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ALX-385-005 Revised 21-May-08
Kaempferol
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SYNONYMS 3,4',5,7-Tetrahydroxyflavone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonoids/Related Products
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ALX-385-005-M010   10 mg 40.00 USD Add To Cart
ALX-385-005-M050   50 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C15H10O6
MW: 286.2
CAS NUMBER: 520-18-3
MERCK INDEX: 14: 5274
RTECS: LK9275200
PURITY: ≥90%
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in ether or 100% ethanol (hot); slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: IRRITANT. MAY BE MUTAGENIC.

Product Description
Antioxidant flavonoid. Apoptosis inducer. Reversible inhibitor of fatty acid synthase (FAS).
Product Specific Literature References
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Presence of fatty acid synthase inhibitors in the rhizome of Alpinia officinarum hance: B.H. Li & W.X. Tian; J. Enzyme Inhib. Med. Chem. 18, 349 (2003) Abstract
Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?: R. Lupu & J. A. Menendez; Curr. Pharm. Biotechnol. 7, 483 (2006), (Review) Abstract
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables • Fatty Acid Synthase [FAS]/Related Products • Natural Products - Antioxidants • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Chemopreventive Agents
 
 
ALX-350-292 Revised 26-Mar-05
Kahalalide F - Discontinued Due to Patent Restrictions
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-292-C500   500 µg Inquire
Product Specification
FORMULA: C75H124N14O16
MW: 1477.9
CAS NUMBER: 149204-42-2
SOURCE/HOST: Isolated from marine mollusc Elysia rufescens.
PURITY: ≥95%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Highly selective activity against prostate tumors in vitro. Disrupts lysosomal membranes. Inhibitor of c-erbB-2 (ErbB2).
Product Specific Literature References
The antitumoral compound Kahalalide F acts on cell lysosomes: M. Garcia-Rocha, et al.; Cancer Lett. 99, 43 (1996) Abstract
Synthesis and structure determination of kahalalide F (1,2): Synthesis and structure determination of kahalalide F (1,2); J. Am. Chem. Soc. 123, 11398 (2001) Abstract
Chemical and enzymatic stability of a cyclic depsipeptide, the novel, marine-derived, anti-cancer agent kahalalide F: R.W. Sparidans, et al.; Anticancer Drugs 12, 575 (2001) Abstract
Preclinical toxicity studies of kahalalide F, a new anticancer agent: single and multiple dosing regimens in the rat: A.P. Brown, et al.; Cancer Chemother. Pharmacol. 50, 333 (2002) Abstract
Quantitative analysis of the novel depsipeptide anticancer drug Kahalalide F in human plasma by high-performance liquid chromatography under basic conditions coupled to electrospray ionization tandem mass spectrometry: E. Stokvis, et al.; J. Mass. Spectrom. 37, 992 (2002) Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors • Antitumor Agents (Enzyme Inhibitors) • Natural Products - Protein Kinase Inhibitors • erbB-2/Related Products
 
 
ALX-350-223 Revised 07-Apr-08
Kahweol
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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ALX-350-223-M010   10 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C20H26O3
MW: 314.2
CAS NUMBER: 6894-43-5
SOURCE/HOST: Natural product isolated from the unsaponifiable fraction of petroleum ether extract of coffee beans.
PURITY: ≥98% (HPLC)
APPEARANCE: Off-white to yellow solid.
SOLUBILITY: Soluble in ethyl acetate, acetone or DMSO; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Induces glutathione S-transferase. Has anti-cancer, chemoprotective, anti-inflammatory and anti-atherosclerotic properties.
Product Specific Literature References
R.O. Bengis & R.J. Anderson; J. Biol. Chem. 47, 99 (1932)
Isolation and identification of kahweol palmitate and cafestol palmitate as active constituents of green coffee beans that enhance glutathione S-transferase activity in the mouse: L.K. Lam, et al.; Cancer Res. 42, 1193 (1982) Abstract
Effects of derivatives of kahweol and cafestol on the activity of glutathione S-transferase in mice: L.K. Lam, et al.; J. Med. Chem. 30, 1399 (1987) Abstract
Placental glutathione S-transferase (GST-P) induction as a potential mechanism for the anti-carcinogenic effect of the coffee-specific components cafestol and kahweol: B. Schilter, et al.; Carcinogenesis 17, 2377 (1996) Abstract
Chemoprotection against the formation of colon DNA adducts from the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat: W.W. Huber, et al.; Mutat. Res. 376, 115 (1997) Abstract
The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism: C. Cavin, et al.; Carcinogenesis 19, 1369 (1998) Abstract
Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity: C. Cavin, et al.; Food Chem. Toxicol. 40, 1155 (2002) Abstract
The coffee diterpene kahweol inhibits tumor necrosis factor-alpha-induced expression of cell adhesion molecules in human endothelial cells: H.G. Kim, et al.; Toxicol. Appl. Pharmacol. 217, 332 (2006) Abstract
Further Categories Containing This Product:
Glutathione S-Transferase • Antitumor Agents (Enzyme Activators & Inducers) • TNF-alpha & TNF Receptors Other Products • CD11a, CD18 [LFA-1] & CD54 [ICAM-1], CD102 [ICAM-2], CD50 [ICAM-3]/Related Products • Natural Products - Anti-inflammatory Agents • Active Substances from Fruit and Vegetables
 
