado-Franceschi & O.V. Brazil; Toxicon 19, 875 (1981) Abstract
Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor: J. Polgar, et al.; J. Biol. Chem. 272, 13576 (1997) Abstract
Convulxin-induced platelet adhesion and aggregation: involvement of glycoproteins VI and IaIIa: M. Jandrot-Perrus, et al.; Platelets 9, 207 (1998) Abstract
Collagen, convulxin, and thrombin stimulate aggregation-independent tyrosine phosphorylation of CD31 in platelets. Evidence for the involvement of Src family kinases: M. Cicmil, et al.; J. Biol. Chem. 275, 27339 (2000) Abstract
Convulxin binds to native, human glycoprotein Ib alpha: S. Kanaji, et al.; J. Biol. Chem. 278, 39452 (2003) Abstract
Structure of the snake-venom toxin convulxin: T. Batuwangala, et al.; Acta Crystallogr. D. Biol. Crystallogr. 60, 46 (2004) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Assay performed in aggregometer:
- Incubate 485µl platelets suspension (5x108 platelets/ml) for 1-2 minutes at 37°C until base line is stable.
- Add 5µl 200mM CaCl2.
- Add 5µl 200mM MgCl2.
- Wait until baseline is stable.
- Add 5µl collagen solution (0.5mg/ml) for positive control OR add 5µl convulxin (0.1µg/ml in HEPES).
- Measure aggregation at 37°C.
Further Categories Containing This Product:
Unconjugated Lectins • Platelet Activating Factors [PAF] & Receptors/Related Products
 
 
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