 
ALX-630-085 Revised 07-Apr-08
Kaliotoxin
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SYNONYMS KTx
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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ALX-630-085-C010   10 µg 190.00 USD Add To Cart
Product Specification
SEQUENCE: H-Gly-Val-Glu-Ile-Asn-Val-Lys-Cys-Ser-Gly-Ser-Pro-Gln-Cys-Leu-Lys-Pro-Cys-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys-Met-Asn-Arg-Lys-Cys-His-Cys-Thr-Pro-Lys-OH
(Disulfide bonds between Cys8-Cys28, Cys14-Cys33 and Cys18-Cys35)
FORMULA: C171H283N55O49S8
MW: 4150.0
CAS NUMBER: 145199-73-1
SOURCE/HOST: Synthetic. Originally isolated from Androctonus mauretanicus mauretanicus scorpion venom.
PURITY: ≥98%
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: POTENT NEUROTOXIN.
Product Description

High conductance Ca2+-activated K+ channel blocker. Highly selective for Kv1.1 and Kv1.3. Blocking of Kv1.3 inhibits T cell activation.
Product Specific Literature References
Kaliotoxin, a novel peptidyl inhibitor of neuronal BK-type Ca(2+)- activated K+ channels characterized from Androctonus mauretanicus mauretanicus venom: M. Crest, et al.; J. Biol. Chem. 267, 1640 (1992) Abstract; Full Text
Synthesis and characterization of kaliotoxin. Is the 26-32 sequence essential for potassium channel recognition?: R. Romi, et al.; J. Biol. Chem. 268, 26302 (1993) Abstract; Full Text
3D structure of kaliotoxin: is residue 34 a key for channel selectivity?: M. Gairi, et al.; J. Pept. Sci. 3, 314 (1997) Abstract
Distribution in rat brain of binding sites of kaliotoxin, a blocker of Kv1.1 and Kv1.3 alpha-subunits: C. Mourre, et al.; J. Pharmacol. Exp. Ther. 291, 943 (1999) Abstract
Selective blocking of voltage-gated K+ channels improves experimental autoimmune encephalomyelitis and inhibits T cell activation: C. Beeton, et al.; J. Immunol. 166, 936 (2001) Abstract
Selective blocking of voltage-gated K+ channels improves experimental autoimmune encephalomyelitis and inhibits T cell activation: C. Beeton, et al.; J. Immunol. 19, 936 (2001), 155 Abstract
Toxin-induced conformational changes in a potassium channel revealed by solid-state NMR: A. Lange, et al.; Nature 440, 959 (2006) Abstract
Further Categories Containing This Product:
K+ Channel Blockers & Inhibitors
 
 
ALX-630-041 Revised 19-May-08
Kaliotoxin (1-37)
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SYNONYMS KTx (1-37)
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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ALX-630-041-C100   100 µg 550.00 USD Add To Cart
Product Specification
SEQUENCE: H-Gly-Val-Glu-Ile-Asn-Val-Lys-Cys-Ser-Gly-Ser-Pro-Gln-Cys-Leu-Lys-Pro-Cys-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys-Met-Asn-Arg-Lys-Cys-His-Cys-Thr-Pro-OH
(Disulfide bonds between Cys8-Cys28, Cys 14-Cys33 and Cys18-Cys35)
FORMULA: C165H271N53O48S8
MW: 4021.8
SOURCE/HOST: Synthetic. Originally isolated from Androctonus mauretanicus mauretanicus.
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
High conductance Ca2+-activated K+ channel blocker.
Product Specific Literature References
Kaliotoxin, a novel peptidyl inhibitor of neuronal BK-type Ca(2+)- activated K+ channels characterized from Androctonus mauretanicus mauretanicus venom: M. Crest, et al.; J. Biol. Chem. 267, 1640 (1992) Abstract; Full Text
Synthesis and characterization of kaliotoxin. Is the 26-32 sequence essential for potassium channel recognition?: R. Romi, et al.; J. Biol. Chem. 268, 26302 (1993) Abstract; Full Text
Kaliotoxin (1-37) shows structural differences with related potassium channel blockers: I. Fernandez, et al.; Biochemistry 33, 14256 (1994) Abstract
3D structure of kaliotoxin: is residue 34 a key for channel selectivity?: M. Gairi, et al.; J. Pept. Sci. 3, 314 (1997) Abstract
On the kaliotoxin and dendrotoxin binding sites on rat brain synaptosomes: N. Tricaud, et al.; Toxicon 38, 1749 (2000) Abstract
Heterogeneous competition of Kv1 channel toxins with kaliotoxin for binding in rat brain: autoradiographic analysis: R. Bessone, et al.; Neurochem. Int. 45, 1039 (2004) Abstract
Toxin-induced conformational changes in a potassium channel revealed by solid-state NMR: A. Lange, et al.; Nature 440, 959 (2006) Abstract
Further Categories Containing This Product:
K+ Channel Blockers & Inhibitors
 
 
ALX-380-049 Revised 07-Feb-08
Kanamycin . sulfate
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-049-G001   1 g 18.00 USD Add To Cart
ALX-380-049-G005   5 g 40.00 USD Add To Cart
Product Specification
FORMULA: C18H36N4O11 . H2SO4
MW: 484.5 . 98.1
CAS NUMBER: 25389-94-0
MERCK INDEX: 14: 5281
SOURCE/HOST: Isolated from Streptomyces kanamyceticus.
PURITY: Contains 5% kanamycin B
SOLUBILITY: Soluble in water.
ACTIVITY: Min. 750µg/mg.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.

Product Description
Aminoglycoside antibiotic with broad antibacterial spectrum, including mycobacteria, many Gram-positive and most Gram-negative bacteria. Inhibits bacterial protein synthesis. Kanamycin resistance is widely used as a selection marker for obtaining transgenic plants.
Product Specific Literature References
Biological studies on kanamycin: T. Takeuchi, et al.; J. Antibiot. (Tokyo) 10, 107 (1957) Abstract
Antimicrobial agents--Part II. The aminoglycosides: streptomycin, kanamycin, gentamicin, tobramycin, amikacin, neomycin: N. S. Brewer; Mayo Clin. Proc. 52, 675 (1977) Abstract
Controversy associated with the common component of most transgenic plants - kanamycin resistance marker gene: S. Jelenic; Food Technol. Biotechnol. 41, 183 (2003), (Review)
Caspase-independent pathways of hair cell death induced by kanamycin in vivo: H. Jiang, et al.; Cell Death Differ. 13, 20 (2006) Abstract
 
 
ALX-380-275 Revised 07-Apr-08
Kanamycin A . sulfate
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-275-G001   1 g 20.00 USD Add To Cart
ALX-380-275-G005   5 g 80.00 USD Add To Cart
Product Specification
FORMULA: C18H36N4O11 . H2SO4
MW: 484.5 . 98.1
CAS NUMBER: 25389-94-0
MERCK INDEX: 14: 5281
RTECS: NZ3225030
SOURCE/HOST: Isolated from Streptomyces kanamyceticus.
APPEARANCE: White to off-white crystalline powder.
SOLUBILITY: Soluble in water (50mg/ml).
ACTIVITY: Potency is >750µg/ml (on dry basis).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description

Aminoglycoside antibiotic. Binds to the 70S ribosomal subunit. Inhibits translocation and elicits miscoding. Interaction with ribosomes may be prevented by aminoglycoside modifying enzymes. Effective against Gram-negative and Gram-positive bacteria and mycoplasma.
Product Specific Literature References
Studies on Streptomyces kanamyceticus, producer of kanamycin: Y. Okami, et al.; J. Antibiot. 12, 252 (1959) Abstract
Infection of the protoplasts of Streptomyces kanamyceticus with deoxyribonucleic acid preparation from actinophage PK-66: M. Okanishi, et al.; J. Bacteriol. 92, 1850 (1966) Abstract; Full Text
The total synthesis of kanamycin A: S. Umezawa, et al.; J. Antibiot. 21, 367 (1968) Abstract
Utilization of carbon and nitrogen sources by Streptomyces kanamyceticus for kanamycin production: K. Basak & S.K. Majumdar; Antimicrob. Agents Chemother. 4, 6 (1973) Abstract; Full Text
Interaction of kanamycin A and kanamycin B with phospholipids: M.W. Yung & C. Green; J. Antibiot. 40, 862 (1987) Abstract
Antibiotic MICs and short time-killing against Helicobacter pylori: therapeutic potential of kanamycin: Y. Irie, et al.; J. Antimicrob. Chemother. 40, 235 (1997) Abstract
 
 
ALX-380-094 Revised 14-Feb-08
Kanamycin B . sulfate
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SYNONYMS Bekanamycin . sulfate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-094-M250   250 mg 50.00 USD Add To Cart
Product Specification
FORMULA: C18H37N5O10 . H2SO4
MW: 483.5 . 98.1
CAS NUMBER: 29701-07-3
MERCK INDEX: 14: 5281
RTECS: WK1976500
SOURCE/HOST: Isolated from Streptomyces kanamyceticus.
PURITY: ≥95% (TLC)
APPEARANCE: White to off-white crystalline powder.
SOLUBILITY: Soluble in water (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Aminoglycoside antibiotic. Binds to the 70S ribosomal subunit. Inhibits translocation and elicits miscoding. Effective against Gram-negative and Gram-positive bacteria and mycoplasma.
Product Specific Literature References
Studies on Streptomyces kanamyceticus, producer of kanamycin: Y. Okami, et al.; J. Antibiot. 12, 252 (1959) Abstract
The Structure of Kanamycin B: T. Ito, et al.; J. Antibiot. 17, 189 (1964) Abstract
The total synthesis of kanamycin B: S. Umezawa, et al.; J. Antibiot. 21, 424 (1968) Abstract
Utilization of carbon and nitrogen sources by Streptomyces kanamyceticus for kanamycin production: K. Basak & S.K. Majumdar; Antimicrob. Agents Chemother. 4, 6 (1973) Abstract; Full Text
Interaction of kanamycin A and kanamycin B with phospholipids: M.W. Yung & C. Green; J. Antibiot. 40, 862 (1987) Abstract
In vitro selection of RNA against kanamycin B: M. Kwon, et al.; Mol. Cells 11, 303 (2001) Abstract
 
 
ALX-380-076 Revised 16-Jun-08
Kasugamycin . hydrochloride
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-076-G001   1 g 52.00 USD Add To Cart
Product Specification
FORMULA: C14H25N3O9 . HCl
MW: 379.4 . 36.5
CAS NUMBER: 6980-18-3
SOURCE/HOST: Isolated from Streptomyces kasugaensis.
PURITY: ≥80%
APPEARANCE: White to tan powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Unique aminoglycoside antibiotic with less potential to create cross-resistant human pathogens compared to other aminoglycoside antibiotics. Effective against Gram-negative bacteria. Used as a pesticide. Binds to the 30S subunit of bacterial ribosome and suppresses protein synthesis. Inhibits translation initiation of canonical but not of leaderless messenger RNAs.
Product Specific Literature References
A new antibiotic, kasugamycin: H. Umezawa, et al.; J. Antibiotics 18, 101 (1965)
Antimicrobial activity of kasugamycin: M. Hamada, et al.; J. Antibiotics 18, 104 (1965)
Pharmacology of kasugamycin and the effect on Pseudomonas infection: T. Takeuchi, et al.; J. Antibiotics 18, 107 (1965)
Comparative studies on in vitro activities of kasugamycin and clinically-used aminoglycoside antibiotics: T. Tamamura & K. Sato; Jpn. J. Antibiot. 52, 57 (1999) Abstract
Protein folding in Escherichia coli: role of 23S ribosomal RNA: S. Chattopadhyay, et al.; Biochim. Biophys. Acta 1429, 293 (1999) Abstract
Differential inhibition of 30S and 70S translation initiation complexes on leaderless mRNA by kasugamycin: I. Moll & U. Blasi; BBRC 297, 1021 (2002) Abstract
The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation: F. Schluenzen, et al.; Nat. Struct. Mol. Biol. 13, 871 (2006) Abstract
Further Categories Containing This Product:
Pesticides/Related Products
 
 
ALX-380-230 Revised 07-Apr-08
Kazusamycin A
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SYNONYMS Kazusamycin
Hydroxyleptomycin B
Antibiotic CL 1957B
Hydroxyelactocin
PD 114,721
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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